Therapeutic Potential of Dimethyl Fumarate for the Treatment of High-Fat/High-Sucrose Diet-Induced Obesity DOI Creative Commons
Helber da Maia Valença,

E Moţa,

A. Silva

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1496 - 1496

Published: Dec. 8, 2024

Obesity is characterized by an imbalance between energy intake and expenditure that triggers abnormal growth of adipose tissues. Dimethyl fumarate (DMF) its primary active metabolite, monomethyl (MMF), are Nrf2 activators have been recognized as strategic antioxidants. This study aimed to evaluate the potential MMF DMF interfere with adipogenesis obesity, identify molecular mechanisms involved. The 3T3-L1 preadipocytes were incubated differentiation medium (MIX) simultaneously treated different concentrations MMF. In addition, male C57BL/6 mice fed a standard diet or high-fat/high-sucrose (HFHSD) for 16 weeks, during last 4 which, they received oral treatment. Exposure prevented development MIX-induced reducing expression transcription factors drive adipocyte decreasing triglyceride levels. various antioxidant anti-inflammatory effects observed after treatment evidenced modulation factor activities reduction in reactive oxygen species, adipokine, proinflammatory cytokine resistin vivo reduced calorie intake, body weight, visceral subcutaneous fat mass HFHSD mice. Furthermore, administration led better glycemic response well lower leptin adiponectin plasma levels these animals. Our data demonstrate metabolite prevent key features diet-induced obesity. Considering already commercial drug used treat psoriasis multiple sclerosis, pharmacological application obesity related metabolic disorders holds promise.

Language: Английский

Activation of SIRT1 by SRT1720 Alleviates Dyslipidemia, Improves Insulin Sensitivity and Exhibits Liver-Protective Effects in Diabetic Rats on a High-Fat Diet: New Insights into the SIRT1/Nrf2/NFκB Signaling Pathway DOI Creative Commons
Elsayed A. Elmorsy, Hossam A. Elsisi, Abdullah S. Alkhamiss

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 206, P. 107002 - 107002

Published: Jan. 6, 2025

Insulin resistance and diabetes are associated with non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) conditions, which distinguished by metabolic dysfunction, oxidative stress inflammation. Sirtuin 1 (SIRT1), a NAD

Language: Английский

Citations

4
Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications DOI
Daniel Ejim Uti, Item Justin Atangwho,

Wilson Achu Omang

et al.

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Jan. 1, 2025

Language: Английский

Citations

3
Assessing the therapeutic potential and safety of traditional anti-obesity herbal blends in Palestine DOI Creative Commons
Mohammed Hawash, Nidal Jaradat,

Nihal Ayman Salhi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 22, 2024

Abstract The use of traditional herbal remedies has been a common practice for centuries across different cultures to treat various ailments. In Palestine, medicines are widely used, but their efficacy and safety have not thoroughly investigated. Therefore, the purpose this study was assess biological activity toxicity two blends often used obesity in West Bank region Palestine. Two with total eight plants were chosen based on historic availability. plant aqueous extracts evaluated antioxidant, anti-fibrotic, anti-obesity, anti-diabetic, cytotoxic activities. results showed that these potent antifibrotic, anticancer While activities α-amylase lipase enzymes (main targets) moderate our Herbal Blend 2 more than 1 all investigated targets. significant as an IC 50 values 68.16 ± 2.45, 33.97 1.14, 52.53 0.78 µg/mL against DPPH, LX-2, MCF-7 cell lines, respectively. it is 243.73 1.57 1358.39 2.04 µg/mL, However, anti-cancer can be challenging due effects body. We urge individuals exercise caution when using natural seek medical advice before incorporating them into health regimens. This provides valuable insight potential benefits emphasizes importance responsible usage.

Language: Английский

Citations

9
Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators DOI Creative Commons
Lin Liu, Yanbo Zhao, Zeneng Cheng

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 29, 2025

Language: Английский

Citations

1
Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis DOI Creative Commons

Xuyun Xia,

Qin Zhang, Xia Fang

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 24, 2025

Abstract Background The epidemic of metabolic dysfunction‐associated fatty liver disease linked to excessive high‐fat diet (HFD) consumption has sparked widespread public concern. Nuclear factor erythroid 2‐related 2 (NRF2) been reported improve glucose/lipid metabolism, lipid degeneration and alleviate HFD‐induced inflammation. However, its pathways mechanisms action are not fully understood. Methods To confirm the effect NRF2 on metabolism in liver, Nrf2‐/‐ mice as well liver‐specific Nrf2 knockout mice, AAV‐TBG‐Nrf2 were employed. hyperinsulinemic‐euglycemic clamp was utilized determine glucose metabolism. elucidate pyroptosis, we performed western blots, immunofluorescence, quantitative real‐time PCR, Flow cytometry experiments. Finally, chromatin immunoprecipitation‐seq dual‐luciferase reporter assay used underscore transcriptional regulatory Gsdmd. Results We found that overexpression inhibited expression inflammatory cytokines pyroptosis markers, including cle‐Caspase1, NLRP3 N‐terminus gasdermin D (N‐GSDMD) both vivo vitro, while deficiency opposite. Specifically, with up‐regulated, GSDMD decreased Gsdmd partially reversed pro‐inflammatory phenotype. Mechanistically, demonstrate binds promoter at −2110 ‐ 1130 bp site, inhibiting thereby improving steatosis. Conclusion Our data indicate is an effective inhibitor a multi‐target treatment obesity‐related diseases. Key points MAFLD associated increased hepatocytes expression. alleviates by suppressing pyroptosis. directly inhibits regulate Targeting NRF2–pyroptosis (GSDMD) axis offers potential therapeutic strategy for MAFLD.

Language: Английский

Citations

1
Thioredoxin-interacting protein TXNIP as a promising diagnostic marker for metabolic-associated fatty liver disease in patients with type 2 diabetes DOI Creative Commons
A. R. Meltonian,

M. Yu. Laevskaya,

Yu. N. Savchenkov

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2025, Volume and Issue: 23, P. 137 - 143

Published: Jan. 22, 2025

Introduction . Metabolic-associated fatty liver disease (MAFLD) is a common that has pathogenesis-based relationship with type 2 diabetes (T2D). Aim. To determine the levels of TXNIP protein in patients MAFLD and T2D who were on metformin monotherapy, to compare these findings MRI liver, assess changes six months after starting treatment glucagon-like peptide-1 receptor agonists (GLP-1RA) sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Materials methods The study included 49 (34 female 15 male) MAFLD, aged 55 ± 8 years, followed up at outpatient clinic Almazov National Medical Research Centre (St. Petersburg) from January 2023 March 2024. eligibility criteria BMI values 25–40 kg/m² glycated hemoglobin level not exceeding 9.5%. Results. showed serum positively correlated severity assessed based findings. Furthermore, significantly decreased as result therapy GLP-1RAs SGLT-2 Conclusion. These correlation data suggest could be used promising diagnostic marker T2D, both stage evaluation when considering outcomes ongoing therapy.

Language: Английский

Citations

0
Crosstalk between microRNA and inflammation; critical regulator of diabetes DOI

Amr Ali Mohamed Abdelgawwad El-Sehrawy,

Mohammed H. Mohammed,

Omar Dheyauldeen Salahdin

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 447(1), P. 114507 - 114507

Published: March 7, 2025

Language: Английский

Citations

0
Polysorbate 80 in Diabetes and Non-Alcoholic Fatty Liver Disease: Decoding Mechanisms of Hepatic Insulin Resistance and Its Cellular, Molecular, and Epigenetic Targets DOI
Zeshan Ali,

Ishrat Khan,

Usman Waheed

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: April 11, 2025

Language: Английский

Citations

0
Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(3)

Published: March 1, 2025

Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis insulin or impaired function. Throughout history, several civilizations have used traditional medicinal plants treat and control diabetes. This paper offers thorough review, date, antidiabetic natural compounds origin, specifically highlighting their reported modes mechanisms action therapeutic possibilities, with view fast-tracking possibility transition pharmaceutical products for human use. Phytochemicals such as flavonoids, alkaloids, terpenoids, glycosides notable effects. They been shown via many processes, including boosting secretion, improving sensitivity, blocking absorption \gastrointestinal-tract, regulating carbohydrate metabolism. Unlike earlier reviews, this current one, addition chemistry proposed action, also x-rays effectiveness safety these chemicals combining evidences from laboratory research, animal experiments, clinical trials. Several substances, Demethoxycurcumin, Trigonelline, Ginsenosides, progressed trials, while others like Allicin Polypeptide-p at bedside. Bisdemethoxycurcumin, Vicine, Gymnemosides, are now preclinical trial phase, suggesting that research still ongoing there promise future application. The review highlights evolution diabetes management, potential improve treatment. It suggests incorporating plant-derived into treatments, reducing dependence on drugs adverse

Language: Английский

Citations

0
Age-specific associations of RBC folate and several serum folate forms with obesity risk: NHANES 2011–2018 DOI Creative Commons
Meng Wang, Ziyi Tong, C Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

This study aims to explore the associations between RBC folate, several serum folate forms [serum total 5-methyltetrahydrofolate (5-mTHF), and unmetabolized folic acid (UMFA)], obesity risk in middle-aged older populations. Data from NHANES (2011-2018) included 11,615 participants. Generalized linear models (GLMs) were applied investigate of various with after multivariable adjustment. Potential effect modifications examined through stratified analyses multiplicative interaction testing. Among sample, middle-aged, participants, 4578 (39.4%), 3613 (40.0%), 965 (37.2%) obese, respectively. A positive association was observed, highest risks consistently found fourth quartile (≥ 1,430 nmol/L) for adults (OR = 1.104, 95% CI: 1.045-1.166) participants 1.157, 1.036-1.293). significant negative levels an OR 0.804 (95% 0.773-0.835) 54.2 nmol/L). Similarly, 5-mTHF negatively associated risk, 0.800 0.772-0.830) 51.2 Most importantly, UMFA 1.06 had a higher (OR, 1.056; 1.004-1.110) compared those lower levels, but this not or Significant relationships exist risk. Additionally, low high increased highlighting importance monitoring concentrations guiding future clinical trials on supplementation.

Language: Английский

Citations

0