Kavain Hydroxylation in Kava Metabolism: Computational Analysis DOI Open Access

Youlin Feng

Journal of Student Research, Journal Year: 2023, Volume and Issue: 12(4)

Published: Nov. 30, 2023

Kava, a non-alcoholic beverage derived from the Piper methysticum plant, commonly also known as has prominent role in cultures of Oceania due to its calming and soothing effects. These psychoactive properties have sparked interest beyond scientific community, who see potential for medicinal applications. However, alongside these beneficial effects, consumption Kava been linked hepatotoxicity, raising safety concerns. Understanding cause this hepatotoxicity requires detailed exploration Kava's metabolic processes, specifically those involving kavain, primary constituent. Recent studies found hydroxylation kavain 12-hydroxykavain key step pathway. Yet, precise mechanism conversion intermediates involved remain poorly understood. To address knowledge gap, our study employed Spartan, computational chemistry software, model process. We analyzed stability chemical proposed reaction intermediates, providing view critical phase metabolism. Our analysis reveals that three five appear stable, suggesting they may play significant roles This finding enabled us narrow down possible pathways hydroxylation. Having better understanding metabolism could guide development safer, more effective Kava-based products, balancing therapeutic with reduced risk profile.

Language: Английский

Global burden of cancer and associated risk factors in 204 countries and territories, 1980–2021: a systematic analysis for the GBD 2021 DOI Creative Commons
Zeng‐Hong Wu,

Fangnan Xia,

Rong Lin

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 29, 2024

Cancer is the second most common cause of death globally. Therefore, it imperative to investigate cancer incidence, mortality rates, and disability-adjusted life years (DALYs) enhance preventive measures healthcare resource allocation. This study aimed assess burden associated risk factors in 204 countries territories between 1980 2021. We selected data on incidence rates from global disease (GBD) tool for 1990 2021 estimated age-standardized (ASIR) deaths (ASDR) 34 types categorized as level 3 causes based GBD hierarchy. In 2021, accounted 14.57% (95% uncertainty interval: 13.65–15.28) total 8.8% (7.99–9.67) DALYs both sexes ASIR ASDR were 790.33 (694.43–893.01) 116.49 (107.28–124.69), respectively. Additionally, females exhibited higher than males (923.44 versus 673.09), while (145.69 93.60). indicates that policymakers should focus importance gender equality healthcare. Non-melanoma skin highest (74.10) sexes, digestive cancers 39.29% all cancer-related deaths, Asia heaviest burden. females, breast (46.40) (14.55). males, tracheal, bronchial, lung (37.85) (34.32), highlighting urgent need targeted tobacco control measures. Different various exhibit unique characteristics. formulate specific prevention strategies reflect their country. Tobacco was primary 2 factor males. It 29.32% (25.32–33.14) DALYs. Dietary risks, alcohol consumption, air pollution 5.89% (2.01–10.73), 5.48% (4.83–6.11), 4.30% (2.77–5.95) male DALYs, prioritize smoking regulation other carcinogenic risks. a significant public health concern Understanding etiologies different essential developing effective interventions.

Language: Английский

Citations

19
Role of cuproptosis in understanding diseases DOI Open Access

Shihan Cao,

Qian Wang,

Zhenzhen Sun

et al.

Human Cell, Journal Year: 2023, Volume and Issue: 36(4), P. 1244 - 1252

Published: May 8, 2023

Language: Английский

Citations

26
Combination of the cuproptosis inducer disulfiram and anti‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway DOI Creative Commons
Pengfei Li, Qi Sun,

Shuping Bai

et al.

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 53(2)

Published: Dec. 28, 2023

Disulfiram (DSF) is used to treat non‑small cell lung cancer (NSCLC). DSF significantly increases expression of programmed death‑ligand 1 (PD‑L1), which may enhance immunosuppression and immune escape tumors. Therefore, the present study aimed investigate role combined treatment anti‑PD‑L1 in NSCLC resistance. The viability apoptosis A549 cells were detected by Cell Counting Kit‑8 assay flow cytometry, respectively. levels ATPase copper‑transporting β (ATP7B) PD‑L1 reverse transcription‑quantitative PCR western blot analysis. reactive oxygen species (ROS), malondialdehyde (MDA) superoxide dismutase (SOD) respective kits. cuproptosis‑associated proteins ferredoxin‑1 (FDX1), ATP7B, solute carrier family 31 member (SLC31A1), succinate dehydrogenase B (SDHB), hypoxia inducible factor (HIF)‑1A analyzed blotting cells. inhibited promoted ATP7B at both mRNA protein cisplatin (DPP)‑treated was increased following treatment. JQ‑1 (a inhibitor) suppressed DPP‑treated pretreated with DSF. PD‑L1. combination ROS MDA, as well FDX1 SLC31A1; however, decreased SOD, SDHB, PD‑L1, HIF‑1A. PX478 (an HIF‑1 acted inhibitory effects on induction upregulated while it downregulated SOD DSF‑treated SLC31A1, HIF‑1A In conclusion, enhanced effect cuproptosis inhibition viability.

Language: Английский

Citations

10
Herb-Drug Interactions DOI
James Oluwagbamigbe Fajemiroye, Ânderson Luiz-Ferreira,

Roberto Saavedra-Rodríguez

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Potential of Ginger Oil to Prevent 4‐(Methylnitrosamino)‐1‐(3‐Pyridyl)‐1‐Butanone‐Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition DOI
Yan Ding, Lei Zhang, Wenli Zhao

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

ABSTRACT Lung cancer remains the leading cause of cancer‐related mortality worldwide, with tobacco carcinogens such as 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) playing a central role in its pathogenesis. Chemoprevention through dietary or natural compounds offers promising strategy to mitigate risk. Published studies have indicated that ginger oil (GIO), bioactive extract from ginger, possesses various bioactivities, suggesting potential for chemopreventive. In this study, we aimed investigate lung chemopreventive GIO. An NNK‐induced model A/J mice was utilized evaluate preventive effect GIO against cancer. Additionally, mechanisms by which might prevent were assessed using molecular biology techniques combined multi‐omics. The results demonstrated decreased number tumors lungs mice. Mechanistically, exerts effects modulating both TLR4/NF‐κB and PPARγ/NF‐κB signaling axes, thereby suppressing downstream pro‐inflammatory mediators. Furthermore, modulates gut microbiota composition metabolites. Critically, efficacy carcinogenesis is partially dependent on microbiota‐mediated regulation. Overall, these findings underscore nutritional value diet‐derived agent caused carcinogens.

Language: Английский

Citations

0
NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation, migration, invasion and cell cycle <i>in vitro</i> DOI Open Access

PEILING WU,

LIFANG ZHAO,

Hongyan Zhang

et al.

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 32(9), P. 1439 - 1452

Published: Jan. 1, 2024

The pro-oncogenic effects of NCAPD2 have been extensively studied across various tumor types; however, its precise role within the context lung adenocarcinoma (LUAD) remains elusive.This study aims to elucidate biological functions in LUAD and unravel underlying mechanistic pathways.Utilizing bioinformatics methodologies, we explored differential expression between normal samples, along with correlations clinical-pathological characteristics, survival prognosis, immune infiltration.In TCGA-LUAD dataset, samples demonstrated significantly elevated levels compared (p < 0.001).Clinically, higher was notably associated advanced T, N, M stages, pathologic stage, gender, smoking status, diminished overall (OS).Moreover, differentially expressed genes (DEGs) were predominantly enriched pathways related cell division.Immune infiltration analysis revealed that linked memory B cells, naïve CD4+ T activated M1 macrophages.In vitro experiments silencing suppressed proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), cycle progression.In summary, may represent a promising prognostic biomarker novel therapeutic target for LUAD.

Language: Английский

Citations

2
Risk factors for the development of lung cancer around the world: a review DOI Creative Commons

Hervé Agonsanou,

Ricardo G. Figueiredo,

Maurice Bergeron

et al.

Exploration of Medicine, Journal Year: 2023, Volume and Issue: unknown, P. 1168 - 1188

Published: Dec. 29, 2023

According to recent data reported, it is noted that lung cancer the leading cause of death internationally followed by cardiovascular diseases and diabetes. This disease observed in both women men related lifestyle habits. Several causes are reported be at origin cancer, especially smoking. It important note majority cancers develop bronchi, say level upper airways which lead lungs, does not however make possible rule out risk factors come under environmental pollution since man breathes air quality environment every day for his breathing. review literature has made draw up a state knowledge order understand increase cancer. More specifically, this work will raise awareness field fight against particular

Language: Английский

Citations

1
Naturally based mystic drugs DOI
Francesc A. Esteve‐Turrillas

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Clinicopathological characteristics correlated with programmed cell death-ligand 1 expression in advanced lung adenocarcinoma DOI Open Access

Hengxing Gao,

Xuexue Zou,

Jing Wang

et al.

Journal of Thoracic Disease, Journal Year: 2023, Volume and Issue: 15(10), P. 5307 - 5318

Published: Oct. 1, 2023

Background: Recent studies have shown that immune checkpoint inhibitors (ICIs) targeting programmed cell death-ligand 1 (PD-L1) potential benefits in patients with non-small lung cancer (NSCLC) subgroups, while the clinicopathological characteristics associated PD-L1 expression not been well established. The purpose of this study was to detect level tumor tissues advanced adenocarcinoma (ADC) and analyze its possible relationship characteristics, so as identify predictors expression. Methods: This retrospective conducted by analyzing imaging hospitalized ADC available data admitted respiratory department our hospital. fresh-frozen tissue samples 136 analyzed immunohistochemistry. were divided into positive negative groups based on a cut-off 1% level. Subsequently, significant correlation between levels features evaluated. predictive performance evaluated optimal values identified plotting receiver operating characteristic (ROC) curve. Results: related sex, clinical stage, serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE), white blood (WBC), (T) metastasis (M) stage. Multivariate logistic regression analysis showed CEA, NSE, T WBC independent patients. ROC curve suggested model combining CEA NSE [area under (AUC) =0.815] could better predict PD-L1. for identifying ≤13.38 ng/mL ≤42.35 ng/mL, sensitivity specificity 85.4% 55.6%, 92.7% 32.1%, respectively. Conclusions: Some commonly used are histological can be indicators ADC, evaluate efficacy ICIs before treatment.

Language: Английский

Citations

0
Kavain Hydroxylation in Kava Metabolism: Computational Analysis DOI Open Access

Youlin Feng

Journal of Student Research, Journal Year: 2023, Volume and Issue: 12(4)

Published: Nov. 30, 2023

Kava, a non-alcoholic beverage derived from the Piper methysticum plant, commonly also known as has prominent role in cultures of Oceania due to its calming and soothing effects. These psychoactive properties have sparked interest beyond scientific community, who see potential for medicinal applications. However, alongside these beneficial effects, consumption Kava been linked hepatotoxicity, raising safety concerns. Understanding cause this hepatotoxicity requires detailed exploration Kava's metabolic processes, specifically those involving kavain, primary constituent. Recent studies found hydroxylation kavain 12-hydroxykavain key step pathway. Yet, precise mechanism conversion intermediates involved remain poorly understood. To address knowledge gap, our study employed Spartan, computational chemistry software, model process. We analyzed stability chemical proposed reaction intermediates, providing view critical phase metabolism. Our analysis reveals that three five appear stable, suggesting they may play significant roles This finding enabled us narrow down possible pathways hydroxylation. Having better understanding metabolism could guide development safer, more effective Kava-based products, balancing therapeutic with reduced risk profile.

Language: Английский

Citations

0