Levels of neurotrophins in the brain of female rats in an experimental model of malignant tumor growth under conditions of hypothyroidism DOI Creative Commons
Е. И. Сурикова, E. M. Frantsiyants, В. А. Бандовкина

et al.

Research and Practical Medicine Journal, Journal Year: 2023, Volume and Issue: 10(3), P. 43 - 54

Published: Aug. 11, 2023

Objective . Studying the levels of brain-derived neurotrophic factor (BDNF), nerve growth (NGF-β), and neurotrophin 3 (NT3) in cerebral cortex subcortical substance female rats an experimental model extracerebral malignant tumor under conditions induced hypothyroidism. Materials methods An experiment was performed on 47 white non-linear rats: 10 each intact group, control group 1 (induced hypothyroidism), 2 (subcutaneous Guerin’s carcinoma), main (combination pathologies); 7 with subcutaneous to assess life expectancy. Hypothyroidism by per os administration thiamazole (mercazolil, Akrikhin, Russia), daily dose 2.5 mg/100 g body weight, course 30 days; total thyroxine thyroid stimulating hormone were determined blood serum RIA (Immunotech, Czech Republic). When persistent hypothyroidism achieved, carcinoma transplanted skin as standard. Aſter decapitation 18th day aſter transplantation, content BDNF, NGF-β, NT3 (R&D System, RayBiotech, USA) % homogenates subcortex brain USA). Results In groups 2, level BDNF 2.6- 1.6-fold lower, respectively, NGF-β 2.2-fold higher average than group. 3.0- lower substance, respectively. matter 2.4-fold 3.1-fold, only 1.7 times, values being intermediate between corresponding 2. Conclusion Changes all neurotrophins most pronounced cortex, while independent growth, changed most. pathologies combined, altered substance. Apparently, there is interaction CNS changes balance regulatory signals areas brain, that reflecting connection biological characteristics active or inhibited (in presence hypothyroidism) growth.

Language: Английский

Causal association of circulating cytokines with sepsis: a Mendelian randomization study DOI Creative Commons
Shan Lin, Xueyan Mao,

Wanmei He

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 17, 2023

Observational studies have reported an association between circulating cytokines and sepsis. However, the precise causal relationship these factors remains unclear. The objective of this study was to explore link sepsis using genetic data within framework Mendelian Randomization (MR).We performed a two-sample MR analysis investigate causality in individuals European ancestry. publicly available genome-wide (GWAS) statistics were used. We selected eligible instrumental single nucleotide polymorphisms (SNPs) that significantly related cytokines. Multiple approaches carried out, which included inverse variance weighted (IVW), Weighted Median, MR-Egger, Mode, Simple pleiotropy residual sum outlier (MR-PRESSO) methods.We found evidence support role genetically predicted levels on decreased risk sepsis, including RANTES (OR = 0.920, 95% CI: 0.849-0.997, P 0.041) basic fibroblast growth factor (basic-FGF) 0.869, 0.766-0.986, 0.029). Additionally, positive beta-nerve (β-NGF) 1.120, 1.037-1.211, 0.004). results Mode methods consistent with IVW estimates. Sensitivity showed no horizontal bias estimates.This provides first novel RANTES, basic-FGF, β-NGF altered risk. findings shed light potential involvement pathogenesis. Although requiring additional confirmation, contribute new insights into cytokine mediators suggest promising future research directions.

Language: Английский

Citations

8
The Role of Neuro-Immune Interactions in the Pathology and Pathogenesis of Allergic Rhinitis DOI

Ya-An Lan,

Jia-Xi Guo,

Minhua Yao

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(7), P. 1013 - 1029

Published: July 23, 2024

Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving variety immune cells such as mast cells. In previous studies, AR was considered an isolated system. However, recent studies have found that nervous system closely related to development AR. Bidirectional communication between systems plays important role in

Language: Английский

Citations

1
Causal Association Between Heart Failure and Sepsis: Insights from Mendelian Randomization and Observational Studies DOI Creative Commons

Linqiong Liu,

Pengfei Huang, Changsong Wang

et al.

Clinical Epidemiology, Journal Year: 2024, Volume and Issue: Volume 16, P. 755 - 767

Published: Nov. 1, 2024

Purpose: We aimed to identify the association between heart failure (HF) with sepsis and its mortality through Mendelian randomization (MR) observational studies. Patients Methods: In MR study, we utilized public summary statistics from genome-wide studies (GWAS). conducted univariable, multivariable network analyses investigate causal relationships HF sepsis, mediating roles of cytokines growth factors. performed an analysis using MIMIC-IV database. Propensity score matching (PSM) logistic regression models were employed explore besides short-, medium-, long-term associated sepsis. Results: univariable analysis, there was a relationship genetically predicted (OR = 1.15, 95% CI 1.02– 1.29, P 0.025) analyses, βNGF independently And it mediated 17.6% (95% 2.45– 30.72%) effect on real-world acute chronic diastolic (congestive) (DCHF) 1.59, 1.31– 1.93, < 0.001), DCHF 2.52, 1.61– 3.95, 0.010), (DHF) 1.52, 1.06– 2.19, 0.024) after PSM occurrence Chronic systolic (SCHF) increased 28-day 1.75, 2.91, 0.030), 1-year 1.80, 1.08– 3.00, 0.023), 2-year 1.86, 1.12– 3.10, 0.018) in Conclusion: Observational showed SCHF related short/long-term Our study indicated key factor HF-induced Keywords: βNGF, MIMIC-IV, PSM, GWAS

Language: Английский

Citations

0
Psychoneuroimmune Aspects of Atopic Dermatitis DOI
Liborija Lugović‐Mihić

Integrated science, Journal Year: 2024, Volume and Issue: unknown, P. 629 - 654

Published: Jan. 1, 2024

Language: Английский

Citations

0
Levels of neurotrophins in the brain of female rats in an experimental model of malignant tumor growth under conditions of hypothyroidism DOI Creative Commons
Е. И. Сурикова, E. M. Frantsiyants, В. А. Бандовкина

et al.

Research and Practical Medicine Journal, Journal Year: 2023, Volume and Issue: 10(3), P. 43 - 54

Published: Aug. 11, 2023

Objective . Studying the levels of brain-derived neurotrophic factor (BDNF), nerve growth (NGF-β), and neurotrophin 3 (NT3) in cerebral cortex subcortical substance female rats an experimental model extracerebral malignant tumor under conditions induced hypothyroidism. Materials methods An experiment was performed on 47 white non-linear rats: 10 each intact group, control group 1 (induced hypothyroidism), 2 (subcutaneous Guerin’s carcinoma), main (combination pathologies); 7 with subcutaneous to assess life expectancy. Hypothyroidism by per os administration thiamazole (mercazolil, Akrikhin, Russia), daily dose 2.5 mg/100 g body weight, course 30 days; total thyroxine thyroid stimulating hormone were determined blood serum RIA (Immunotech, Czech Republic). When persistent hypothyroidism achieved, carcinoma transplanted skin as standard. Aſter decapitation 18th day aſter transplantation, content BDNF, NGF-β, NT3 (R&D System, RayBiotech, USA) % homogenates subcortex brain USA). Results In groups 2, level BDNF 2.6- 1.6-fold lower, respectively, NGF-β 2.2-fold higher average than group. 3.0- lower substance, respectively. matter 2.4-fold 3.1-fold, only 1.7 times, values being intermediate between corresponding 2. Conclusion Changes all neurotrophins most pronounced cortex, while independent growth, changed most. pathologies combined, altered substance. Apparently, there is interaction CNS changes balance regulatory signals areas brain, that reflecting connection biological characteristics active or inhibited (in presence hypothyroidism) growth.

Language: Английский

Citations

0