The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

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Endocrine–circadian interactions in birds: implications when nights are no longer dark

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1898)

Published: Feb. 5, 2024

Biological clocks are evolved time-keeping systems by which organisms rhythmically coordinate physiology within the body, and align it with rhythms in their environment. Clocks highly sensitive to light at interface of several major endocrine pathways. Worryingly, exposure artificial-light-at-night (ALAN) is rapidly increasing ever more extensive parts world, likely impact on wild mediated endocrine-circadian In this overview, we first give a broad-brush introduction biological rhythms. Then, outline interactions between avian clock, pathways, environmental internal modifiers. The main focus review circadian hormone, melatonin. We summarize information from field laboratory studies melatonin its relationships behaviour physiology, including often neglected developmental aspects. When exposed ALAN, birds vulnerable disruption behavioural physiological under rhythmic control. Several suggest that key mediator for broad range effects. encourage further observational experimental ALAN melatonin, across full functional versatile signalling molecule, as well other candidate compounds interface. This article part theme issue 'Endocrine responses variation: conceptual approaches recent developments'.

Language: Английский

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I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Modern habits are becoming more and disruptive to health. As our days often filled with circadian disruption stress exposures, we need understand how responses these external stimuli shaped their mediators can be targeted promote A growing body of research demonstrates the role gut microbiota in influencing brain function behavior. The response rhythms, which essential maintaining appropriate environment, known impacted by microbiota. Gut microbes have been shown alter host's modulate rhythmicity. Although studies demonstrated strong links between microbiota, rhythms response, such were conducted an independent manner not conducive understanding interface factors. Due interconnected nature this review explore may play a regulating integration signals mammals consequences for health disease.

Language: Английский

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Real-ambient bedroom light at night increases systemic inflammation and disrupts circadian rhythm of inflammatory markers

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116590 - 116590

Published: June 20, 2024

Exposure to light at night (LAN) has been associated with multiple adverse health outcomes. However, evidence is limited regarding the impacts of LAN exposure on human inflammation. To examine association between real-ambient bedroom systemic inflammation and circadian rhythm inflammatory markers. Using data from a prospective cohort study Chinese young adults. At baseline, was measured portable illuminance meter; fasting blood sample for high-sensitivity C-reactive protein (hs-CRP) assay collected. 3-year follow-up, 20 healthy adults (10 LANavg < 5 lx, 10 ≥ lx) were recruited same cohort; time-series venous samples sampled every 4 h over 24 h-cycle detection 8 Circadian markers assessed using cosinor analysis. average age 276 participants 18.7 years, 33.3 % male. Higher levels significantly increased hs-CRP levels. The only significant in inactive group (MVPA 2 h/d) but not physically active h/d). In addition, higher nighttime (LANavg disrupted rhythms (including rhythmic expression, amplitude phase) some cytokines balance indicators. increases disrupts Keep darkness may represent important strategies prevention chronic Additionally, people living community pollution, regular physical activity be viable option counteract negative

Language: Английский

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Dim blue light at night worsens high-fat diet-induced kidney damage via increasing corticosterone levels and modulating the expression of circadian clock genes

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117636 - 117636

Published: Jan. 1, 2025

Obesity is a contributing factor that increases the likelihood of developing chronic kidney disease. In recent years, studies have found light pollution worldwide promoted obesity, which was known to be consequence circadian rhythm disruption. Nevertheless, impact on disease associated with obesity remains mostly unknown, and potential processes been minimally investigated. Herein, we fed mice high-fat diet gave them dim white (dWL), blue (dBL), green (dGL), red (dRL) for 12 weeks. Our results showed both dWL dBL tended more susceptible damage dysfunction caused by compared LD, pronounced changes in dBL. The analysis activated TGF-β1/Smad signaling pathway promote epithelial-mesenchymal transition (EMT) kidney. Additionally, NF-κB resulted elevated protein levels TLR4, p-IκB, p-P65, TNF-α. Furthermore, increased BAX decreased BCL2 levels. At same time, affected Keap1/Nrf2/HO-1 pathway, elevating KEAP1 decreasing NRF2 HO-1 We were surprised find altered expression clock genes, resulting decrease positively regulated genes Bmal1, Clock, an increase negatively Per1, Per2, Per3. Mechanistically, plasma CORT as well renal GR α expression, vitro experiments addition returned normal after inhibitor RU486. Consequently, can exacerbate injury altering rhythmic acting biological via GR.

Language: Английский

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Investigating the behavioral implications of microplastic exposure in animal species

Annals of Animal Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Microplastics (MPs) are pervasive pollutants impacting ecosystems worldwide, causing physical harm and behavioral changes in wildlife. MP toxicity mainly depends on size, porosity, weathering, surrounding compounds. MPs disrupt feeding metabolism, resulting reproductive, neurological, disorders. These impacts significantly alter ecological niches reduce animal survival. Understanding these is crucial for assessing the broader effects of plastic pollution developing effective mitigation strategies. This review investigated 110 papers quantifying consequences while considering their_physiological basis, emphasizing significance their potential long-term influence populations ecosystems. study thoroughly investigates model species, including plankton, fish, amphibians, crustaceans, pollinators, mammals. Fish exhibited most significant impact, crustaceans showed least. Mice, representing mammals, displayed severe physiological damage.

Language: Английский

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Endocrine regulation of circadian rhythms

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 8, 2025

Abstract Circadian clocks are internal timekeepers enabling organisms to adapt recurrent events in their environment – such as the succession of day and night—by controlling essential behaviors food intake or sleep-wake cycle. A ubiquitous cellular clock network regulates numerous physiological processes including endocrine system. Levels several hormones melatonin, cortisol, sex hormones, thyroid stimulating hormone well a number metabolic factors vary across day, some them, turn, can feedback on circadian rhythms. In this review, we dissect principal ways by which regulate rhythms target tissues phasic drivers rhythms, zeitgebers resetting tissue phase, tuners, affecting downstream more tonic fashion without core clock. These data emphasize intricate interaction system offer inroads into tissue-specific manipulation organization.

Language: Английский

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Counteracting the effects of artificial light at night: The role of melatonin in brain plasticity and nighttime activity in a songbird

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 975, P. 179251 - 179251

Published: April 3, 2025

Melatonin is important for synchronizing biological rhythms and regulating behavioral, physiological, neurobiological circadian processes. Therefore, it a good candidate investigating the consequences of artificial light at night (ALAN), which major global pollutant reduces nighttime melatonin levels. The negative effects ALAN on health biodiversity are thoroughly studied, however less known about its adult brain plasticity (ABP). This study investigated role in mediating ABP behavior zebra finches (Taeniopygia guttata). Birds were exposed to control (dark nights) or (5 lx) conditions treated with via skin cream. We measured locomotor activity (NMA), plasma levels, parameters: cell proliferation ventricular zone, neuronal recruitment, apoptosis, total densities three forebrain regions: nidopallium caudale (NC), medial striatum (MSt), hippocampus (HC). alone reduced melatonin, increased NMA, proliferation, apoptosis MSt NC but not HC, appeared more resilient. However, when treatments combined ALAN, generally counteracted NMA ABP, except remained resilient even under treatments. Our findings suggest that can counteract ALAN-induced changes behavior. Further research (e.g. wild species lifelong ALAN-exposed birds) needed evaluate these results an ecological context, be used nature conservation efforts.

Language: Английский

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Interactive effects of light at night and high fructose intake on the central circadian clock and endocrine outputs in rats

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112559 - 112559

Published: April 1, 2025

Language: Английский

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Exposure to real-ambient bedroom light at night delayed circadian rhythm in healthy Chinese young adults: A cross-sectional study

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118657 - 118657

Published: March 21, 2024

Language: Английский

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