Proteomics and phosphoproteomics differences between human and cow milk fat globule membrane: An innovative guide for infant formula

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142890 - 142890

Published: Jan. 13, 2025

Language: Английский

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MicroRNA as a new bioactive component in breast milk

Non-coding RNA Research, Journal Year: 2023, Volume and Issue: 8(4), P. 520 - 526

Published: July 11, 2023

Breast milk is a complex and multifaceted fluid that plays critical role in the development of infants. It composed water, carbohydrates, fats, proteins, vitamins, minerals, as well numerous bioactive compounds such hormones, oligosaccharides, immune proteins. Additionally, breast contains microRNAs, which have been found to regulate gene expression impact various aspects infant development. This text provides an overview components human their importance development, with focus on microRNAs. MicroRNAs are short RNA sequences posttranscriptionally, they play important shaping mechanisms immunity, protecting against oxidative stress, promoting thermogenesis. The composition can vary same mother between different feedings, it changes response factors infant's age, feeding frequency duration, time day, maternal health status. Despite variations composition, still complete nutrition for infant. unique microRNA profiles how affected by significant implications disease prevention treatment. Further research needed better understand functions individual molecules potential therapeutic applications.

Language: Английский

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Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 160 - 160

Published: Jan. 3, 2024

In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into circulatory system and organs recipients, especially humans, potentially contribute to modulating health diseases. Evidence suggests that food uptake, by carrying exogenous (xenomiRNAs), regulates individual miRNA profile, modifying redox homeostasis inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, cancer. The capacity diet control levels comprehension unique characteristics dietary in terms gene expression regulation show important perspectives a strategy disease susceptibility via modifications refine clinical outcomes. However, absorption, stability, availability, roles are intriguing currently subject intense debate; additionally, there is restricted knowledge their physiological potential side effects. Within this framework, we provided up-to-date comprehensive on miRNAs’ potential, discussing latest advances controversial issues related role human modulators chronic syndromes.

Language: Английский

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Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)

Published: May 27, 2024

Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability being easily engineered modified, currently exploited promising platform for targeted therapy. In this review, we first summarize current knowledge roles risk etiology, initiation progression cancer, underlying molecular mechanisms. aptamer-modified exosome therapy is then briefly introduced. We also discuss future directions emerging biology perspective

Language: Английский

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Milk Extracellular Vesicles: Natural Nanoparticles for Enhancing Oral Drug Delivery against Bacterial Infections

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(4), P. 1988 - 2000

Published: March 26, 2024

Oral drug delivery is typically preferred as a therapeutic intervention due to the complexities and expenses associated with intravenous administration. However, some drugs are poorly absorbed orally, requiring administration bypass gastrointestinal tract deliver directly into bloodstream. Thus, there an urgent need develop novel platforms overcome challenges of oral low solubility, permeability, degradation, bioavailability. Advances in extracellular vesicles (EVs) natural carriers have provided emerging approaches improve potential applications. Milk not only contains traditional nutrients but also rich EVs. In this Review, we focus mainly on purification milk EVs (mEVs), their safety, advantages mEV-based combatting intestinal infections. Additionally, summarize several mEVs over conventional synthetic carriers, such immunogenicity, high biocompatibility, ability transfer bioactive molecules between cells. Considering unmet gaps clinical translation, it essential review cargo loading future perspectives for use delivery. This overview sheds light alternative treat infections pathogens development systems.

Language: Английский

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Sequencing analysis of bovine milk exosomal miRNA and the effect of Bta-miR-141 on the biological function of HepG2 cells

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105993 - 105993

Published: Jan. 1, 2025

Language: Английский

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Key roles of milk-derived extracellular vesicles in intestinal tract, with special emphasis on microRNAs in extracellular vesicles

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: March 6, 2025

Studies have indicated that milk extracellular vesicles (EVs) are resistant to both the enzymatic activity of digestive enzymes and acidic conditions common in gastrointestinal tract. Thus, intestinal tract efficiently absorbs uses these EVs. There is mounting evidence recent years microRNAs (miRNAs) found EVs derived from essential for prebiotic effect through target gene regulation. In this paper, we summarized sources, biosynthetic processes, cargos, factors affecting milk-derived Furthermore, with particular attention potential communication mechanism cell receptors, including recognizing binding surface receptor cells, internalization uptake, cargos acting on cells. Especially, also explored role several aspects health, such as immunological homeostasis, barrier, injury, inflammatory bowel disease, necrotizing enterocolitis, malignancy, harm other organs connected intestine. We expected use or miRNAs new dietary additives functional regulatory factors. future, will gain more knowledge about substantial impact human intestines health-related matters.

Language: Английский

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MiR-148a-3p Promotes Colorectal Cancer Cell Ferroptosis by Targeting SLC7A11

Cancers, Journal Year: 2023, Volume and Issue: 15(17), P. 4342 - 4342

Published: Aug. 30, 2023

Ferroptosis, an iron-dependent form of cell death, and dysregulated microRNA (miRNA) expression correlate with colorectal cancer (CRC) development progression. The tumor suppressor ability miR-148a-3p has been reported for several cancers. Nevertheless, the role in CRC remains largely undetermined. Here, we aim at investigating molecular mechanisms regulatory targets death mechanism(s). To this end, was evaluated SW480 SW620 cells normal colon epithelial CCD 841 CoN quantitative real-time polymerase chain reaction (qRT-PCR). Data a reduction compared to non-tumor (p < 0.05). Overexpression miR-148a selectively inhibited viability 0.001), while weakly affecting survival At cellular level, mimics promoted apoptotic via caspase-3 activation accumulation mitochondrial reactive oxygen species (ROS) membrane depolarization 0.001). Moreover, overexpression induced lipid peroxidation 0.01), GPX4 downregulation ferroptosis as revealed by intracellular iron ACSL4/TFRC/Ferritin modulation. In addition, levels SLC7A11 mRNA protein, predicted bioinformatic tools, were suppressed miR-148a-3p's overexpression. On contrary, boosted gene ferroptosis. Together, these vitro findings reveal that can function targeting activating ferroptosis, opening new perspectives rationale therapeutic strategies through miR-148a-3p/SLC7A11 pathway.

Language: Английский

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Unlock the power of bovine milk-derived exosomes for degenerative diseases associated with aging

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 109, P. 105788 - 105788

Published: Sept. 15, 2023

Bovine milk-derived exosomes (BMDEs) have emerged as a fruitful area of investigation in age-related disease therapeutics. Through the utilization BMDEs, researchers possess capacity to unveil novel treatments and therapeutic interventions that potential enhance quality life for elderly individuals across globe. Studies provided evidence efficacy BMDEs facilitating regenerative processes bone cartilage, thus establishing their viable avenue addressing conditions like osteoarthritis. Although show promise prospective research route tackling illnesses, including Parkinson's disease, osteoporosis, skin rejuvenation, other unanswered questions still demand more exploration. Concerns been raised regarding safety especially human administration, must carefully examine these concerns identify alternatives. In conclusion, are an ripe into prevention treatment diseases.

Language: Английский

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Impact of milk and dairy consumption on the development and progression of breast cancer

journal of nutritional oncology, Journal Year: 2024, Volume and Issue: 9(4), P. 112 - 118

Published: Dec. 1, 2024

Abstract Recent studies have shown a link between the consumption of bovine milk and human breast cancer, apparently by agonizing estrogen receptor (ER), which results in proliferation tissues, leading to formation tumor. Bovine may also promote tumor via insulin-like growth factor-1 (IGF-1) signaling. In addition, numerous potentially carcinogenic compounds been found milk, including exosomal microRNAs (miR-148a-3p, miR-21-5p), aflatoxin M1, bisphenol A, pesticides, micro- nanoplastics. Subjects with specific genetic mutations (e.g., BRCA 1 loss-of-function) polymorphisms FTO IGF-1 upregulation) that enhance IGF-1/mTORC1 signaling might be especially susceptible ER+ cancer promoted dairy products. However, previous large-scale meta-analyses, data about processing methods, such as pasteurization ultra-high temperature treatment, are lacking, thus limiting accuracy risk assessments. Clearer more convincing evidence, detailed information, regarding timing exposure (consumption) required because current evidence suggests dietary recommendations need reevaluated.

Language: Английский

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