Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 83 - 83

Published: Jan. 9, 2025

Cannabinoid compounds have potential as treatments for a variety of conditions, with cannabigerol (CBG) being known its anti-inflammatory properties. In this study, we investigated the effects CBG in cellular model 1-chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD). model, confirmed cytotoxicity and downregulated expression inflammatory markers CCL26, IL1B, IL6, TNF (p < 0.001). mouse clinical, histological, immunological changes were analyzed. The results showed that improved severity score, epidermal thickness, mast cell count reduced cytokines (Tslp, Il1b, Il4, Il6, Il13, Il17, Il18, Il22, Il33) by qRT-PCR Western blot modulated JAK1, JAK2, TYK2, STAT1, STAT2, STAT3, p-STAT3, STAT6, p-STAT6 0.05). Subsequently, p-IκBα, NF-κB, p-NF-κB signaling factors also 0.05), corresponding skin barrier factors. study indicate effectively alleviates AD-like symptoms suggest therapeutic agent.

Language: Английский

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Investigating the Anti-Inflammatory Activity of Various Brown Algae Species

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 457 - 457

Published: Oct. 5, 2024

This literature review investigated the anti-inflammatory properties of brown algae, emphasizing their potential for dermatological applications. Due to limitations and side effects associated with corticosteroids immunomodulators, interest has been growing in harnessing therapeutic qualities from natural products as alternatives traditional treatments skin inflammation. explored bioactive compounds specifically looking into two compounds, namely, fucoidans phlorotannins, which are widely known exhibit properties. synthesized findings various studies, highlighting how these can mitigate inflammation by mechanisms such reducing oxidative stress, inhibiting protein denaturation, modulating immune responses, targeting inflammatory pathways, particularly conditions like atopic dermatitis. The revealed species-specific variations influenced molecular weight sulphate content. Challenges related permeability were addressed, nanoformulations penetration enhancers improve delivery. While vivo results using animal models provided positive results, further clinical trials necessary confirm outcomes humans. concludes that algae hold substantial promise developing new encourages research optimize extraction methods, understand mechanisms, address practical challenges sustainability regulatory compliance. contributes body evidence supporting integration marine-derived applications diseases.

Language: Английский

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The beneficial effects of ethanolic extract of Sargassum serratifolium in DNCB-induced mouse model of atopic dermatitis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 5, 2024

Abstract Atopic dermatitis is a chronic complex inflammatory skin disorder that requires sustainable treatment methods due to the limited efficacy of conventional therapies. Sargassum serratifolium , an algal species with diverse bioactive substances, investigated in this study for its potential benefits as therapeutic agent atopic dermatitis. RNA sequencing LPS-stimulated macrophages treated ethanolic extract (ESS) revealed ability inhibit broad range inflammation-related signaling, which was proven RAW 264.7 and HaCaT cells. In DNCB-induced BALB/c or HR-1 mice, ESS improved symptoms within skin, along histological improvements such reduced epidermal thickness infiltration mast showed tendency improve serum IgE levels cytokine changes, while also improving mRNA expression Chi3l3, Ccr1, Fcεr1a genes skin. Additionally, compounds (sargachromanol (SCM), sargaquinoic acid (SQA), sargahydroquinoic (SHQA)) mitigated responses LPS-treated RAW264.7 macrophages. summary, has anti-inflammatory effect improves dermatitis, may be applied therapeutics

Language: Английский

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Interleukin-4 and Atopic Dermatitis: Why Does it Matter? A Narrative Review

Dermatology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Atopic dermatitis (AD) is a common chronic inflammatory skin condition that significantly impairs patients' quality of life as result intense itching and persistent eczematous lesions. Although AD has multifaceted etiology—including genetic predisposition, environmental triggers, barrier dysfunction, dysregulated immune responses—interleukin-4 (IL-4) recognized central role in its pathogenesis. This narrative review explores the IL-4 pathophysiology AD, contribution to atopic march, therapeutic impact inhibition. plays critical dysbiosis, pruritus, inflammation, all which contribute debilitating symptoms AD. Moreover, implicated other conditions, such asthma, allergic rhinitis, food allergies, underscoring beyond importance march. Recent advances targeted therapies, particularly IL-4/IL-13 signaling inhibitors, have changed management. Dupilumab, an receptor antagonist, demonstrated significant efficacy reducing enhancing patient outcomes both children adults. In addition symptomatic relief, suppressing may also offer potential for disease modification, altering AD's progression possibly preventing onset conditions. highlights crucial target By understanding pathogenesis exploring implications targeting pathways, this work can guide future research concerning treatment approaches emphasize need early interventions mitigate ultimately improve life.

Language: Английский

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Development and Characterization of a Vaccinium vitis-idaea Liposomal Gel for the Treatment of Atopic Dermatitis

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 17, 2025

In this study, a liposomal gel with anti-inflammatory, antibacterial, and antioxidant effects improving atopic dermatitis (AD) was prepared using Vaccinium vitis-idaea polyphenol as the main active ingredient, which is safe, effective, of stable quality has anti-inflammatory antimicrobial effects. The extract from obtained through ultrasonic extraction subsequently purified macroporous resin. A liposome incorporating formulated poloxamer 188 407 base materials. gel's physical characteristics, including appearance, vesicle size, zeta potential, were systematically characterized. Furthermore, its antioxidant, anti-aging, anti-AD assessed both ex vivo in studies. After process optimization, yield 4.33%; encapsulation rate 90.45%. by optimal had potential -33.67 mV, particle size 119 nm, PDI 0.147, showed good stability under conditions 60 °C, 75% relative humidity, light intensity 4500 ± 500 Lux. results vitro studies that polyphenols have antibacterial effects, safe for skin application, effectively reduces dandruff erythema, degree keratinization, congestion inflammatory infiltration local tissues well increasing content collagen fibers tissues, promotes restoration structural integrity skin, reducing factors TNF-α, IL-4. By expression level IL-4, IL-13, MDA, SOD, diversity bacterial flora AD it can play role anti-bacterial, improve symptoms AD. present study demonstrated an ameliorating effect on

Language: Английский

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Subcutaneous Injection and Brush Application of Ovalbumin–Aluminum Salt Solution Induces Dermatitis-like Changes in Mice

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1701 - 1701

Published: March 3, 2025

Background: Intraperitoneal sensitization combined with topical and/or epicutaneous treatment using an ovalbumin (OVA)–aluminum salt solution (OVA-AL) represents a model for inducing atopic dermatitis (AD). However, the combination of subcutaneous and cutaneous application OVA-AL via brush has not been explored as method AD. Methods: Adult mice were subcutaneously injected following on days 0, 7, 14 treated to dorsal skin fortnightly until 35 49. Concomitant alloknesis changes assessed. Mice Balb/c ICR-CD1 strains day 35, only strain continuing Control animals received saline. At 49 days, was harvested processed histological analysis. Results: developed dry skin, no scratching or alloknesis. Histological examination revealed increase in mast cells collagen deposition. Conclusions: Dermatitis-like symptoms observed this administration method.

Language: Английский

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Chlorogenic acid alleviates DNCB-induced atopic dermatitis by inhibiting the Akt1/NF-κB signaling pathway

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177534 - 177534

Published: March 1, 2025

Language: Английский

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Selected traditional Chinese herbal medicines for the treatment of atopic dermatitis - research progress on the effect and mechanism of actions

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Atopic dermatitis (AD) is a common chronic, recurrent, inflammatory skin disease characterized by pruritus, lichen-like changes and dry skin. Due to the complex pathogenesis of AD, its mechanism primarily associated with genetic, barrier dysfunction, environmental, immune factors. AD has been routinely treated glucocorticoids, antihistamines, local immunomodulators, biological agents, small molecules; however, side effects are significant, treatment efficacy limited. In recent years, traditional Chinese medicine (TCM) gradually widely used in AD. Many studies have shown that TCM mainly regulates cytokines, gut microbiota system. Therefore, it plays crucial role The atopic using targeting multiple pathways targets, demonstrates significant therapeutic effects. This paper reviews reports on (including prescription, single TCM, metabolites), which provides theoretical basis for certain It can alleviate treat various ways. We should base our differentiation syndrome differentiation. With help modern medicine, clinical treating be improved.

Language: Английский

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Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Abstract The skin microbiome, consisting of a vast array microorganisms, is essential for human health, aiding in barrier protection, immune regulation, wound repair, and defense against pathogens. Disruptions this microbial balance are closely linked to the onset worsening various disorders. This review evaluates potential microbiome engineering as therapeutic strategy treating diseases. We discuss nontargeted approaches like probiotics fecal microbiota transplantation that aim reshape community, well targeted methods such phage therapy, lysins, engineered bacteria, which specifically modulate populations or influence environment. These open new avenues personalized dermatological treatments. Despite significant progress, challenges remain clinical translation microbiome‐based therapies. Safety, standardization, regulatory approval, long‐term ecological stability must be addressed ensure efficacy reproducibility settings, underscoring critical need further research their applications.

Language: Английский

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Global, regional, and national burden of older adult atopic dermatitis in 204 countries and territories worldwide

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 2, 2025

With the aging global population, older adult atopic dermatitis (AD) is emerging as an increasingly significant health challenge. This study aimed to evaluate burden of AD from 1990 2021 and project its change 2050. The estimates 95% uncertainty intervals prevalence, incidence, disability-adjusted life-years (DALYs) attributable among individuals aged over 60 years were extracted Global Burden Diseases (GBD) Study 2021. We used joinpoint regression analysis, decomposition cross-country inequality frontier analysis prediction model epidemiological analysis. From 2021, prevalence increased 11,009,630 cases (95% UI: 9,915,829 12,170,941), even ASRs declined, which primarily driven by population growth. It was observed that females 75-79 old had higher incidence rates. SDI relative exhibited DALYs rates positively correlated with levels, while SDI-related inequalities a decrease. Predictions up 2050 anticipated increasing numbers, only age-standardized life-year (ASDRs) expected decline. varied genders, age groups, regions, countries climatic conditions. Although shown decline time, remained significant, especially in regions high levels. In future, projected continue rising until 2050, thereby targeted interventions public strategies needed address this trend.

Language: Английский

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