The Role of Systemic Health Indicators, Including C-Reactive Protein and eGFR, in Predicting Periodontal Disease: A Longitudinal Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 741 - 741

Published: Jan. 16, 2025

C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) are key biomarkers reflecting systemic inflammation metabolic dysfunction. This study explored oral health indicators, including CRP eGFR, as potential factors associated with periodontitis, using a longitudinal clinical dataset comprising 23,742 records from patients identified by ICD-10 codes between 2015 2022. Univariate Cox analysis Gompertz models, selected based on AIC BIC after evaluating alternative were employed to assess the predictive roles of eGFR in periodontitis incidence, adjusting for factors. Elevated (>15 mg/L) reduced (<60 mL/min/1.73 m2) significant predictors hazard ratios (HR) 1.36 [1.05–1.77] 1.39 [1.08–1.78], respectively. Atherosclerosis (HR: 2.12 [1.11–4.06]), diseases hard tissues teeth 7.30 [5.45–9.78]), disorders supporting structures 3.02 [2.05–4.43]) also demonstrated strong associations. emerged predicting enabling early interventions prevent tooth loss complications. Patients chronic kidney disease, atherosclerotic heart lipid metabolism at higher risk, emphasizing need integrated care addressing both

Language: Английский

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Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients

Future Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 28, 2025

Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular fibrillation (AF) patients. The population was 1428 patients with AF, 875 of whom enrolled. Based on LAAV, were divided into three groups 262 <25 cm/s, 360 25 to 55 253 >55 cm/s assess compare terms indices, including platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte systemic immune inflammation index, neutrophil - platelet ratio white blood cell-to-platelet (WPR). There no statistical difference level groups, none them related (p > .05) except WPR weak negative correlation = 0.01, r -0.10). Patients lower found have higher age 0.001), decreased ventricular ejection fraction 0.001) greater volume index 0.001). did not show any AF WPR.

Language: Английский

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Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 221 - 234

Published: Jan. 1, 2025

Dyslipidemia is linked to pregnancy complications, but its causal role remains uncertain. This two-sample Mendelian Randomization (MR) study investigated the relationship between lipid traits and complications evaluated impact of lipid-modifying drug targets. Genetic instruments for targets drugs were obtained from Global Lipids Genetics Consortium. Three complications' summary statistics came FinnGen R9 database. Significant underwent further analysis using Expression Quantitative Trait Loci data, mediation identified potential mediators. Increased high-density lipoprotein cholesterol (HDL-C) reduced incidence preeclampsia (OR: 0.755, 95% CI: 0.639-0.891, p=0.001, FDR=0.012) gestational diabetes mellitus (GDM) 0.835, 0.741-0.942, p=0.003, FDR=0.018). proxies cholesteryl ester transfer protein (CETP) inhibition correlated with a decreased risk 0.863, 0.786-0.947, p=0.002, FDR=0.027), while genetic HMG-CoA reductase (HMGCR) increased 1.700, 1.189-2.431, p=0.004, FDR=0.036). Genetically mimicking enhancement lipase (LPL) related GDM 0.681, 0.560-0.829, p=1.29×10-4, FDR=0.004). Higher LPL expression in subcutaneous adipose tissue also 0.642, 0.454-0.909, p=0.013). Waist circumference (4.2%) waist-to-hip ratio adjusted by BMI (5.7%) partially mediated LPL's effect on risk. Elevated HDL-C levels help prevent GDM. CETP could be therapeutic GDM, respectively. However, caution advised HMGCR-targeting drugs, as they may increase

Language: Английский

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The role of C-reactive protein in predicting all-cause mortality among Chinese arthritis patients: implications for public health education and promotion

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

Arthritis poses a significant public health challenge, contributing to increased healthcare resource utilization and reduced quality of life. C-reactive protein (CRP), key inflammatory biomarker, plays critical role in monitoring disease progression guiding promotion strategies. This study aims investigate the association between CRP levels all-cause mortality Chinese arthritis patients, highlighting its implications for education intervention programs. A prospective cohort was conducted using data from China Health Retirement Longitudinal Study (CHARLS) 2011 2020. Individuals diagnosed with were included, as primary exposure variable outcome interest. Kaplan-Meier survival curves Cox proportional hazards regression models employed assess relationship risk, emphasizing potential targeted interventions. total 3,413 participants analyzed, 87 deaths recorded during 10-year follow-up period. Deceased individuals older exhibited higher CRP, creatinine, uric acid, alongside lower BMI, MET, eGFR, HGB. Across three models, elevated (≥3 mg/L) significantly associated risk [hazard ratio (HR) = 3.73 (2.23-6.23), HR 3.00 (1.79-5.01), 4.94 (1.77-13.78), respectively]. further confirmed that patients ≥3 mg/L faced markedly risk. Elevated are strongly underscoring importance integrating into Efforts control inflammation promote literacy regarding management may improve outcomes reduce burden arthritis.

Language: Английский

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The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Sodium-glucose transport protein 2 inhibitors (SGLT2i) have been widely used to treat patients with type diabetes mellitus (T2DM) and demonstrated protective effects against certain cardiovascular diseases. However, no clinical research has conducted explore the relationship between SGLT2i risk of aortic aneurysm (AA). We extracted analyzed data 4964 T2DM from First Affiliated Hospital Zhengzhou University during July 2017 January 2023. Multivariate Cox models, interaction analysis Kaplan–Meier curves were performed approximate associations therapy on AA. A sensitivity was test robustness results. Mediation analyses explored roles inflammatory (neutrophils, lymphocytes, C-reactive alkaline phosphatase) oxidative stress (gamma glutamyl transferase, total bilirubin, uric acid) markers in 1942 SGLT2 inhibitor users (39.12%) 3022 non-SGLT2 (NonSGLT2i) included final analysis. After full adjustment for potential factors, associated a lower (HR, 95% CI 0.91, 0.89–0.98, p = 0.001). Dapagliflozin showed greatest difference reduction incidence 0.84, 0.80–0.95, 0.011). Subgroup indicated that use some subgroups patients. The CRP, neutrophils, acid significantly both AA, mediation proportions 13.35%, 8.83%, 9.67% 31.17%, respectively. Our study suggested using may aneurysm, this effect could potentially be mediated by inflammation stress. Further mechanistic prospective studies are required verify association.

Language: Английский

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Interactive effects of short-term ozone exposure and plasma biomarkers related to nitric oxide pathway and inflammation on myocardial ischemia

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117892 - 117892

Published: Feb. 1, 2025

No study has explored the possible interactive effects of short-term ozone (O3) exposure and plasma endothelial inflammatory biomarkers, including cyclic guanosine monophosphate (cGMP), nitric oxide metabolite (NOx), myeloperoxidase (MPO), high-sensitive C-reactive protein (hs-CRP), on myocardial ischemia, indicated by ST-segment depression events (STDE) recorded in ambulatory electrocardiograms. A L-arginine (L-Arg) intervention with 118 participants was carried out using a standardized 24-h protocol, employing multivariable linear regression model to assess O3 generalized investigate 24-hour STDE. The biomarkers indicators ischemia were also investigated product interaction terms between ambient models. We whether L-Arg supplementation could alleviate adverse exposure. Data from 107 included final analysis. Short-term associated significantly decreased cGMP MPO levels, increased STDE risk, modifying O3-STDE associations. Participants lower levels or higher demonstrated vulnerability harmful inferior leads. attenuated hs-CRP. Plasma (cGMP MPO) are likely involved potential pathways connecting cardiac effects. Supplementation showed mitigate inverse inflammation.

Language: Английский

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TCF7L2 as a target of peripheral artery disease in patients with type 2 diabetes: A 2-sample Mendelian randomization and bioinformatics study

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41431 - e41431

Published: Feb. 14, 2025

This study examines the causal relationship between type 2 diabetes (T2D) and peripheral artery disease (PAD) their potential mechanisms based on analysis of Gene Expression Omnibus database 2-sample Mendelian randomization (MR). The first part involved a MR comprehensive meta-analysis. Differences in results were assessed using inverse-variance weighting. Heterogeneity was examined Cochrane Q statistical test. leave-one-out method applied for sensitivity analysis. horizontal pleiotropic effect MR-Egger intercept technique. second differential gene weighted coexpression network Subsequently, we overlapped consolidated from parts to identify key genes them. suggested statistically significant correlation incidence PAD T2D (odds ratio: 1.22, 95% confidence interval: 1.13–1.32, P = 3.74e−07). We anticipated pivotal role TCF7L2 T2D. significantly associated with risk. Simultaneously, deepened our understanding underlying both diseases, proposing as promising target.

Language: Английский

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Interacting and joint effects of frailty and inflammation on cardiovascular disease risk and the mediating role of inflammation in middle-aged and elderly populations

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 20, 2025

Frailty and inflammation may increase the risk of cardiovascular disease (CVD), but their interacting joint effects on CVDs remain unclear. To explore interaction frailty role in relationship between to provide better understanding underlying pathogenesis CVD. A total 220,608 initially CVD-free participants were recruited from UK Biobank database categorized into non-frailty, pre-frailty, groups based Fried's criteria. The also grouped according low-grade (INFLA) score its components: neutrophil-lymphocyte ratio, C-reactive protein, white blood cell count, platelet count. Cox proportional hazards models with hazard ratios (HRs) 95% confidence intervals (CIs) used assess phenotypes CVD risk. Mediation analysis was quantify association CVDs. potential interactions terms evaluated using additive multiplicative scales. During a median follow-up 13.3 years, 48,978 developed After adjusting for various confounders, pre-frailty had higher than those non-frailty (HRs: 1.20 (95% CI: 1.18-1.23) 1.80 1.69-1.91), respectively). observed among moderate high INFLA scores low 1.09 1.07-1.12) 1.27 1.24-1.30), components limited mediating Significant scale not scale. Inflammation amplify harmful effect incidence Improving alone might substantially reduce CVDs, effectively controlling help negative health.

Language: Английский

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A framework for detecting causal effects of risk factors at an individual level based on principles of Mendelian randomisation: applications to modelling individualised effects of lipids on coronary artery disease

EBioMedicine, Journal Year: 2025, Volume and Issue: 113, P. 105616 - 105616

Published: Feb. 28, 2025

Language: Английский

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Frailty, high-sensitivity C-reactive protein and cardiovascular disease: a nationwide prospective cohort study

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 28, 2025

Abstract Background This study aimed to investigate the complex associations of frailty and high-sensitivity C-reactive protein (hsCRP) with cardiovascular disease (CVD) through a nationwide prospective cohort, while also assessing mediating associations. Methods According critical criteria, total 5239 participants from China Health Retirement Longitudinal Study (CHARLS) in 2011 were ultimately enrolled this study. Frailty was evaluated by index 40 items, CVD defined as presence physician-diagnosed heart and/or stroke. A restricted cubic spline model, receiver operating characteristic curves, adjusted Cox proportional hazards regression, interaction analyses mediation performed for association exploration. Results During maximum follow-up 7.0 years, 1204 (23.67%) people developed CVD. Both elevated hsCRP significantly associated incidence. Compared healthy status low (< 1.015 mg/L), those had highest risk (adjusted HR, 2.97; 95% CI 2.29–3.84), 2.93; 2.16–3.96), stroke 4.26; 2.81–6.44), which still robust subgroup analysis. Moreover, mediated 19.60% between Conclusions Combined assessment levels helps better stratify individual could partly mediate

Language: Английский

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