Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health

Current Pharmacology Reports, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 5, 2024

Abstract Purpose of Review Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2–related 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin demonstrated significant antioxidant anti-inflammatory properties, making them promising agents chemoprevention. This review examines the pharmacokinetic (PK) pharmacodynamic (PD) profiles these with a focus on NRF2-mediated effects Recent Findings Preclinical studies highlighted to modulate oxidative stress inflammation, key drivers carcinogenesis. We explore complexity PK/PD influenced by factors bioavailability, metabolism, drug interactions. While most follow two compartmental PK, anti-oxidant indirect response (IDR) model. Furthermore, we discuss application physiologically based (PBPK) modeling simulate behavior humans, providing insights clinical translation. Summary The integration PK-PD analysis into development phytochemical-based therapies offers pathway optimize dosing strategies, enhance therapeutic efficacy, improve safety. underscores importance part interception particularly early stages development, where they may offer natural, less toxic alternative conventional therapies. Graphical

Language: Английский

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Developing High-Coloring Natural Systems Using Double Emulsions with Daucus carota L. Extract to Meet High-Performance Requirements

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4147 - 4147

Published: Dec. 21, 2024

Daucus carota L. extract is attracting interest as a natural colorant alternative. However, the presence of anthocyanins (ACNs), which are sensitive to pH changes, limits its application. To tackle this issue, water-in-oil-in-water (W1/O/W2) double emulsions emerging innovative solutions. Nevertheless, problem reaching robust systems for industrial use still needs be overcome. One important target reach high coloring power, minimizing impact on final product. In context, effect concentration and volume primary emulsion, two routes increase color attributes stability, an feature marketable product, was studied. The optimal experimental design conducted solutions, whether through heightened or emulsion volume: 41/59 (W1/O)/W2 ratio with 11 wt.% colorant, 48/52 6 respectively. A subsequent assessment physical stability over 30 days pointed out solution lower (6 wt.%) one better performance (L*: 44.11 ± 0.03, a*: 25.79 0.01, D4;3: 9.62 0.1 µm, CI: 14.55 0.99%), also permeability outer aqueous phase. Overall, these optimized offer versatile solutions suitable various applications, such food matrices functional cosmetics.

Language: Английский

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CTRP3/AMPK pathway plays a key role in the anti-hypertrophic effects of cyanidin-3-O-glucoside by inhibiting the inflammatory response

Advances in Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 33(8), P. 831 - 841

Published: Nov. 14, 2023

Cardiac hypertrophy can be a pathological process that impairs heart function. Anthocyanins are well-characterized type of natural antioxidant, and recent studies have shown this compound has potential cardioprotective effects against different disorders, such as cardiac hypertrophy.

Language: Английский

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