Gut Microbiota and Mitochondria: Health and Pathophysiological Aspects of Long COVID
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17198 - 17198
Published: Dec. 6, 2023
The
current
understanding
of
long
COVID
(LC)
is
still
limited.
This
review
highlights
key
findings
regarding
the
role
gut
microbiota,
mitochondria,
and
main
pathophysiological
aspects
LC
revealed
by
clinical
studies,
related
to
complex
interplay
between
infection,
intestinal
dysbiosis,
dysfunctional
systemic
inflammation
generated
in
a
vicious
circle,
reflecting
molecular
cellular
processes
from
"leaky
gut"
electron
transport
chain
(ETC)"
into
quantum
leap.
heterogeneity
has
hindered
progress
deciphering
all
mechanisms,
therefore,
approach
must
be
multidisciplinary,
with
special
focus
not
only
on
symptomatic
management
but
also
addressing
underlying
health
problems
patients.
It
imperative
further
assess
validate
effects
COVID-19
microbiome
their
relationship
infections
other
viral
agents
or
pathogens.
Further
studies
are
needed
better
understand
expand
interdisciplinary
points
view
that
required
accurately
diagnose
effectively
treat
this
heterogeneous
condition.
Given
ability
SARS-CoV-2
induce
autoimmunity
susceptible
patients,
they
should
monitored
for
symptoms
autoimmune
disease
after
contracting
infection.
One
question
remains
open,
namely,
whether
various
vaccines
developed
end
pandemic
will
autoimmunity.
Recent
data
highlighted
have
persistence
mitochondria
organs
such
as
heart
and,
lesser
extent,
kidneys,
liver,
lymph
nodes,
organism
been
able
clear
virus
lungs,
could
an
explanation
LC.
Language: Английский
Microbiome and the COVID-19 pandemic
Elsevier eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 287 - 348
Published: Jan. 1, 2024
Language: Английский
Longitudinal Fecal Microbiota Profiles in A Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(11), P. 953 - 953
Published: Oct. 31, 2024
Adolescents
most
often
experience
mild
acute
COVID-19,
but
may
still
face
fatigue
and
persistent
symptoms
such
as
post-COVID-19
condition
(PCC)
post-infective
syndrome
(PIFS).
We
explored
the
fecal
microbiota
of
SARS-CoV-2
positive
negative
non-hospitalized
adolescents
young
adults
(12-25
years
age)
in
"Long-Term
Effects
COVID-19
Adolescents"
(LoTECA)
project,
a
longitudinal
observational
cohort
study.
With
targeted
qPCR
approach,
quantities
100
bacterial
taxa
were
measured
at
baseline
(early
convalescent
stage)
145
SARS-CoV-2-positive
32
participants
after
six
months
107
19
participants.
Results:
Language: Английский