Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models DOI Creative Commons
Alina Ioana Ardelean,

Sorin Marian Mârza,

Raluca Marica

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1097 - 1097

Published: Aug. 30, 2024

Repairing or reconstructing significant bone defects is typically challenging. In the present study, two composite cements were used as scaffolds in a sub-critical femoral defect rats. A control group and experimental batches to compare outcomes. This research aimed investigate osteogenic potential toxicological tolerance of bioproducts through histopathology computed tomography imaging analysis at 14, 28, 56, 90 days post-implantation. The biomaterials investigation consisted 65% bioactive salinized inorganic filler 25% weight organic matrix. part biomaterial was composed Bis-GMA (bisphenol A-glycidyl methacrylate), UDMA (urethane dimethacrylate), HEMA (2-Hydroxyethyl TEGDMA (triethylene glycol while silica, barium glass, hydroxyapatite, fluor aluminosilicate glass. first findings this are encouraging, revealing that there slight difference between groups treated with biomaterials, but it might be an effective approach for managing abnormalities. Material C1 exhibited faster healing time compared material C2, where fractures occurred some individuals. It unclear if caused by presence C2 whether additional variables blame. By end research, mice appeared tolerate without exhibiting any inflammatory rejection responses.

Language: Английский

Progress in the Preparation and Applications of Microcapsules for Protective Coatings Against Corrosion DOI Open Access

Shupei Liu,

J. Li,

Zhang Yan-chi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1473 - 1473

Published: Feb. 10, 2025

The annual economic loss caused by corrosion accounts for about 2%~4% of GDP, which exceeds the sum losses fires, floods, droughts, typhoons, and other disasters. Coating is one most effective methods to delay metal corrosion. With development technology intersection disciplines, functional microcapsules have been applied anticorrosive coatings, but are still being updated. To understand application progress in future trend analyzed. preparation methods, physical chemical properties, characteristics, trends organic, inorganic, organic-inorganic hybrid described, respectively, from perspective material molecular characteristics. Simultaneously, influence different materials on properties organic coatings proved examples. In addition, research status microcapsule composite coating introduced detail. Finally, great advantages modified based natural inorganic improving utilization efficiency loaded active substances prolonging life foreseen.

Language: Английский

Citations

0

Assessing Biocompatibility of Composite Cements by Peri/Intramuscular and Subcutaneous Implantation in Rats DOI Creative Commons
Alina Ioana Ardelean,

Sorin Marian Mârza,

Andrada Negoescu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1718 - 1718

Published: Aug. 1, 2024

This study's goal was to evaluate the biocompatibility of two composite cements over a 90-day period by analyzing individuals' behavior as well conducting macroscopic and histological examinations Computed Tomography (CT) scans. We conducted cytotoxicity test placing materials subcutaneously peri/intramuscularly. Days 30 90 were crucial for our research. On those days, we harvested implants, kidneys liver search any toxic deposits. The biomaterial's uniformity, color texture remained unaltered despite being in intimate contact with tissue. Although slight inflammatory response observed placement location, an improved outcome interaction between material its insertion area. There no notable discoveries kidneys. According obtained results, biomaterials did not produce clinical changes nor specific irritation during research, demonstrating that they are biocompatible biological tissues.

Language: Английский

Citations

1

The Potential of Composite Cements for Wound Healing in Rats DOI Creative Commons
Alina Ioana Ardelean,

Sorin Marian Mârza,

Mădălina Florina Dragomir

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 837 - 837

Published: Aug. 16, 2024

Recent developments in biomaterials have resulted the creation of cement composites with potential wound treatment properties, even though they are currently mainly employed for bone regeneration. Their ability to improve skin restoration after surgery is worth noting. The main purpose this research evaluate composite promote healing a rat experimental model. Full-thickness 5 mm defects were created, and applied as dressings. hybrid light-cured possess an organic matrix (Bis-GMA, TEGDMA, UDMA, HEMA) inorganic phase (bioglasses, silica, hydroxyapatite). also contains γ-methacryloxypropyl-trimethoxysilane, which produced by distributing bioactive silanized filler particles. repair defect assessed using selection macroscopic microscopic protocols, including closure rate, histopathological analysis, cytotoxicity, biocompatibility. Both exerted favorable influence on cells, although C1 product demonstrated more extensive mechanism. Histological examination kidney liver tissues revealed no evidence toxicity. There notable negative outcomes treated groups, demonstrating biocompatibility efficacy these bioproducts. By day 15, both groups had healed completely. This introduces pioneering strategy utilizing cements, traditionally used dentistry, context healing.

Language: Английский

Citations

1

Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements DOI Open Access

Ioana Lacan,

Mărioara Moldovan, Codruţa Saroşi

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(16), P. 5653 - 5653

Published: Aug. 17, 2023

Calcium phosphate cements present increased biocompatibility due to their chemical composition being similar that of the hydroxyapatite in hard tissues living body. It has certain limitations its poor mechanical properties, such as low tensile strength and brittleness. Thus, optimal way improve properties is through design novel composite cements. The purpose was fulfilled using a 25% hydroxyethyl methacrylate (HEMA) mixed with 3% urethane dimethacrzlate (UDMA) base matrix various ratios polyethylene glycol (PEG 400) polycaprolactone (PCL). Mineral filler based on tricalcium (TCP) different chitosan ratio used bio-response enhancer additive. Four mixtures were prepared: S0-unfilled polymer matrix; S1 50% TCP filler; S2 + S3 17.5% nano (HA). testing revealed best compressive obtained by S2, followed S3, worst value for unfilled matrix. same tendency observed flexural strength. These results show system increases resistance Liquid exposure investigation reveals relative constant solubility systems during 21 days exposure: most soluble fillers revealing additivated more than without additives ones. embedding mode into plays key role liquid absorption. additive enhances hydrophobicity UDMA monomer, resulting lowest absorption values, while non-additivated samples are absorbent prevalence hydrolytic aliphatic groups within PEG 400. higher first day immersion, it progressively decreased time swelling surface microstructural features. confirmed changes monitored SEM microscopy. very uniform compact distribution, presents local clustering powder at contact significant pore formation S0 samples, proved be resistant against superficial erosion, proving penetration.

Language: Английский

Citations

1

Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models DOI Creative Commons
Alina Ioana Ardelean,

Sorin Marian Mârza,

Raluca Marica

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1097 - 1097

Published: Aug. 30, 2024

Repairing or reconstructing significant bone defects is typically challenging. In the present study, two composite cements were used as scaffolds in a sub-critical femoral defect rats. A control group and experimental batches to compare outcomes. This research aimed investigate osteogenic potential toxicological tolerance of bioproducts through histopathology computed tomography imaging analysis at 14, 28, 56, 90 days post-implantation. The biomaterials investigation consisted 65% bioactive salinized inorganic filler 25% weight organic matrix. part biomaterial was composed Bis-GMA (bisphenol A-glycidyl methacrylate), UDMA (urethane dimethacrylate), HEMA (2-Hydroxyethyl TEGDMA (triethylene glycol while silica, barium glass, hydroxyapatite, fluor aluminosilicate glass. first findings this are encouraging, revealing that there slight difference between groups treated with biomaterials, but it might be an effective approach for managing abnormalities. Material C1 exhibited faster healing time compared material C2, where fractures occurred some individuals. It unclear if caused by presence C2 whether additional variables blame. By end research, mice appeared tolerate without exhibiting any inflammatory rejection responses.

Language: Английский

Citations

0