Advances in the Metabolic Mechanism and Functional Characteristics of Equol

Foods, Journal Year: 2023, Volume and Issue: 12(12), P. 2334 - 2334

Published: June 10, 2023

Equol is the most potent soy isoflavone metabolite and produced by specific intestinal microorganisms of mammals. It has promising application possibilities for preventing chronic diseases such as cardiovascular disease, breast cancer, prostate cancer due to its high antioxidant activity hormone-like activity. Thus, it great significance systematically study efficient preparation method equol functional This paper elaborates on metabolic mechanism in humans; focuses biological characteristics, synthesis methods, currently isolated equol-producing bacteria; looks forward future development direction, aiming provide guidance promotion field food health products.

Language: Английский

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Enhancing Skin Anti-Aging through Healthy Lifestyle Factors

Cosmetics, Journal Year: 2023, Volume and Issue: 10(5), P. 142 - 142

Published: Oct. 12, 2023

Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.

Language: Английский

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Urinary-related disorders: role of polyphenols

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 113 - 148

Published: Jan. 1, 2025

Language: Английский

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Associations of dietary patterns and lower urinary tract symptoms (LUTS) in Korean adults

Nutrition Research and Practice, Journal Year: 2025, Volume and Issue: 19(2), P. 318 - 318

Published: Jan. 1, 2025

Dietary factors act on lower urinary tract symptoms (LUTS). This study examined the relationship between overall diet quality and LUTS. analyzed data from examinees who visited a general hospital in Korea (October 13, 2014-March 12, 2020). The number of subjects was 6,506 adult men. recommended food score used to evaluate diet, International Prostate Symptom Score quantify Logistic regression analysis derive odds ratio (OR) 95% confidence interval (CI) dietary influence age, education, marital history, income, occupation, smoking, drinking, exercise, metabolic syndrome, body mass index (BMI), prostate-specific antigen (PSA) level determine net group with high showed incidence LUTS than relatively (OR, 0.88; CI, 0.79-0.99). These results were also observed after correcting for other risk associated variables: BMI, PSA level. correlated. Nevertheless, further research will be needed find

Language: Английский

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Exploring the use of phytotherapy in benign prostatic hyperplasia [BPH]: a systematic review

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 412 - 412

Published: April 8, 2025

Background Benign prostatic hyperplasia [BPH] is a prevalent condition among aging men, characterized by prostate gland enlargement leading to lower urinary tract symptoms [LUTS]. Conventional treatments like alpha-blockers and 5-alpha-reductase inhibitors, though effective, often result in adverse effects. This has spurred interest phytotherapy, leveraging plant-derived compounds mitigate BPH due their safety, cost-effectiveness, patient preference. Method The review highlighted 84 studies involving diverse plants bioactive compounds. Prominent examples include Serenoa repens [saw palmetto], Urtica dioica [nettle root], Cucurbita pepo [pumpkin seed], Pygeum africanum [African cherry]. These exhibit mechanisms such as 5α-reductase inhibition, anti-inflammatory effects, modulation of oxidative stress. Clinical preclinical findings demonstrate improved flow, reduced volume, alleviated LUTS. However, variability methodologies, extract preparations, dosages poses challenges standardization. Results Serenoa repens Cucurbita pepo Pygeum africanum Conclusion Phytotherapy holds significant potential management, offering symptom relief with minimal side While promising, further robust clinical trials are essential validate efficacy, establish standardized protocols, ensure integration into mainstream therapeutic frameworks.

Language: Английский

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Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future

Journal of Clinical and Translational Hepatology, Journal Year: 2024, Volume and Issue: 12(4), P. 389 - 405

Published: Feb. 28, 2024

Hepatocellular carcinoma (HCC) is a common cancer, and the body's immune responses greatly affect its progression prognosis of patients. Immunological suppression maintenance self-tolerance in tumor microenvironment are essential responses, these form part theoretical foundations immunotherapy. In this review, we first discuss HCC, describe immunosuppression review major biomarkers used to track HCC response treatment. We then examine antibody-based therapies, with focus on checkpoint inhibitors (ICIs), monoclonal antibodies that target key proteins (programmed cell death protein 1, anti-cytotoxic T-lymphocyte associated 4, programmed death-ligand 1) which have transformed treatment other cancers. ICIs may be alone or conjunction various targeted therapies for patients advanced who receiving first-line treatments subsequent treatments. also use different cellular immunotherapies, including T receptor (TCR) therapy chimeric antigen (CAR) therapy. vaccines, adjuvant immunotherapy, oncolytic virotherapy, goals future research development HCC.

Language: Английский

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Plant-based diets and urological health

Nature Reviews Urology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

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Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats

Journal of Toxicology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 12

Published: March 7, 2024

Croton membranaceus Mull. Arg. is a traditional medicinal plant frequently employed in Ghana for the treatment of benign prostatic hyperplasia and prostate cancer. The objective this study was to determine acute oral toxicity aqueous stem extract (CMASE) male Sprague–Dawley (S-D) rats. CMASE evaluated using S-D rats randomly divided into four groups five animals each. Three (low dose, median high dose) received single doses (1000, 2500, 5000 mg/kg body weight, respectively) an gavage. control group given distilled water. After 14 days daily observations, hematological, biochemical, histopathological analyses were conducted on From results obtained, up did not cause death or induce any clinical indications during period. Also, mean weight hematological indices assessed significantly affected by various compared group. However, serum uric acid creatinine levels decreased ( $p<0.001$ ) after administration. Serum liver function enzyme levels, including alkaline phosphatase (ALP), alanine aminotransferases (ALT), aspartate (AST), proteins (total albumin) exhibited significant id="M2">p<0.001 non dose-dependent changes (increases decreases) treated controls. Other biochemical indices, however, differ between gross pathological histological analysis heart, liver, kidney tissues reveal histoarchitecture. LD50 greater than mg/kg, indicating that relatively safe. It must, be used with care as substitute roots.

Language: Английский

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Non-Surgical Bleeding and Transurethral Resection of the Prostate (TURP) Syndrome after TURP Surgery: A Case Report and Literature Review

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 367 - 375

Published: July 12, 2024

Patients undergoing transurethral resection of the prostate (TURP) surgery can develop TURP syndrome and post-TURP bleeding. Post-TURP bleeding be surgical, from arteries or venous sinuses, non-surgical, due to coagulopathy preventing clot formation. Non-surgical may high concentrations urokinase tissue plasminogen activator (tPA) in urine that cause fibrinolytic changes increase risk. Urine tPA have both local systemic effects prevent blood formation locally at site surgery, systemically through leaking into stream. Another complication happen is syndrome, absorption hypotonic glycine fluid prostatic plexus. present with hyponatremia, bradycardia, hypotension, which preceded by hypertension. In this case report, we had a patient benign hyperplasia (BPH) who developed non-surgical These complications were transient for one day after surgery. The effect explains inducing Coagulation studies showed explained leakage conclusion, presence agents urine, including tPA. There deficiency existing explaining pathophysiology risk TURP. Herein, discuss possible developing More research effort should directed explore area investigate appropriate medications treat We suggest monitoring patients’ coagulation profiles electrolytes because severe acute changes, our review literature, current clinical trials testing use an antifibrinolytic agent, Tranexamic acid, irrigation antagonizing activity

Language: Английский

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The Etiology and Pathogenesis of Benign Prostatic Hyperplasia: The Roles of Sex Hormones and Anatomy

Research and Reports in Urology, Journal Year: 2024, Volume and Issue: Volume 16, P. 205 - 214

Published: Sept. 1, 2024

Benign prostatic hyperplasia (BPH) mainly causes lower urinary tract symptoms in ageing men, but its exact etiology and pathogenesis have not been established. The objective of this review was to design an update on the advances human BPH research. We undertook a literature search for identifying studies roles sex hormones (androgens estrogens) onset development using Pubmed database. In literature, many indicated that obesity are factors preceding BPH. No evidence role testosterone (T) or dihydrotestosterone (DHT) is found initiation. Since exclusively occurs transitional zone (TZ) surrounding urethra, it postulated years exposure uncharacterized toxins could disrupt homeostasis stroma and/or epithelium typically occurring men. After cellular damage subsequent inflammation generated, intraprostatic DHT produced from T by 5α-reductase promotes development. Further, estrogens take part nodular proliferation stromal cells some patients. confounding may attenuate prostate tumor TZ. conclusion, suggests androgens etiological BPH, along with chronic responsible epithelial as prediction PCa progression still need further investigation.

Language: Английский

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