Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 124, P. 108534 - 108534

Published: Jan. 6, 2024

Language: Английский

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Maternal Oxidative Stress Throughout Pregnancy and Early Childhood Neurodevelopment at Different Stages: Insights from a Prospective Cohort Study

Published: Jan. 1, 2025

Abstract Background: Maternal oxidative stress during pregnancy plays as hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal biomarkers across and neurodevelopmental outcomes different stages early childhood. Methods: This is a cohort study conducted 1791 mother-child pairs from Wuhan, China. Three biomarkers, including DNA biomarker (8-hydroxy-2'-deoxyguanosine, 8-OHdG), RNA (8-hydroxyguanosine, 8-OHG), lipid (4-hydroxy nonenal mercapturic acid, HNE-MA), were measured repeatedly collected urine samples three trimesters pregnancy. We followed children at age 2, 3, 4-6 years. At Bayley Scales was employed assess children's mental psychomotor development. Brain-derived neurotrophic (BDNF) levels plasma 3. The Wechsler Preschool Primary Scale - Fourth Edition (WPPSI-IV) used intelligence quotients ages 4-6. Generalized estimating equations performed explore outcomes. Results: Higher HNE-MA late-pregnancy associated with lower development index 2 (β: -0.95; 95% CI: -1.78∼ -0.11). Elevated early- mid-pregnancy decreased BDNF 3 -0.07; -0.13∼ -0.01). Each unit increase natural log-transformed (Ln) 8-OHdG 8-OHG concentrations decrease full-scale quotient 5.94 years -1.55 points (95% -2.84 ∼ -0.26) -1.89 -3.30 -0.49), respectively. Conclusion: suggested that higher each trimester might be risk consistently suboptimal childhood, pre-school ages.

Language: Английский

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From Pregnancy to Breastfeeding: The Role of Maternal Exercise in Preventing Childhood Obesity

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 660 - 660

Published: Feb. 12, 2025

Low adherence to healthy lifestyle behaviors during pregnancy and lactation is strongly associated with a higher risk of childhood obesity. This narrative review aims elucidate summarize the pivotal role played by physical activity (PA) breastfeeding, highlighting potential mechanisms linking PA in these periods prevention Maternal exercise breastfeeding significantly reduces obesity enhancing fetal metabolism, supporting maternal weight management, promoting improved practices. Pregnancy postpartum period represent critical windows for implementing preventive strategies that benefit both mother child. Encouraging an active vital public health strategy extensive benefits. Healthcare professionals play crucial creating supportive environments providing tailored guidance empower mothers engage regular PA. approach not only enhances individual outcomes but also contributes broader goal fostering healthier communities.

Language: Английский

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Exploring the nonlinear association between cardiometabolic index and hypertension in U.S. Adults: an NHANES-based study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

Hypertension is a prevalent chronic disease affecting over 1.2 billion people worldwide, representing major modifiable risk factor for cardiovascular diseases. The Waist-to-Height Ratio (WHtR) and Triglyceride to High-Density Lipoprotein Cholesterol (TG/HDL-C) ratio are established metabolic indicators linked the of Recently, Cardiometabolic Index (CMI), combining WHtR TG/HDL-C ratios, has been proposed provide comprehensive assessment health. This study investigates association between CMI hypertension using data from National Health Nutrition Examination Survey (NHANES). utilized NHANES nine cycles spanning 2001 2018, encompassing 20,049 participants aged 20. Exclusions were made individuals with incomplete or data, pregnant women. was calculated by multiplying ratio. defined according American Heart Association guidelines. relationship evaluated multivariate logistic regression analyses, additional subgroup analyses conducted based on demographic factors. Nonlinear relationships analyzed smoothing curve fitting techniques. identified significant positive correlation risk, an increase one unit in associated 9% heightened (OR: 1.09, 95% CI: 1.05, 1.13). remained across various subgroups. A nonlinear observed, critical threshold 2.64. Below this threshold, higher values progressively prevalence hypertension, whereas beyond further increases did not significantly correlate elevated hypertension. demonstrates that may serve as valuable tool early screening assessment, particularly identifying at before reaching threshold. These results underscore importance addressing health prevention management Future research should focus longitudinal studies establish causality, explore clinical utility screening, examine its applicability diverse populations.

Language: Английский

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Parkinson’s Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3348 - 3348

Published: April 3, 2025

Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA's typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson's spectrum mechanisms to explore hypothetical for how pregnancy-induced physiological changes might influence progression. Pregnancy-induced hormonal fluctuations, including elevated estrogen progesterone levels, may modulate α-synuclein aggregation neuroinflammatory pathways. Immune adaptations, such as fetal microchimerism Th2-biased immune profiles, introduce additional complexities, particularly donor embryo complex microchimerism. Metabolic demands oxidative stress further intersect with these mechanisms, potentially accelerating disease We analyze existing literature theoretical models, emphasizing need interdisciplinary research. Clinical implications are discussed propose evidence-based strategies optimizing maternal-fetal outcomes. This paper identifies critical knowledge gaps proposes avenues future investigation optimize outcomes unique underexplored intersection.

Language: Английский

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Antioxidants and Pregnancy Complications: Exploring Therapeutic Strategies for Better Outcomes

Clinical Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 7(1), P. 001 - 006

Published: Jan. 25, 2024

Pregnancy complications present significant challenges, impacting maternal health and fetal development. Oxidative stress, a key contributor to various pregnancy-related disorders such as preeclampsia, gestational diabetes mellitus (GDM), preterm birth, has spurred interest in exploring antioxidant interventions. Antioxidants, known for their ability counteract oxidative damage, have emerged potential therapeutic agents mitigate these complications. This paper synthesizes current knowledge on the role of antioxidants pregnancy, elucidating mechanisms action, sources, impact stress-related It examines diverse compounds, including vitamins C E, selenium, natural phytochemicals, highlighting modulate stress pathways promote maternal-fetal well-being. Furthermore, this critically analyzes clinical studies, meta-analyses, preclinical research efficacy safety supplementation during pregnancy. discusses complexities surrounding optimal dosages, timing, formulations antioxidants, aiming delineate strategies integration into prenatal care. In conclusion, review provides insights promising alleviate pregnancy associated with stress. highlights avenues future research, advocating deeper understanding utilization care enhance outcomes.

Language: Английский

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Maternal Obesity Alters Placental and Umbilical Cord Plasma Oxidative Stress, a Cross-Sectional Study

Published: Aug. 30, 2024

Maternal obesity has been found to be impaired oxidative status in placenta and newborn which can lead adverse pregnancy outcomes long-term influence on metabolic programming the offspring. This study aimed investigate role of maternal umbilical cord plasma placental adaptation. (n=20) defined as pre-pregnancy BMI ≥ 25 kg/m2 lean < were recruited into this study. Both groups matched by gestational age at delivery. blood, blood tissue collected assess nutritional content (cholesterol, triglyceride, protein), stress marker (MDA protein carbonyl) antioxidant activity (SOD catalase). Placenta expression (SOD2, catalase, UCP2 Nrf2) was evaluated western blot analysis. Catalase significantly increased group (p = 0.0200) with an trend MDA carbonyl levels. Umbilical catalase compared that 0.0462, 0.0485, 0.0348, respectively). Although analysis exhibited significant decreased SOD2 0.0169) 0.0067), accompanied Nrf2 downregulation 0.0453). An mitochondrial expressions observed 0.0143). Hence, our provided evidence is associated fetal parallel expression.

Language: Английский

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Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: 37(3), P. 237 - 250

Published: Feb. 19, 2024

Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal with offspring neurodevelopment, providing update (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, implications for health.

Language: Английский

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Fetal and obstetrics manifestations of mitochondrial diseases

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 23, 2024

Abstract During embryonic and neonatal development, mitochondria have essential effects on metabolic energetic regulation, shaping cell fate decisions leading to significant short- long-term offspring health. Therefore, perturbation mitochondrial function can a pathological effect pregnancy. Several shreds of evidence collected in preclinical models revealed that severe dysfunction is incompatible with life or leads critical developmental defects, highlighting the importance correct during embryo-fetal development. The mechanism impairing development unknown may include dysfunctional switch differentiating cells due decreased ATP production altered apoptotic signalling. Given central role fetal typical Mitochondrial Diseases (MDs) should, principle, be detectable However, little known about clinical manifestations MDs In this manuscript, we review suggesting affect highlight maternal outcomes provide wake-up call for targeted genetic diagnosis.

Language: Английский

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Metabolomics Application in Understanding the Link Between Air Pollution and Infant Health Outcomes: A Narrative Review

Current Pollution Reports, Journal Year: 2024, Volume and Issue: 10(4), P. 786 - 798

Published: May 3, 2024

Language: Английский

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