A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis—A Cross-Sectional Study

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 22 - 22

Published: Jan. 10, 2025

Objective. To investigate the relationships among neuropathic pain (NP), catastrophizing (PC), and central sensitization (CS) in relation to functional status radiological damage patients with knee osteoarthritis (OA). Methods. This cross-sectional study included OA derived from an observational cohort. The Spearman correlation test was used analyze relationship between Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) PainDetect Questionnaire (PDQ), Central Sensitization Inventory (CSI), Pain Catastrophizing Scale (PCS). Kruskal-Wallis employed compare WOMAC scores according CSI categories. A multivariate analysis conducted identify predictors of ability, score as dependent variable independent variables including pain-related indices such PCS, PDQ, CSI, along Kellgren-Lawrence (K-L) grading demographic characteristics. Results. 149 (76.5% female; mean age 71.5 years; duration 8.1 years). In total, 23.5% exhibited NP, 30.9% showed PC, 33.6% had CS. Higher values were correlated categories (p < 0.0001). a significant (rho = 0.791; p 0.0001), PDQ 0.766; PCS 0.536; multiple regression analysis, independently associated PC No association observed K-L other variables. Conclusions. reduced capacity is presence CS, without being significantly damage.

Language: Английский

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Coixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Osteoarthritis (OA) is a chronic multifactorial disease characterized by cartilage degeneration, pain, and reduced mobility. Current therapies primarily aim to relieve pain restore function, but they often have limited effectiveness side effects. Coixol, bioactive compound from Coix lacryma-jobi L., exhibits anti-inflammatory analgesic properties, suggesting potential benefits in OA treatment. This study explored the effects of coixol on chondrocytes. Primary chondrocytes rats were isolated treated with varying concentrations coixol. Cell viability proliferation assessed using CCK-8 assays. The expression genes related ferroptosis autophagy was analyzed through RT-qPCR, Western blot, immunofluorescence. Moreover, investigated characteristics performance coixol-loaded PDLLA–PEG-PDLLA (PLEL)/gelatin sponge (GS) hydrogels (Coixol@PLEL/GS) for enhancing osteochondral defect repair specifically targeting chondrocyte autophagy. PDLLA–PEG-PDLLA/gelatin evaluated cryo-scanning electron microscopy (SEM) or SEM, release kinetics determined. In vivo, rat model used assess efficacy Coixol@PLEL/GS International Cartilage Repair Society (ICRS) scores, Safranin O/Fast green staining, Toluidine blue Coixol significantly increased dose-dependent manner. Furthermore, inhibited stimulated autophagy, as evidenced upregulation genes. remarkably enhanced defects compared that control groups. conclusion, protects improving survival, inhibiting ferroptosis, activating highlighting its therapeutic strategy

Language: Английский

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Long-Term Efficacy of Carboxymethyl-Chitosan in Advanced Knee Osteoarthritis: A Twelve-Month Follow-Up Study on Non-Responders to Hyaluronic Acid

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 270 - 270

Published: Jan. 22, 2025

Background: Knee osteoarthritis (OA) is a prevalent degenerative joint disease characterized by the degeneration of cartilage. OA leads to pain, stiffness, swelling, and decreased mobility, significantly impacting quality life affected people. Advanced-stage often necessitates surgical intervention due poor response conventional treatments, such as intra-articular hyaluronic acid (HA). Carboxymethyl-chitosan (CM-C), an emerging therapeutic agent, has shown potential in reducing inflammation, improving lubrication, enhancing function. This study aimed evaluate long-term efficacy CM-C injections patients with advanced knee osteoarthritis, non-responders HA. Methods: retrospective included 16 (mean age: 79.56 years) Kellgren–Lawrence grade 3–4 treated single injection CM-C. Pain functional outcomes were assessed using Visual Analogue Scale (VAS) Injury Osteoarthritis Outcome Score (KOOS) at baseline (T0), one month (T1), three months (T2), six (T3), twelve (T4). Results: Significant pain reduction was observed early follow up, (VAS: T1 p = 0.0002, T2 0.0265; KOOS Pain: 0.0014). However, partially returned T3 T4. activities daily living (p 0.0005), QoL 0.0396), Sport Free Time 0.0367) subscales showed significant improvement T1, though worsening trends subsequent up raw values suggesting persistent benefits. Strong negative correlations found between VAS various ups. Conclusions: A demonstrated relief for effects may diminish over time, necessitating careful consideration re-treatment strategies or combined therapies.

Language: Английский

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Manual Tibial Distraction in Seated Position for Identification of Intra-articular Knee Joint Lesions: A Case Report Presenting a Novel Clinical Special Test

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

The meniscus is a weight-bearing, intra-articular, fibrocartilaginous structure that frequently injured. Traditional special tests for diagnosis of intra-articular lesions the knee involve provocative with compressive or torsional components, often leading to increased pain. With this case study, we aim introduce Tibial Distraction Test (TDT), novel clinical test assessment joint lesions, including injury and osteoarthritis (OA), without provoking A 30-year-old man presented clinic right pain swelling two months duration following forceful extension internal rotation motion which led catch then audible pop discomfort. patient's initial included McMurray's test, line palpation, Apley's compression positive results each test. second examiner, blinded examination, assessed patient using proposed TDT. reported relief, indicating result. Subsequent magnetic resonance imaging (MRI) confirmed medial tear. Arthroscopy showed full-thickness meniscal tear debridement was performed. At one month's follow-up, returned baseline function resolution symptoms. Diagnosing requires thorough history painful in already presenting as primary complaint. Our presents manual seated position appears be pain-relieving may used assess lesions.

Language: Английский

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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 391 - 404

Published: Jan. 1, 2025

Knee osteoarthritis (KOA) is a prevalent degenerative bone and joint disease observed in clinical practice. While acupuncture has demonstrated efficacy treating KOA, the central mechanisms underlying its effects remain ambiguous. Recently, functional magnetic resonance imaging (fMRI) been extensively applied studying brain of analgesia. Currently, network analysis based on connectomics focal point research. Therefore, this study uses KOA as research vehicle, focuses abnormal connectivity patterns networks, integrates pain assessments to thoroughly investigate therapeutic KOA. In parallel, randomized, sham-controlled neuroimaging trial, 60 patients will be randomly divided into group sham 1:1 ratio, treated three times weekly for total 12 sessions. Patients undergo symptom cranial fMRI scans at baseline (-1-0 weeks), post-treatment (4 follow-up (16 weeks). Forty healthy subjects recruited observation, with single MRI scan conducted only week). The primary indicator change NRS score after four weeks treatment, secondary outcomes including WOMAC, STAI, safety assessments. observations employ independent component analysis, construction, connectivity, complemented by Pearson correlation explore relationship between responses improvements. This initially uncover how intervention chronic centrally regulates exerts through modulation patterns, long-term effect. approved ethics committee Shandong University Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY). registered Clinical Trial Registry (ChiCTR2400083695).

Language: Английский

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