Tumor Microenvironment and Dermatological Conditions in Prostate Cancer DOI Creative Commons
Corina Daniela Ene, Cristina Căpușă, Ilinca Nicolae

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(21), P. 9655 - 9655

Published: Oct. 22, 2024

Tumor initiation, progression, and invasion are closely related to the tumor microenvironment. Inflammation can modulate activity of cells in TME contribute all stages development. The etiopathogenesis cutaneous manifestations associated with prostate cancer is unclear. phenotype could be supported by intratumoral heterogeneity, remodeling interactions microenvironment, dynamics epithelial–mesenchymal transition. Among urinary system cancers, presents few signs symptoms, most being diagnosed advanced disease. In this review, we analyze events cancer, represented direct or indirect primary malignancy skin toxicities caused oncological medications.

Language: Английский

Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target DOI Creative Commons
Chao Xu,

Litao Liang,

Guoqing Liu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 5, 2025

Abstract Background Hepatocellular carcinoma (HCC) continues to be a major cause of cancer-related death worldwide, primarily due delays in diagnosis and resistance existing treatments. Recent research has identified ATP-dependent chromatin remodeling-related genes (ACRRGs) as promising targets for therapeutic intervention across various types cancer. This development offers potential new avenues addressing the challenges HCC management. Methods study integrated bioinformatics analyses experimental approaches explore role ACRRGs HCC. We utilized data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), applying machine learning algorithms develop prognostic model based on ACRRGs’ expression. Experimental validation was conducted using quantitative real-time Polymerase Chain Reaction (qRT-PCR), Western blotting, functional assays cell lines xenograft models. Results Our analysis four key ACRRGs—MORF4L1, HDAC1, VPS72, RUVBL2—that serve markers developed risk prediction effectively distinguished between high-risk low-risk patients, showing significant differences survival outcomes predicting responses immunotherapy patients. Experimentally, MORF4L1 demonstrated enhance cancer stemness by activating Hedgehog signaling pathway, supported both vitro vivo assays. Conclusion ACRRGs, particularly MORF4L1, play crucial roles modulating progression, offering insights into molecular mechanisms driving targets. findings advocate inclusion remodeling dynamics strategic precision therapies

Language: Английский

Citations

0
3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells DOI
Mahima Verma, Shireen Fatima, Asad Syed

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Language: Английский

Citations

0
Translating Preclinical Insights into Clinical Strategies: Targeting Cancer Stem Cells and Stemness in Prostate Cancer DOI
Najma Farahani,

Amin Maghsoodlou,

Mohammadarian Akbari

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155934 - 155934

Published: March 1, 2025

Language: Английский

Citations

0
Red deer (Cervus elaphus L.) antler stem cell culture medium inhibits prostate cancer cells DOI
Marta Zarzycka, Anna Korzekwa, Joanna Dulińska-Litewka

et al.

Histochemistry and Cell Biology, Journal Year: 2025, Volume and Issue: 163(1)

Published: April 2, 2025

Language: Английский

Citations

0
Pathology and treatment for prostate cancer: Based on prostate stem cells and cell therapy DOI
Zhiwei He

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: May 10, 2025

Prostate cancer is a major global health concern, with current treatments limited by resistance and recurrence in advanced stages. stem cells (PCSCs) are key drivers of tumor progression therapy due to their self-renewal, differentiation capabilities, interactions the microenvironment. This review examines role PCSCs explores therapeutic strategies target them, including inhibitors signaling pathways (Wnt, Hedgehog, Notch, NF-κB, PI3K/mTOR), gene editing technologies like CRISPR-Cas9, cell-based therapies such as chimeric antigen receptor (CAR)-T mesenchymal cell-derived exosomes. Despite potential, these approaches face challenges clinical translation, heterogeneity, immunosuppressive microenvironment, safety concerns. Ongoing research trials should aim overcome hurdles improve prostate treatment outcomes.

Language: Английский

Citations

0
N-terminal domain of androgen receptor is a major therapeutic barrier and potential pharmacological target for treating castration resistant prostate cancer: a comprehensive review DOI Creative Commons
Ye Chen, Tian Lan

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

The incidence rate of prostate cancer (PCa) has risen by 3% per year from 2014 through 2019 in the United States. An estimated 34,700 people will die PCa 2023, corresponding to 95 deaths day. Castration resistant (CRPC) is leading cause among men with PCa. Androgen receptor (AR) plays a critical role development CRPC. N-terminal domain (NTD) essential functional for AR transcriptional activation, which modular activation function-1 (AF-1) important gene regulation and protein interactions. Over last 2 decades drug discovery against NTD attracted interest CRPC treatment. However, an intrinsically disordered without stable three-dimensional structure, so far hampered drugs targeting this highly dynamic structure. Employing high throughput cell-based assays, small-molecule inhibitors exhibit variety unexpected properties, ranging specific binding NTD, blocking transactivation, suppressing oncogenic proliferation, prompts its evaluation clinical trials. Furthermore, molecular dynamics simulations reveal that compounds can induce formation collapsed helical states. Nevertheless, our knowledge structure been limited primary sequence amino acid chain few secondary motif, acting as barrier computational pharmaceutical analysis decipher conformation drug-target interaction. In review, we provide overview on sequence-structure-function relationships including polymorphism mono-amino repeats, elements transcription regulation, modeled tertiary NTD. Moreover, summarize activities therapeutic potential current NTD-targeting outline different experimental methods contributing screening novel compounds. Finally, discuss directions structure-based design breakthroughs exploring pharmacological motifs pockets could contribute new inhibitors.

Language: Английский

Citations

1
Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven Seven-Gene Stemness Signature That Predicts Progression DOI Open Access
Agustina Sabater, Pablo Sanchis, Rocio Seniuk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11356 - 11356

Published: Oct. 22, 2024

Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate (NEPC). This study developed and validated stemness-associated gene signature using advanced machine learning techniques, including Random Forest Lasso regression, applied large-scale transcriptomic datasets. The resulting seven-gene (KMT5C, DPP4, TYMS, CDC25B, IRF5, MEN1, DNMT3B) was across independent cohorts patient-derived xenograft (PDX) models. demonstrated strong prognostic value for progression-free, disease-free, relapse-free, metastasis-free, overall survival. Importantly, the not only identified specific NEPC subtypes, such as large-cell carcinoma, which is associated with very poor outcomes, but also predicted prognosis PCa cases that exhibit this molecular signature, even when they were histopathologically classified NEPC. dual classifier capability makes robust tool personalized medicine, providing valuable resource predicting disease guiding treatment strategies in management.

Language: Английский

Citations

1
Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy DOI Creative Commons
Hao Liang, Bin Zhou, Pei-Xin Li

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 57(1)

Published: Dec. 23, 2024

Background Increasing evidence indicates that cancer stem cells (CSCs) and stem-like form a special subpopulation of are ubiquitous in tumors. These exhibit similar characteristics to those normal tissues; moreover, they capable self-renewal differentiation, as well high tumorigenicity drug resistance. In prostate (PCa), it is difficult kill these using androgen signaling inhibitors chemotherapy drugs. Consequently, the residual (PCSCs) mediate tumor recurrence progression.

Language: Английский

Citations

1
Mosaic Neuroendocrine-/Adenocarcinoma of the Prostate: Clinical and Histological Description DOI Open Access

Kálmán Almási,

Noémi Kránitz,

Tamás Kullmann

et al.

Published: Sept. 14, 2023

Background: Mosaic cancers are composed of two or several genetically different cell populations. Mosaicism has been considered to be rare among malignancies, with the exception germ tumours. Although it described that neuroendocrine foci may present within an adenocarcinoma prostate, this was ment for advanced stage disease and clinical relevance histological finding not clarified. Patients methods: We recently published analysis a small cohort patients who had cancer prostate. Contrarily general assumption poor prognosis, incidence found 2%, being 50 fold higher than earlier data. During follow-up overall survival some metastatic reached years. The particularity favourable outcome parallel elevation PSA NSE. They received anticancer treatments in alternating way directed according tumour marker rise. aim paper is show pathological background our observations. Results: Histological images de novo mosaic prostate shown. A model explaining development presented. hypothesis mosaicism adenocarcinomas formulated addition. Conclusion: neuroendocrine-/adenocarcinoma underestimated regarding its as well prognosis.

Language: Английский

Citations

1
Primary Mosaic Neuroendocrine-/Adenocarcinoma of The Prostate: Clinical and Histological Description DOI Open Access

Kálmán Almási,

Noémi Kránitz,

Tamás Kullmann

et al.

Published: Nov. 9, 2023

Background: Mosaic cancers are composed of two or several genetically different cell populations. Mosaicism has been considered to be rare among malignancies, with the exception germ tumours. Although it described that neuroendocrine foci might present within adenocarcinomas prostate, this was meant for advanced stage diseases and clinical relevance histological finding not clarified. Patients methods: We recall a single centre cohort patients cancer prostate. show first time images primary mosaic neuroendocrine/adenocarcinoma Results: Contrarily general assumption disease poor prognosis, incidence found 2%, being 50 fold higher than earlier data. During follow-up overall survival some metastatic reached years. The particularity favourable outcome parallel elevation PSA NSE. They received anticancer treatments in an alternating way directed according tumour marker actually rise. Histological prostate shown. A model explaining development is presented. Conclusion: neuroendocrine-/adenocarcinoma underdiagnosed its prognosis underestimated.

Language: Английский

Citations

1