Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(23), P. 11402 - 11402
Published: Dec. 7, 2024
Mixed
systems
based
on
ionic
liquids
are
promising
innovative
solvents
due
to
their
properties,
which
strictly
connected
the
interactions
that
arise
among
components.
The
present
work
investigates
intermolecular
of
a
mixed
choline
acetate
and
maleic
acid
system
modifications
with
increasing
content.
MM/DFT
calculations
provided
indications
about
possible
geometric
configurations
while
Non-Covalent
Interaction
analysis
was
useful
describe
distinguish
secondary
interactions.
number
available
decreases
at
high
concentration.
Moreover,
intramolecular
hydrogen
bonding
observed
in
all
except
most
stable
one
lowest
content
mixture.
Concomitantly,
far-infrared
spectroscopy
used
investigate
support
computational
results.
Current Opinion in Electrochemistry,
Journal Year:
2024,
Volume and Issue:
45, P. 101465 - 101465
Published: Feb. 24, 2024
This
review
concerns
deep
eutectic
solvents
(DES)
and
how
they
can
be
exploited
in
the
preparation
of
new
improved
electrochemical
sensing
platforms.
Some
relevant
properties
DES
are
described,
with
a
brief
description
range
applications
recent
advances
concerning
coatings
materials
prepared
DES.
Their
use
modified-electrode
sensors
biosensors
publications
is
then
addressed,
particularly
regarding
electroactive
redox
polymer-modified
electrodes,
together
nanomaterials,
including
employing
ternary
to
increase
sensitivity.
Future
perspectives
indicated.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 300 - 300
Published: Feb. 25, 2025
Over
the
past
twenty
years,
ionic
liquids
(ILs)
and
deep
eutectic
solvents
(DESs)
have
gained
recognition
across
various
fields,
including
catalysis,
extraction
purification,
materials
science,
biotechnology.
Notably,
use
of
ILs
DESs
in
pharmaceutical
research,
especially
drug
delivery,
has
seen
remarkable
expansion
over
decade.
This
review
offers
a
comprehensive
analysis
specifically
designed
for
oral
administration
drugs
having
unfavorable
biopharmaceutical
properties.
The
classification
characteristics
DESs,
along
with
their
newer
natural
(Bio-ILs
NaDESs)
therapeutic
subcategories
(API-ILs
TheDESs)
are
outlined.
Additionally,
further
subgroup
ILs,
known
as
surface
active
(SAILs),
is
described.
Then,
detailed
examination
available
manufacturing
methods
sustainable,
time-consuming,
scalable
perspective,
toxicity
concerns
relation
to
subdivision
evaluated.
Finally,
specific
applications
whether
used
neat
or
converted
into
administrable
dosage
forms,
analyzed
discussed.
Despite
significant
advancements
recent
years
regarding
these
there
still
many
aspects
that
need
investigation.
These
include
interaction
biological
systems
(gastrointestinal
fluids
mucosa),
long-term
stability,
development
effective
delivery
systems.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(14)
Published: Feb. 4, 2024
Abstract
Deep
eutectic
solvents
(DESs)
have
been
intensively
investigated
in
recent
years
for
their
antibacterial
properties,
with
DESs
that
comprise
organic
acids
(OA‐DESs)
showing
promising
action.
However
a
majority
of
the
reports
focused
only
on
limited
number
strains
and
techniques,
which
is
not
enough
to
determine
potential
substance.
To
bridge
this
gap,
activity
classical
OA‐DESs
assessed
twelve
Gram‐negative
Gram‐positive
bacteria
strains,
some
them
exhibiting
specific
resistance
toward
antibiotics.
The
formulations
glycolic,
malic,
malonic,
oxalic
as
representatives
group.
Using
range
microbiological
assays
well
physicochemical
characterization
methods,
major
difference
effectiveness
between
two
groups
demonstrated,
exhibiting,
expected,
greater
than
DESs.
Most
interestingly,
slight
differences
minimum
inhibitory
bactericidal
concentration
values
time‐kill
kinetics
profiles
are
observed
strains.
Transmission
electron
microscopy
analysis
reveals
effect
treatment
both
DESs,
allows
us
better
understand
possible
mechanism‐of‐action
these
novel
materials.
