Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T‐cell therapy in solid tumors DOI Creative Commons
Sikun Meng,

Tomoaki Hara,

Yutaka Miura

et al.

Cancer Science, Journal Year: 2024, Volume and Issue: 115(11), P. 3532 - 3542

Published: Aug. 21, 2024

Abstract With recent advances in tumor immunotherapy, chimeric antigen receptor T (CAR‐T) cell therapy has achieved unprecedented success several hematologic tumors, significantly improving patient prognosis. However, solid the efficacy of CAR‐T is limited because high uncertainty and extremely restrictive microenvironment (TME). This challenge led to exploration new targets, among which fibroblast activation protein (FAP) gained attention for its relatively stable specific expression TME various making it a potential target therapy. study comprehensively analyzed biological characteristics FAP discussed application therapy, including theoretical basis, preclinical clinical research progress targeting with treatment. The challenges future optimization directions this treatment strategy were also explored, providing perspectives strategies tumors.

Language: Английский

From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies DOI Open Access
Ehsan Gharib, Gilles A. Robichaud

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9463 - 9463

Published: Aug. 30, 2024

Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential

Language: Английский

Citations

9
Prognostic models of immune-related cell death and stress unveil mechanisms driving macrophage phenotypic evolution in colorectal cancer DOI Creative Commons
Hao Liu, Chuhan Zhang,

Sanfei Peng

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Tumor microenvironment (TME), particularly immune cell infiltration, programmed death (PCD) and stress, has increasingly become a focal point in colorectal cancer (CRC) treatment. Uncovering the intricate crosstalk between these factors can enhance our understanding of CRC, guide therapeutic strategies, improve patient prognosis. We constructed an immune-related stress (ICDS) prognostic model utilizing machine learning methodologies. Furthermore, we performed enrichment analyses deconvolution algorithms to elucidate complex interactions infiltration processes PCD within substantial array transcriptomic data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus base (GEO) related CRC. Single-cell sequencing biochemical experiments were used validate interaction genes tumor cells. ICDS exhibited robust predictive performance seven independent cohorts, revealing inverse correlation scores Meanwhile, index was positively correlated with clinical stage. Model analysis indicated that subgroups low heightened activation features elevated activity pathways. further revealed macrophages central drivers characteristics underlying differences model. Pseudotime cellular gene GAL3ST4 promotes transition toward M2 pro-tumor phenotype. communication experimental validation cuproptosis cells suppress expression, thereby inhibiting M2-like macrophage polarization. In summary, uncovered mechanism by which downregulate expression via inhibit polarization, providing new targets biomarkers for CRC treatment prognosis evaluation.

Language: Английский

Citations

1
Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies? DOI Creative Commons

Marjan Anvar,

Kimiya Rashidan,

Nima Arsam

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 27, 2024

T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells exhibit remarkable plasticity, allowing them to different phenotypes in the cancer microenvironment. This adaptability enables Th17 promote tumor progression by immunosuppressive activities angiogenesis, but also mediate anti-tumor immune responses through employing setting or even directly converting toward Th1 phenotype producing interferon-gamma (IFN-γ). dual role makes it double-edged sword encountering cancer. In this review, we aim elucidate complexities cell function summarizing recent studies and, ultimately, design novel therapeutic strategies, especially targeting milieu, which could pave way more effective treatments.

Language: Английский

Citations

7
Immune landscape and response to oncolytic virus-based immunotherapy DOI

Chaolong Lin,

Wenzhong Teng,

Tian Yang

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(3), P. 411 - 429

Published: March 8, 2024

Language: Английский

Citations

5
Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway DOI Creative Commons
Siqi Feng, Shiying Li,

Zhong-Hua Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118854 - 118854

Published: Sept. 24, 2024

Language: Английский

Citations

5
SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway DOI Creative Commons
Hong Wang, Y. Y. Ji, Shan Deng

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156388 - 156388

Published: Jan. 11, 2025

Language: Английский

Citations

0
The characteristics of the tumor immune microenvironment in colorectal cancer with different MSI status and current therapeutic strategies DOI Creative Commons

Qingzhe Wang,

Min Yu, Shuang Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Colorectal cancer (CRC) remains a significant cause of cancer-related mortality worldwide. Despite advancements in surgery, chemotherapy, and radiotherapy, the effectiveness these conventional treatments is limited, particularly advanced cases. Therefore, transition to novel treatment urgently needed. Immunotherapy, especially immune checkpoint inhibitors (ICIs), has shown promise improving outcomes for CRC patients. Notably, patients with deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) tumors often benefit from ICIs, while majority cases, which exhibit proficient (pMMR) microsatellite-stable (MSS) status, generally show resistance this approach. It assumed that MSI phenotype some changes tumor microenvironment (TME), thus triggering antitumor immunity leading response immunotherapy. Understanding differences TME relative status essential developing more effective therapeutic strategies. This review provides an overview components explores current approaches aimed at enhancing ICI efficacy MSS CRC.

Language: Английский

Citations

0
Unveiling the orchestration of T-cell dynamics: A comprehensive examination of their crucial role in revolutionizing immunotherapy for pancreatic and colon cancers DOI

Sridevi Mardham,

Soumya Dakshinamurthy

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 199 - 232

Published: Jan. 1, 2025

Language: Английский

Citations

0
CD155 promotes the progression of colorectal cancer by restraining CD8+ T cells via the PI3K/AKT/NF-κB pathway DOI Creative Commons

Rongpu Liang,

Liting Liu,

Dongbing Ding

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(3)

Published: Feb. 1, 2025

CD155 is a crucial factor in the regulation of T cell function and contributes to immune escape. upregulation has been found several types cancer. However, mechanism by which regulates CD8+ colorectal cancer remains unclear. Here we investigated role function. We studied expression tissues through western blot, immunohistochemistry, TCGA database. verified effects on functions cells vitro experiments. demonstrated that affects migration thus promotes tumor growth mouse subcutaneous model. then tested changes PI3K/AKT/NF-κB pathway flow cytometry. stable was negatively correlated with prognosis patients. In experiments confirmed does not affect proliferation, migration, or invasion. also revealed downregulated vivo vitro. Furthermore, might regulate via pathway. This study can promote progression regulating PI3K / AKT-NF-κB depletion reduce their microenvironment. may become an important prognostic biomarker effective target for immunotherapy.

Language: Английский

Citations

0
Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer DOI Creative Commons
Yuanyuan Wang, Chenxi Hu,

Tianpeng Du

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

Introduction Identification of effective therapies for colorectal cancer (CRC) remains an urgent medical need, especially the microsatellite stable (MSS) phenotype. In our previous study, potassium oxonate (PO), a uricase inhibitor commonly used elevating uric acid in mice, unexpectedly showed remarkable inhibition tumor growth when combined with anti-programmed death-1 (PD-1). Further research demonstrated that combination and anti-PD-1 could reprogram immune microenvironment. This study aimed to explore anti-tumor effect PO anti-PD-1, investigate impact on immunosuppressive microenvironment (TME). Methods We established syngeneic mouse model CRC divided into groups control group, single drugs group group. Use HE staining, immunohistochemistry (IHC) TUNEL staining issues verify anti-neoplasm each also tested changes TME through flow cytometry spleen mice as well IHC cytokines. Results The co-therapy admirable compared drug groups. were tended environment beneficial killing tumors by enhancing chemotactic factor release, increasing CD8+ T cell infiltration activation, decreasing amount regulatory cells. Moreover, IFN-γ IL-2 secretion found be enriched TME. Conclusion Our indicated synergistically suppress progression altered favor antitumor responses.

Language: Английский

Citations

0