Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(3), P. 507 - 535

Published: Sept. 6, 2023

Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing an emerging field of research that investigates influence eating patterns on our circadian rhythm, metabolism, overall health. This narrative review examines relationship meal timing, clock genes, hormones, It analyzes existing literature experimental data to explore connection mealtime, rhythms, processes. The available evidence highlights importance aligning mealtime with body’s natural rhythms promote health prevent disorders. Specifically, studies show consuming meals later in day associated elevated prevalence disorders, while early time-restricted eating, such as having breakfast earlier dinner, improves levels glucose blood substrate oxidation. Circadian including cortisol melatonin, interact mealtimes play vital roles regulating Cortisol, aligned dawn diurnal mammals, activates energy reserves, stimulates appetite, influences gene expression, synchronizes clocks. Consuming during periods melatonin levels, specifically night, has been correlated potential implications tolerance. Understanding mechanisms synchronization, genetics, interactions chronotype, sleep duration, hormonal changes, provides valuable insights optimizing dietary strategies timing. knowledge contributes improved well-being by rhythm.

Language: Английский

---

Circadian rhythm disruption promotes M1 macrophages polarization exacerbating the inflammatory response in rosacea

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 1, 2025

Language: Английский

---

Time-of-day dependent promotion of keratinocyte differentiation by Cinnamomum cassia bark extract through the p38 MAPK Pathway

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318360 - e0318360

Published: March 18, 2025

The skin serves as an essential barrier against pathogens and external insults, preventing moisture loss. Chronic conditions such atopic dermatitis stem from impairments in function. Circadian rhythms affect blood flow characteristics, which are significant for understanding dermatitis. Cinnamomum cassia bark, commonly known cinnamon, is extensively utilized both modern Traditional Chinese Medicine its therapeutic properties managing chronic diseases. This study aimed to investigate the potential use of bark enhancing We examined impact extract (CCBE) on circadian clock-mediated enhancement barrier. CCBE enhanced expression keratinocyte differentiation markers, including keratin 10, filaggrin, caspase 14, calpain-1. also increased production hyaluronic acid protein. Additionally, improved rhythm period regulator 2 ( PER2 ). Notably, upregulated markers specifically during morning hours. Furthermore, we discovered that siRNA-mediated knockdown diminished increase induced by CCBE. These findings demonstrate can regulate keratinocytes a time-of-day-dependent manner via clock. augmented phosphorylation p38 JNK, while CCBE-induced FLG was reduced MAPK inhibitors. results suggest strengthen diurnally pathway, representing novel more effective method function accommodates daily variations properties.

Language: Английский

---

The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 232 - 232

Published: Jan. 25, 2024

The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light the importance of PER2 clock gene as a vital antitumor gene. Furthermore, delta-opioid receptors (DOPrs) have been identified playing crucial role differentiation, proliferation migration, which are not only essential for wound healing but also contribute cancer development. In this study, we propose significant association between cutaneous opioid receptor (OPr) activity rhythmicity. To investigate link, conducted 48 h rhythm experiment, during RNA samples were collected every 5 h. We discovered that activation DOPr by its endogenous agonist Met-Enkephalin N/TERT-1 keratinocytes, synchronized dexamethasone, resulted statistically 5.6 delay expression core PER2. Confocal microscopy further confirmed simultaneous nuclear localization DOPr-β-arrestin-1 complex. Additionally, enhanced induced phase shift rhythmic binding β-arrestin-1 promoter. observed regulates transcription target genes, including PER2, facilitating histone-4 acetylation. Through ChIP assay, determined enhances acetylated H4 summary, our findings suggest leads via β-arrestin-1-facilitated chromatin remodeling. Consequently, these results indicate DOPr, much like healing, may play part development influencing

Language: Английский

---

Differential Photosensitivity of Fibroblasts Obtained from Normal Skin and Hypertrophic Scar Tissues

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2126 - 2126

Published: Feb. 9, 2024

It is unclear whether normal human skin tissue or abnormal scarring are photoreceptive. Therefore, this study investigated photosensitivity in and hypertrophic scars. The expression of opsins, which photoreceptor proteins, dermal fibroblasts (NDFs) scar (HSFs) was examined. After exposure to blue light (BL), changes the levels αSMA clock-related genes, specifically PER2 BMAL1, were examined both fibroblast types. Opsins expressed types, with OPN3 exhibiting highest levels. peripheral circadian rhythm disruption, BL induced formation NDFs. In contrast, although HSFs showed gene levels, no distinct observed. level significantly higher decreased same as that NDFs upon exposure. When knocked-down exposed BL, reduction inhibited. This directly triggers synchronization but not HSFs. OPN3-mediated inhibited Although current results did elucidate relationship between rhythms scars, they show can be applied for prevention treatment scars keloids.

Language: Английский

---

Fluctuations in equine cutaneous pH and transepidermal water loss with time of day and ambient conditions

Journal of Equine Veterinary Science, Journal Year: 2024, Volume and Issue: 140, P. 105140 - 105140

Published: June 29, 2024

Language: Английский

---

Regulation of dermal circadian pathways by a novel topical formulation

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 47(1), P. 123 - 133

Published: Sept. 1, 2024

Skin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook Aging Skin, 2016), UV (Biomed Pathol, 2013, 3, 161) blue light (Int J Cosmet 2019, 41, 558). Disruption the skin's endogenous balance, even consistently late bedtime, has deleterious effects on multiple measurements skin health, hydration, barrier protection, microbiome counts regeneration, among others (Clin Investig Dermatol, 2022, 15, 1051). repair processes occur at night help to maintain important aspects (FEBS Lett, 2021, 595, 2413). Interest increasing in development topical products restore proper function. This study demonstrates proprietary formulation regulates new established gene protein biomarkers entrainment demonstrating product's potential appropriate dermal diurnal balance.

Language: Английский

---

Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism

Published: June 28, 2023

Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing an emerging field of research that investigates influence eating patterns on our circadian rhythm, metabolism, overall health. This narrative review examines relationship meal timing, clock genes, hormones, It analyzes existing literature experimental data to explore connection mealtime, rhythms, processes. The available evidence highlights importance aligning mealtime with body’s natural rhythms promote health prevent disorders. Specifically, studies show consuming meals later in day associated a elevated prevalence disorders, while early time-restricted eating, such as having breakfast earlier dinner, improves levels glucose blood substrate oxidation. Circadian including cortisol melatonin, interact mealtimes play vital roles regulating Cortisol, aligned dawn diurnal mammals, activates energy reserves, stimulates appetite, influences gene expression, synchronizes clocks. Consuming during periods melatonin levels, specifically night, has been correlated potential implications tolerance. Understanding mechanisms synchronization, genetics, interactions chronotype, sleep duration, hormonal changes, provides valuable insights optimizing dietary strategies timing. knowledge contributes improved well-being by rhythm.

Language: Английский

---

The Circadian Rhythm of Itching among 241 Adults with Atopic Dermatitis: A Cross-sectional Study

Acta Dermato Venereologica, Journal Year: 2024, Volume and Issue: 104, P. adv35427 - adv35427

Published: Aug. 5, 2024

The pattern of itching in patients with atopic dermatitis has not been systematically studied. Therefore, this study aimed to assess the adults using questionnaires for a circadian rhythm participating at single institution (n = 241). A self-report questionnaire was used and intensity patients. In addition, patients' disease severity (Eczema Area Severity Index [EASI]) quality life (Dermatology Life Quality [DLQI]) were assessed. Itching occurred most frequently (74.69%) greatest (62.66%) between 20:00 00:00, least number (25.31%) experienced 04:00 08:00. DLQI EASI scores both correlated average maximum itch (r 0.582, r 0.533, respectively; 0.539, 0.517, p < 0.001). associated (B 0.179, B 0.204, 95% CI: 0.112 0.246, 0.096 0.313, 0.001), score males family history 0.285, 0.287, 0.094 0.476, 0.478, 0.003). Adult exhibited itching; these results could positively impact treatment approaches.

Language: Английский

---

Cronobiología y aplicaciones médicas (I). Los ritmos circadianos

Medicine - Programa de Formación Médica Continuada Acreditado, Journal Year: 2024, Volume and Issue: 14(23), P. 1350 - 1363

Published: Dec. 1, 2024

---