Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 218, P. 111915 - 111915

Published: Feb. 13, 2024

Language: Английский

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The Role of TNF-α in Neuropathic Pain: An Immunotherapeutic Perspective

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 785 - 785

Published: May 14, 2025

TNF-α is a pro-inflammatory cytokine that plays pivotal role in the regulation of immune responses. It predominantly produced by activated macrophages, although other cell types, such as T lymphocytes and NK cells, also contribute to its secretion. participates various physiological processes, including proliferation differentiation. Moreover, has been implicated pathogenesis numerous inflammatory autoimmune disorders. Recent studies have highlighted important neuropathic pain, complex frequently disabling condition caused nerve injury or dysfunction. Increased levels nervous system associated with onset contributing neuronal sensitization alterations pain signaling pathways. This study supports idea connects system, thereby supporting our understanding neuroimmune interface bringing potential treatment against pain: targeting TNF-α. Anti-TNF-α antibody administration reduces behaviors neuroinflammation preclinical animal models. Simultaneously, clinical trials are evaluating safety efficacy anti-TNF-α treatments, preliminary results indicating promising outcomes patients experiencing pain. Here, goes beyond conventional spectrum pathologies initiates new mechanism-based approach defining improving quality life individuals affected together an area colossal unmet need.

Language: Английский

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The effects of COVID-19 infection on working memory: a systematic review

Current Medical Research and Opinion, Journal Year: 2023, Volume and Issue: 40(2), P. 217 - 227

Published: Nov. 27, 2023

Background Studies demonstrate that people who have been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, experienced cognitive dysfunction, including working memory impairment, executive and decreased concentration. This review aimed to explore incidence impairment possible concomitant symptoms in phase (< 3 months) chronic (> 6 COVID-19.

Language: Английский

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Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson’s disease

Journal of Anesthesia Analgesia and Critical Care, Journal Year: 2024, Volume and Issue: 4(1)

Published: May 14, 2024

Abstract Pain is a complex phenomenon, and basal ganglia circuitry integrates many aspects of pain including motor, emotional, autonomic, cognitive responses. Perturbations in dopamine (DA) signaling are implicated the pathogenesis chronic due to its involvement both perception relief. Several lines evidence support role endocannabinoids (eCBs) regulation electrical chemical DAergic neuron function excitability, synaptic transmission, integration, plasticity. However, eCBs play an even more intricate intimate relationship with DA, as indicated by adaptive changes eCB system following DA depletion. Although precise mechanisms underlying control on not fully understood, given high correlation system, it conceivable that may be part these mechanisms. In this brief survey, we describe reciprocal eCB-DA neurotransmission particular emphasis actions ionic neurons mediated CB receptors or independent them. Furthermore, analyze imbalance which characterizes condition report implications reduced levels for Parkinson’s disease. Lastly, discuss potential development future therapeutic strategies treatment pain.

Language: Английский

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Long Neuro-COVID-19: Current Mechanistic Views and Therapeutic Perspectives

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1081 - 1081

Published: Aug. 28, 2024

Long-lasting COVID-19 (long COVID) diseases constitute a real life-changing burden for many patients around the globe and, overall, can be considered societal and economic issues. They include variety of symptoms, such as fatigue, loss smell (anosmia), neurological–cognitive sequelae, memory loss, anxiety, brain fog, acute encephalitis, stroke, collectively called long neuro-COVID-19 neuro-COVID). also cardiopulmonary myocardial infarction, pulmonary damage, fibrosis, gastrointestinal dysregulation, renal failure, vascular endothelial onset new diabetes, with each symptom usually being treated individually. The main unmet challenge is to understand mechanisms pathophysiologic in particular neurological symptoms. This mini-review presents mechanistic hypotheses explain multiple neuro-COVID namely immune dysregulation prolonged inflammation, persistent viral reservoirs, dysfunction, disruption neurotransmitter signaling along various paths. We suggest that nucleoprotein N SARS-CoV-2 constitutes “hub” between virus host immunity, neurotransmission.

Language: Английский

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Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 397 - 405

Published: Sept. 1, 2024

Language: Английский

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Neurological, psychological, psychosocial complications of long-COVID and their management

Neurological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Since it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health economies of millions individuals all over globe. At level individual too, many patients are not recovering fully experiencing long-term condition now commonly termed 'long-COVID'. Long-COVID is collection symptoms which must last more than 12 weeks following initial COVID infection, cannot be adequately explained by alternate diagnoses. The neurological psychosocial long-COVID itself global crisis therefore preventing, diagnosing, managing these paramount importance. This review focuses primarily on: functioning deficits; mental impacts; mood problems; associated issues, among suffering from with an eye towards basis symptoms. A concise account clinical relevance impacts long-COVID, effects morbidity, varied approaches in chronic conditions was extracted literature, analysed reported. comprehensive plausible pathophysiological mechanisms involved development its management, future research needs have been discussed.

Language: Английский

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Characterizing Secondary and Atypical Parkinsonisms: Defining Features and Clinical Variability

Neuroglia, Journal Year: 2024, Volume and Issue: 5(4), P. 467 - 487

Published: Nov. 28, 2024

Parkinsonism is a clinical syndrome characterized by akinesia/bradykinesia, muscle rigidity, resting tremor, and postural instability. Within the group of parkinsonisms Parkinson’s disease, also known as neurodegenerative parkinsonian syndrome. The atypical was established due to existence sporadic that do not share exact etiology disease. Additionally, arise from causes other than neurodegeneration have been classified secondary parkinsonisms. With this in mind, given diversity etiologies can trigger parkinsonism, it crucial understand symptomatology its relationship with basal ganglia (including damage nigrostriatal pathway, neuroinflammation, neuronal damage). Only then will be possible propose appropriate treatments for each variant parkinsonism.

Language: Английский

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Headache and Dizziness as Prevailing Clinical Manifestations in Parkinson's Patients Following COVID-19

Archives of Neuroscience, Journal Year: 2024, Volume and Issue: 11(3)

Published: June 12, 2024

Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has posed significant global health challenges, particularly for vulnerable populations. Objectives: This retrospective report from the Iranian Network Research in Viral Diseases (INRVD) investigates common clinical symptoms of COVID-19 individuals with Parkinson's (PD). suggests neurological complications can occur during SARS-CoV-2 infection, but there are limited studies on PD patients COVID-19. Given probable heightened vulnerability patients, evaluating symptoms, especially manifestations, is crucial. Methods: Data 54 were collected INRVD March 2020 to May 2021. Nasal, oropharyngeal, and nasopharyngeal swabs presenting following CDC guidelines. Following sample collection, RT-PCR assays performed confirmation. Statistical analysis was conducted using Chi-square test Fisher's exact test. Results: Among included study, 27 tested positive Of subjects analyzed, 38.9% female 61.1% male. Comparison revealed a higher rate sore throat (74%) shortness breath (81%) group as disease. Interestingly, rates dizziness (67%) headache observed Conclusions: study enhances our understanding diverse manifestations its impact underlying conditions such PD. increased prevalence among underscores need further investigation clarify whether these directly result infection or if they may also be influenced itself treatment. It important consider that while attributed disorder linked medication medical interventions, typically associated

Language: Английский

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ДЕЯКІ АСПЕКТИ ПАТОГЕНЕЗУ СИНДРОМУ ДЕФІЦИТУ УВАГИ І ГІПЕРРЕАКТИВНОСТІ У ЖІНОК (огляд літератури)

Перспективи та інновації науки, Journal Year: 2024, Volume and Issue: 8(42)

Published: Sept. 2, 2024

ДЕЯКІ АСПЕКТИ ПАТОГЕНЕЗУ СИНДРОМУ ДЕФІЦИТУ УВАГИ І ГІПЕРРЕАКТИВНОСТІ У ЖІНОК (огляд літератури)Анотація.Синдром дефіциту уваги і гіперактивності (СДУГ)є мультифакторіальним розладом психіки у дітей дорослих, основними проявами якого є гіперактивність, неуважність та бурхлива реакція на мінімальні подразники.Цей синдром пов'язують із дисфункцією дофамінергічної системи.Було виявлено зв'язок між синдромом полікістозних яєчників (СПЯ) жінок виникненням них СДУГ.Одна з головних причин СПЯ зміна рівні гормонівгіперандрогенемія, яка призводить до інсулінорезистентності

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