Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion DOI Creative Commons
Valeria Lucarini, Daniela Nardozi, Valentina Angiolini

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1761 - 1761

Published: June 19, 2023

Gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Metastasis is leading cause death from GI cancer; thus, studying processes that regulate cancer cell migration paramount importance development new therapeutic strategies. In this review, we summarize mechanisms adopted by cells to promote and subsequent metastasis formation highlighting key role tumor microenvironment components play in deregulating cellular pathways involved these processes. We, therefore, provide an overview different microRNAs promoting their as potential biomarkers prognosis, monitoring, diagnosis patients. Finally, relate possible use nutraceuticals a strategy targeting numerous invasiveness.

Language: Английский

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies DOI Creative Commons

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Rahul Maheshwari

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(4), P. 967 - 990

Published: March 19, 2024

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.

Language: Английский

Citations

17
Non-coding RNAs as mediators of epithelial - Mesenchymal transition (EMT) in metastatic colorectal cancers DOI

Aisha Shigna Nadukkandy,

Britny Blaize,

C. Selvaa Kumar

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111605 - 111605

Published: Jan. 20, 2025

Language: Английский

Citations

1
Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence DOI

K Sandhanam,

Tamilanban Thamaraikani,

K. Manasa

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 553, P. 1 - 18

Published: June 27, 2024

Language: Английский

Citations

5
Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective DOI Creative Commons

Vaishak Kaviyarasan,

Alakesh Das,

Dikshita Deka

et al.

International Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 28, 2024

Abstract Purpose Colorectal cancer (CRC) remains one of the leading causes cancer-related mortality worldwide. Metastatic colorectal (mCRC) continues to present significant challenges, particularly in patients with proficient mismatch repair/microsatellite stable (pMMR/MSS) tumors. This narrative review aims provide recent developments immunotherapy for CRC treatment, focusing on its efficacy and challenges. Methods discussed various immunotherapeutic strategies including immune checkpoint inhibitors (ICIs) targeting PD-1 PD-L1, combination therapies involving ICIs other modalities, chimeric antigen receptor T-cell (CAR-T) cell therapy, vaccines. The role tumor microenvironment evasion mechanisms was also explored understand their impact effectiveness these therapies. Results provides a comprehensive update advancements CRC, highlighting potential approaches, inhibitors, therapies, CAR-T vaccination strategies. results MSI-H/dMMR tumors, which have improvements survival rates been observed. Furthermore, this addresses challenges faced treating pMMR/MSS resistant immunotherapy. Conclusion Immunotherapy plays treatment However, many remain, especially CRC. need further research into biomarker development, deeper understanding treatment.

Language: Английский

Citations

4
Exploring anticancer properties of new triazole-linked benzenesulfonamide derivatives against colorectal carcinoma: Synthesis, cytotoxicity, and in silico insights DOI
Belma Zengin Kurt, Özge Özmen, Dilek Öztürk Civelek

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 119, P. 118060 - 118060

Published: Jan. 5, 2025

Language: Английский

Citations

0
Tumor-educated Neutrophils Induce Epithelial-mesenchymal Transition and Metastasis in Colorectal Cancer Through Interleukin-17a Secretion DOI

Yibing Gong,

Qingshuang Luo,

Haiqi Tan

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 190, P. 156928 - 156928

Published: March 31, 2025

Language: Английский

Citations

0
Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation DOI

Maryam Kananivand,

Fatemeh Nouri,

Mohammad Hasan Yousefi

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

Language: Английский

Citations

0
Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients DOI Creative Commons
Peter Kubatka, Bianka Bojková, Natália Nosálová

et al.

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer drug resistance poses a significant challenge in oncology, primarily driven by cancer cell plasticity, which promotes tumor initiation, progression, metastasis, and therapeutic evasion many different cancers. Breast cancers (BCs) are prominent example of that, with an estimated 2.3 million new cases 670,000 BC-related deaths registered worldwide annually. Triple-negative BC is especially challenging for treatments demonstrating particularly aggressive disease course, early manifestation metastatic disease, frequent drug-resistant types, poor individual outcomes. Although chemosensitizing agents have been developed, their clinical utility oncology remains unproven. The mitogen-activated protein kinase (MAPK) pathway considered critical regulator intracellular extracellular signaling highly relevant both — genetic epigenetic modifications. Dysregulation the MAPK pathways plays role conferring chemoresistance BC. Contextually, targeting represents promising strategy overcoming enhancing efficacy anticancer treatment. On other hand, flavonoids, class phytochemicals, key modulators signaling. Flavonoids interact ERK, JNK, p38, ERK5 cascade present avenue developing novel anti-cancer therapies re-sensitizing treatment Compounds such as quercetin, kaempferol, genistein, luteolin, myricetin, EGCG, baicalein, baicalin, nobiletin, morin, delphinidin, acacetin, isorhamnetin, apigenin, silymarin, among others, identified specific signaling, exerting complex downstream effects cells increasing therewith suppressing growth aggressivity. These properties reflect mechanisms great relevance to overcome overall management. This article highlights corresponding provides clinically illustrations framework 3P medicine primary (protection individuals at high risk against health-to-disease transition) secondary care progression). 3PM novelty makes good use patient phenotyping stratification, predictive multi-level diagnostics, application Artificial Intelligence (AI) tools individualized interpretation big data all proposed cost-effective tailored profiles clear benefits patients advanced

Language: Английский

Citations

0
Integration of Machine Learning Algorithms and Single‐Cell Sequencing Analysis Reveals the Efferocytosis‐Related Molecular Subtype and Prognostic Scoring Index in Colon Adenocarcinoma DOI

Kun Ju,

Xiaolei Liu, Qian Wang

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Background Colon adenocarcinoma (COAD) is a leading cause of cancer‐related mortality, with limited therapies for advanced stages. Efferocytosis, the clearance apoptotic cells, modulates tumor immunity and progression. We investigated efferocytosis‐related genes (ERRGs) in COAD through multiomics integration. Methods analyzed data from public databases to identify differentially expressed ERRGs their molecular subtypes. An ERRG score index was developed using integrated machine learning algorithms evaluate its predictive capacity. Single‐cell sequencing vitro functional assays were performed validate key findings. Results Among 162 ERRGs, 22 dysregulated COAD. Three subtypes exhibited distinct prognoses, immune profiles, therapy responses. The system accurately predicted clinical outcomes, low scores correlating improved survival sensitivity certain drugs. analysis highlighted TIMP1 as regulator, confirmed by knockdown suppressing proliferation migration vitro. Conclusion demonstrate prognostic therapeutic relevance COAD, providing insights into subtyping immunotherapy prediction. emerges potential target, warranting further validation.

Language: Английский

Citations

0
Histone modifications and their roles in macrophage-mediated inflammation: a new target for diabetic wound healing DOI Creative Commons
Jing Wang, Jiawei Feng, Yiming Ni

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 20, 2024

Impaired wound healing is one of the main clinical complications type 2 diabetes (T2D) and a major cause lower limb amputation. Diabetic wounds exhibit sustained inflammatory state, reducing inflammation crucial to diabetic management. Macrophages are key regulators in healing, their dysfunction would exacerbated poor wounds. Gene regulation caused by histone modifications can affect macrophage phenotype function during healing. Recent studies have revealed that targeting histone-modifying enzymes local, macrophage-specific manner reduce responses improve This article will review significance as well illustrate how polarization Targeting with may provide novel therapeutic strategies for treatment

Language: Английский

Citations

3