Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer DOI Creative Commons
Desh Deepak Singh, Shafiul Haque, Youngsun Kim

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Triple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of affecting women globally. Regrettably, treatment options for TNBC remain limited due to its clinical complexity. However, immunotherapy has emerged a promising avenue, showing success in developing effective therapies advanced cases improving patient outcomes. Improving treatments involves reducing side effects, minimizing systemic toxicity, enhancing efficacy. Unlike traditional immunotherapy, engineered nonmaterial's can precisely target TNBC, facilitating immune cell access, antigen presentation, triggering lasting responses. Nanocarriers with enhanced sensitivity specificity, specific cellular absorption, low toxicity are gaining attention. Nanotechnology-driven immunoengineering strategies focus on targeted delivery systems using multifunctional molecules precise tracking, diagnosis, therapy TNBC. This study delves into TNBC's tumour microenvironment (TME) remodeling, therapeutic resistance, nanotechnology.

Language: Английский

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective DOI Creative Commons
Yifan Liu,

Renjie Pan,

Yuzhen Ouyang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

40
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications DOI
Abhishek Satheesan, Janardanan Kumar,

K.V. Leela

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2753 - 2779

Published: Aug. 19, 2024

Language: Английский

Citations

7
Podocyte programmed cell death in diabetic kidney disease: Molecular mechanisms and therapeutic prospects DOI Open Access

Haoyu Yang,

Jun Sun,

Aru Sun

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117140 - 117140

Published: July 16, 2024

Language: Английский

Citations

5
Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions DOI Creative Commons
Huimin Wang, Qian Ding, Ying Chen

et al.

Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Unveiling the Therapeutic Role of Penfluridol and BMS-754807: NUDT5 Inhibition in Breast Cancer DOI Creative Commons

Majed S. AlFayi,

Mοhd Saeed, Irfan Ahmad

et al.

Chemical Physics Impact, Journal Year: 2025, Volume and Issue: unknown, P. 100871 - 100871

Published: April 1, 2025

Language: Английский

Citations

0
Neuregulin 4 Attenuates Podocyte Injury and Proteinuria in Part by Activating AMPK/mTOR‐Mediated Autophagy in Mice DOI Open Access

Juntian Deng,

Yang Qian-Sheng,

Wanyu Zhu

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 125(10)

Published: Aug. 2, 2024

ABSTRACT In this study, we investigate the effect of neuregulin 4 (NRG4) on podocyte damage in a mouse model diabetic nephropathy (DN) and elucidate underlying molecular mechanisms. vivo experiments were conducted using C57BL/6 DN to determine NRG4 proteinuria injury, vitro performed with conditionally immortalized podocytes treated high glucose assess protective effects injury. Autophagy‐related protein levels related signaling pathways evaluated both vitro. The involvement adenosine monophosphate‐activated kinase (AMPK)/mammalian target rapamycin (mTOR) pathway was detected chloroquine or AMPK inhibitors. results showed that AMPK/mTOR involved roles against glucose‐mediated Also, significantly decreased albuminuria mice. PAS staining indicated mitigated glomerular volume mesangium expansion Consistently, western blot RT‐PCR analyses confirmed expression pro‐fibrotic molecules glomeruli immunofluorescence retained podocin nephrin, whereas transmission electron microscopy revealed alleviated mice, apoptosis increased nephrin podocin, while decreasing desmin HIF1α. Overall, improved albuminuria, glomerulosclerosis, glomerulomegaly, hypoxia inhibited HG‐induced injury apoptosis. Furthermore, autophagy but reactivated following intervention. intervention found partially activate via pathway. Consequently, when suppressed inhibited, beneficial diminished. These indicate attenuates by promoting kidneys part, activating

Language: Английский

Citations

3
Special Issue IJMS—Molecular Mechanisms of Diabetic Kidney Disease DOI Open Access
Ligia Petrică

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 790 - 790

Published: Jan. 8, 2024

Diabetic kidney disease (DKD), as a major microvascular complication of both type 1 and 2 diabetes mellitus (DM), accounts for over 40% patients that reach end-stage renal are referred to replacement therapies [...]

Language: Английский

Citations

1
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets DOI Open Access

Suye Zhong,

Na Wang, Chun Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9035 - 9035

Published: Aug. 20, 2024

Cell deaths maintain the normal function of tissues and organs. In pathological conditions, abnormal activation or disruption cell death often leads to pathophysiological effects. Diabetic kidney disease (DKD), a significant microvascular complication diabetes, is linked high mortality morbidity rates, imposing substantial burden on global healthcare systems economies. Loss detachment podocytes are key changes in progression DKD. This review explores potential mechanisms apoptosis, necrosis, autophagy, pyroptosis, ferroptosis, cuproptosis, podoptosis podocytes, focusing how different modes contribute It recognizes limitations current research presents latest basic clinical studies targeting podocyte pathways Lastly, it focuses future treat DKD, with intention inspiring further development therapeutic strategies.

Language: Английский

Citations

1
Features of Opioid Use Disorder: Interlinking Transcriptomics, Epigenetics, and Postmortem Studies Highlight Opioid-Induced Neurovascular Alterations DOI
Consuelo Walss‐Bass

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 1, 2024

Language: Английский

Citations

1
Identification and validation of disulfidptosis-related gene signatures and their subtype in diabetic nephropathy DOI Creative Commons
Danping Xu,

Chonghao Jiang,

Yonggui Xiao

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 6, 2023

Background: Diabetic nephropathy (DN) is the most common complication of diabetes, and its pathogenesis complex involving a variety programmed cell death, inflammatory responses, autophagy mechanisms. Disulfidptosis newly discovered mechanism death. There are little studies about role disulfidptosis on DN. Methods: First, we obtained data required for this study from GeneCards database, Nephroseq v5 GEO database. Through differential analysis, disulfidptosis-related genes. At same time, through WGCNA key module genes in DN patients. The intersecting were further screened by Lasso as well SVM-RFE. By results two, ended up with gene diabetic nephropathy. diagnostic performance expression verified GSE30528, GSE30529, GSE96804, datasets. Using clinical information investigated correlation between estimated glomerular filtration rate (eGFR) serum creatinine content. Next, constructed nomogram analyzed immune microenvironment patients identification subtypes facilitates individualized treatment Results: We 91 39 Taking intersection preliminarily 20 characteristic found that these positively correlated each other. Further screening SVM-RFE algorithms identified CXCL6, CD48, C1QB, COL6A3 Clinical analysis levels closely related to eGFR. Immune infiltration higher samples than normal samples. Conclusion: validated 4 may be promote onset eGFR infiltrated kidney tissue.

Language: Английский

Citations

3