Truncated TrkB: The predominant TrkB Isoform in Nociceptors DOI Creative Commons
Jaclyn Merlo,

Fang-Mei Chang,

Michael Tran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, neuronal expression and function has been associated with non-nociceptive Aδ low-threshold mechanoreceptors. This study challenges prevailing assumptions by demonstrating that TrkBT1 is the predominant isoform expressed neurons plays functional role modulating activity. We demonstrate nociceptors, identified markers such as TRPV1, TRPA1, TRPM8 5HT3A, well non-nociceptors, while (TrkBTK+) restricted to subpopulation. Functionally, we show acute application BDNF induces modest calcium influx nociceptors prolonged exposure significantly potentiates capsaicin-induced influx, an effect blocked TrkB-specific antagonist ANA12. Additionally, also promotes survival both nociceptive culture, dependent on Our data reveal ANA12 inhibits BDNF-mediated sensitization concentration-dependent manner, implicating distinct signaling pathways these processes. Collectively, our findings redefine modulator nociceptor activity rather than passive TrkB. By uncovering its dual roles survival, this provides new insights into molecular mechanisms BDNF/TrkB pain. Future work evaluating biology could offer perspectives how receptor contributes plasticity during chronic pain conditions.

Language: Английский

Brain-Derived Neurotrophic Factor, Nociception, and Pain DOI Creative Commons
Adalberto Merighi

Biomolecules, Journal Year: 2024, Volume and Issue: 14(5), P. 539 - 539

Published: April 30, 2024

This article examines the involvement of brain-derived neurotrophic factor (BDNF) in control nociception and pain. BDNF, a neurotrophin known for its essential role neuronal survival plasticity, has garnered significant attention potential implications as modulator synaptic transmission. comprehensive review aims to provide insights into multifaceted interactions between BDNF pain pathways, encompassing both physiological pathological conditions. I delve molecular mechanisms underlying BDNF's processing discuss therapeutic applications mimetics managing Furthermore, highlight recent advancements challenges translating BDNF-related research clinical practice.

Language: Английский

Citations

13
Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation DOI Creative Commons

Saniyya Khan,

Feng Tao

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 434 - 434

Published: Feb. 11, 2025

Background and Objectives: Orofacial pain corresponds to sensitization originating from the facial oral regions, often accompanied by diagnostic complexity due a multitude of contributory factors, leading significant patient distress impairment. Here, we have reviewed current mechanistic pathways biochemical aspects complex orofacial pathology, highlighting recent advancements in understanding its multifactorial regulation signaling thus providing holistic approach challenging it. Materials Methods: Studies were identified an online search PubMed database without any time range. Results: We discussed neuron–glia interactions glial cell activation terms immunomodulatory effects, metabolism reprogramming effects epigenetic modulatory response comprising different factors. highlighted fundamental role oxidative stress affecting cellular as well machinery, which renders pathology intricate multidimensional. Emerging research on modulation regulatory genes molecular environmental factors is also discussed, alongside updates novel treatment approaches. Conclusions: This review deliberates integrative perspectives implications immune system, glucose metabolism, lipid redox homeostasis mitochondrial dysfunction accommodating effect dysregulated non-coding RNAs for interdisciplinary at level, aiming improve outcomes with precise diagnosis offering improved management treatment.

Language: Английский

Citations

1
Neuropathic pain in cats: Mechanisms and multimodal management DOI Creative Commons
Clare Rusbridge

Journal of Feline Medicine and Surgery, Journal Year: 2024, Volume and Issue: 26(5)

Published: May 1, 2024

Practical relevance: Chronic pain is a significant welfare concern in cats, and neuropathic pain, which arises from aberrant processing of sensory signals within the nervous system, subcategory this type pain. To comprehend condition how multimodal pharmacotherapy plays central role alleviating discomfort, it crucial to delve into anatomy nociception perception. In addition, there an intricate interplay between emotional health chronic understanding addressing factors that contribute perception, vice versa, essential for comprehensive care. Clinical approach: Neuropathic suspected if abnormal sensation area distribution together with positive response trial treatment drugs effective Ideally, clinical suspicion would be supported by confirmation lesion at neurolocalisation using diagnostic modalities such as MRI neuroelectrophysiology. Alternatively, may history known trauma site. A variety therapies, including analgesic, anti-inflammatory adjuvant drugs, neuromodulation (eg, TENS or acupuncture), can employed address different facets pathways. Aim: This review article, aimed primary care/ general practitioners, focuses on identification management cats. Three case vignettes are included structured algorithm presented guide veterinarians tailoring interventions. Evidence base: The draws current literature, where available, along author's extensive experience research.

Language: Английский

Citations

6
Truncated TrkB: The predominant TrkB Isoform in Nociceptors DOI
Jaclyn Merlo,

Fang-Mei Chang,

Michael Tran

et al.

Journal of Pain, Journal Year: 2025, Volume and Issue: 31, P. 105409 - 105409

Published: April 23, 2025

Language: Английский

Citations

0
Asarum sieboldii, a Potential Ethnomedicinal Herb in Dentistry and Oral Health DOI

Kenneth Happy,

Joyce Mudondo, Nam–Hui Yim

et al.

International Dental Journal, Journal Year: 2025, Volume and Issue: 75(4), P. 100816 - 100816

Published: May 5, 2025

Language: Английский

Citations

0
Brain-Derived Neurotrophic Factor, Nociception and Pain DOI Open Access
Adalberto Merighi

Published: Feb. 9, 2024

This review article discusses the involvement of Brain-Derived Neurotrophic Factor (BDNF) in control pain. BDNF, a neurotrophin known for its essential role neuronal survival and plasticity, has garnered significant attention potential implications as modulator nociception comprehensive aims to provide insights into multifaceted interactions between BDNF pain pathways, encompassing both physiological pathological conditions. I delve molecular mechanisms underlying BDNF's processing discuss therapeutic applications mimetics managing Furthermore, highlight recent advancements challenges translating BDNF-related research clinical practice.

Language: Английский

Citations

3
Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP) DOI Creative Commons
Federica Canfora, Giulia Ottaviani, Elena Calabria

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3266 - 3266

Published: Dec. 9, 2023

In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, ICHD-3, for their limitations in addressing COFP's complexity. Firstly, study outlines burden of importance distinguishing between different types effective treatment. It then delves into specific challenges diagnosing COFP, emphasizing need a more nuanced approach that incorporates biopsychosocial model. This critically examines existing classification highlighting fully capturing multifaceted nature. advocates integration these systems with DSM-5's Somatic Symptom Disorder code, proposing unified, multidisciplinary approach. recommendation aims to improve coding standardization acknowledge complex interplay biological, psychological, social factors COFP. conclusion, here, we highlight comprehensive, universally applicable system Such would enable accurate diagnosis, streamline treatment strategies, enhance communication among healthcare professionals. advancement holds potential significant contributions research patient care challenging field, offering broader perspective scientists across disciplines.

Language: Английский

Citations

6
Neuroprotective Effect of Nosustrophine in a 3xTg Mouse Model of Alzheimer’s Disease DOI Creative Commons
Iván Carrera, Lola Corzo,

Olaia Martínez-Iglesias

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1306 - 1306

Published: Sept. 15, 2023

Neurodegeneration, characterized by the progressive deterioration of neurons and glial cells, is a feature Alzheimer's disease (AD). The present study aims to demonstrate that onset early progression neurodegenerative processes in transgenic mice models AD can be delayed cocktail neurotrophic factors derived peptides named Nosustrophine, nootropic supplement made peptide complex extracted from young porcine brain, ensuring neuroprotection improving neuro-functional recovery. Experimental 3xTg-APP/Bin1/COPS5 were treated with Nosustrophine at two different ages, their neuropathological hallmark behavior response analyzed. Results showed increased activity immune system reduced pathological changes hippocampus cortex halting development amyloid plaques, mainly seen 3-4 months age, indicating its effect more preventive than therapeutic. Taken together, results indicate potent neuroprotective stimulating effects on neuronal plasticity. This shows for first time an effective therapy using supplements against degenerative diseases, although further investigation needed understand molecular pathways.

Language: Английский

Citations

5
Truncated TrkB: The predominant TrkB Isoform in Nociceptors DOI Creative Commons
Jaclyn Merlo,

Fang-Mei Chang,

Michael Tran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, neuronal expression and function has been associated with non-nociceptive Aδ low-threshold mechanoreceptors. This study challenges prevailing assumptions by demonstrating that TrkBT1 is the predominant isoform expressed neurons plays functional role modulating activity. We demonstrate nociceptors, identified markers such as TRPV1, TRPA1, TRPM8 5HT3A, well non-nociceptors, while (TrkBTK+) restricted to subpopulation. Functionally, we show acute application BDNF induces modest calcium influx nociceptors prolonged exposure significantly potentiates capsaicin-induced influx, an effect blocked TrkB-specific antagonist ANA12. Additionally, also promotes survival both nociceptive culture, dependent on Our data reveal ANA12 inhibits BDNF-mediated sensitization concentration-dependent manner, implicating distinct signaling pathways these processes. Collectively, our findings redefine modulator nociceptor activity rather than passive TrkB. By uncovering its dual roles survival, this provides new insights into molecular mechanisms BDNF/TrkB pain. Future work evaluating biology could offer perspectives how receptor contributes plasticity during chronic pain conditions.

Language: Английский

Citations

0