Exposure to Cadmium and its Impacts on Human Health: A Short Review

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100608 - 100608

Published: Jan. 1, 2025

Language: Английский

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The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 20, 2023

The complex and mutually influential connection between diabetes mellitus chronic kidney disease (CKD) is a significant focal point in the current healthcare landscape. Diabetes, medical condition characterized by elevated blood glucose levels resulting from impaired insulin action or secretion, has become global epidemic. It poses considerable challenges to systems affects millions of individuals worldwide. Concurrently, CKD, gradual decline function, persistent health challenge. This narrative review explores relationship these two conditions, shedding light on their implications for public health, clinical practice, biomedical research. correlation not merely coincidental. Diabetes recognized as risk factor with are considerably more vulnerable developing renal complications. Diabetic nephropathy, distinct type closely associated diabetes, end-stage disease. imperative implement efficient management strategies regulate sugar prevent potential damage. On other hand, may contribute development diabetes. kidneys filtering selectively reabsorbing necessary. In compromised such metabolism can give rise resistance As result, plays dual role both preserving function preventing who at risk. coexistence patient presents challenges. Achieving effective requires meticulous balance glycemic control preservation function. Failing maintain this delicate equilibrium lead cardiovascular complications subsequent hospitalizations. comprehensive aims thoroughly examine pathophysiological mechanisms that connect will provide insights into manifestations diagnostic methods, explore various approaches managing condition, discuss crucial nutrition, delve pharmacological interventions, emphasize importance education self-care, shed emerging research areas. addition impacting individual outcomes, reciprocal systems, socioeconomic landscapes, policy. Comprehending interaction making well-informed judgments, improving care, approach address interconnected issues

Language: Английский

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Smoking status, cadmium, and chronic kidney disease

Renal Replacement Therapy, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 18, 2024

Abstract Background Chronic kidney disease (CKD) affects 10% of the general population in Western countries. Currently, CKD cannot be cured and there are only few strategies to prevent onset CKD, reverse early stages progression established end-stage disease. Cigarette smoking is a preventable cause CKD. Methods This narrative review analyses cause–effect relationship between cigarette discusses association inhaled cadmium smoking-induced damage. Results places individuals at risk for incident It accelerates (decline glomerular filtration rate, aggravation proteinuria) (ESKD), associated with shortened transplant graft survival. These harmful effects on function/structure dependent dose duration smoking. Smoking abstinence decreases higher proteinuria progression. Inhaled may biologic link dysfunction. Recent studies indicate that accumulation blood mediates smokers all-cause mortality. Conclusions cessation an effective intervention reduce as well smoking-attributable morbidity

Language: Английский

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Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011–2020

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 13, 2024

Abstract The present study utilized the National Health and Nutrition Examination Survey (NHANES) database to examine relationship between serum levels of heavy metals Diabetic retinopathy (DR) in individuals aged over 30 years with type 2 diabetes mellitus (T2DM) United States. A cross-sectional analysis was conducted on 1583 T2DM from NHANES 2011–2020, including 331 DR group 1252 non-DR group. We collected data metals, DR, albumin for descriptive statistics, linear regression, logistical regression analysis. After adjusting age, gender, race other factors, there no statistically significant association blood cadmium, selenium, mercury, or lead DR. However, manganese (Mn) had a negative (β = − 0.2045, 95% CI 0.3484, 0.0606). Serum partially modulated indirect influence Mn incidence accounting 12.80% There prevalence people T2DM. intake at least this has little onset development

Language: Английский

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The association between low-concentration heavy metal exposure and chronic kidney disease risk through α-klotho

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Language: Английский

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Toxicity effects of cadmium exposure on early development: a review of current evidence

Critical Reviews in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: April 7, 2025

In recent decades, cadmium (Cd) has garnered significant global attention due to its extensive and potentially harmful health effects, even at low exposure levels. Improper management of waste can lead severe environmental pollution, ultimately affecting living organisms through various routes. This study aims compile review the latest data on toxic effects Cd critical body systems functions, with a particular focus early stages development (prepubertal period) across different species. The highlights Cd's impact reproductive, neurobehavioral, cognitive, immune, renal systems, gastrointestinal, endocrine systems. Additionally, it provides valuable insights into how may contribute diseases in later life.

Language: Английский

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Epigenetic alterations in bioaccumulators of cadmium: Lessons from mammalian kidneys and plants

Environment International, Journal Year: 2024, Volume and Issue: 191, P. 109000 - 109000

Published: Sept. 1, 2024

Language: Английский

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The Overlooked Impact of Cadmium on the Progression of Chronic Hepatitis and the Onset of Renal Failure in Advanced Cirrhosis

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127542 - 127542

Published: Oct. 6, 2024

Language: Английский

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Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?

Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 83 - 83

Published: Dec. 30, 2023

Cadmium (Cd) is a pervasive toxic metal, present in most food types, cigarette smoke, and air. Most cells the body will assimilate Cd, as its charge ionic radius are similar to essential metals, iron, zinc, calcium (Fe, Zn, Ca). Cd preferentially accumulates proximal tubular epithelium of kidney, excreted urine when these die. Thus, excretion reflects renal accumulation (body burden) current toxicity Cd. The kidney only organ other than liver that produces releases glucose into circulation. Also, responsible for filtration re-absorption glucose. least recognized diabetogenic substance although research performed 1980s demonstrated effects chronic oral administration neonatal rats. Approximately 10% global population now living with diabetes over 80% overweight or obese. This association has fueled an intense search any exogenous chemicals lifestyle factors could induce excessive weight gain. However, whilst epidemiological studies have clearly linked exposure, this appears be independent adiposity. review highlights exposure sources levels associated type 2 mechanisms by which disrupts metabolism. Special emphasis on roles cellular stress responses defenses, involving heme oxygenase-1 -2 (HO-1 HO-2). From degradation, both HO-1 HO-2 release Fe, carbon monoxide, precursor substrate producing potent antioxidant, bilirubin. also anti-diabetic anti-obese actions. In old age, deficient mice display symptomatic spectrum human diabetes, including hyperglycemia, insulin resistance, increased fat deposition, hypertension.

Language: Английский

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Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?

Published: Nov. 30, 2023

Cadmium (Cd) is a pervasive toxic metal, present in most food types, cigarette smoke, and contaminated air. It has no nutritional or physiological value, but cells the body will assimilate Cd, as its charge ionic radius are similar to essential metals, iron, zinc, calcium (Fe, Zn, Ca), which required for cellular metabolism functional integrity. The kidney regarded principal site of Cd toxicity it preferentially accumulates proximal tubular epithelium here. As these die due accumulation, complexed with metallothionein released into lumen excreted. Excretion signifying current renal cell toxicity, used measure long-term exposure. Approximately 10% global population now living diabetes over 80% overweight obese. This association fueled an intense search any exogenous chemicals life-style factors that could induce excessive weight gain. Whilst epidemiological studies have clearly linked exposure, this appears be independent obesity. Indeed, obesity may enhance diabetogenic effects Cd. review highlights exposure sources levels associated type 2 along pathophysiologic mechanisms by disrupt glucose metabolism. Special emphasis on roles liver homeostasis, heme-glucose cross-talk, involvement heme oxygenase-1 -2 (HO-1 HO-2). From degradation, both HO-1 HO-2 release Fe, carbon monoxide precursor substrate producing cytoprotective biochemical, bilirubin, whilst also anti-diabetic anti-obese actions.

Language: Английский

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