Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 973 - 973

Published: Jan. 12, 2024

Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals human body. also been shown be beneficial mitigating oxidative stress-induced damage through its anti-inflammatory anti-apoptotic pathways. We aim conduct systematic review evaluate potential benefits hydrogen-rich water. The protocol was uploaded on PROSPERO. After initial search criteria, articles were reviewed by two blinded investigators, total 25 included review. various aspects health, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental COVID-19, stress, anti-aging research, are subject growing interest ongoing research. Although preliminary results clinical trials studies encouraging, further research with larger sample sizes rigorous methodologies needed substantiate these findings. Current needs fully explain mechanisms behind Continued scientific exploration will provide valuable insights into an adjunctive future.

Language: Английский

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Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD)

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17514 - 17514

Published: Dec. 15, 2023

Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common in Western countries and the major cause of cirrhosis or hepatocellular carcinoma (HCC) addition to viral hepatitis recent decades. Furthermore, studies have shown that NAFLD is inextricably linked development extrahepatic diseases. However, there currently no effective treatment cure NAFLD. In addition, 2020, was renamed metabolic dysfunction (MAFLD) show its pathogenesis closely related disorders. Recent reported MAFLD associated with mitochondrial hepatocytes hepatic stellate cells (HSCs). Simultaneously, stress caused by structural functional disorders stimulates occurrence accumulation fat lipo-toxicity HSCs. interaction between liver-gut axis also a new point during MAFLD. this review, we summarize effects several potential strategies for MAFLD, including antioxidants, reagents, intestinal microorganisms metabolites.

Language: Английский

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Hydrogen-rich water ameliorates imiquimod-induced psoriasis-like skin lesions and regulates macrophage polarization in dyslipidemic ApoE-deficient mice

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 992, P. 177363 - 177363

Published: Feb. 7, 2025

Language: Английский

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Impairment of platelet mitochondrial respiration in patients with chronic kidney disease with and without diabetes

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Chronic kidney disease (CKD) and diabetic (DKD) are major public health problems, their burden is growing relentlessly with the aging of global population. Their early recognition now a priority, there an unmet need for identification specific biomarkers in minimally invasive or non-invasive samples. Mitochondrial dysfunction plays pivotal role development progression both CKD DKD circulating platelets have emerged as ideal candidate assessment respiratory function. The present study assessed mitochondrial respiration isolated from peripheral blood patients compared to healthy controls. included total number 89 subjects, follows: 30 divided into three subgroups based on urinary albumin-to-creatinine ratio (uACR): 20 normoalbuminuric, 10 microalbuminuric, macroalbuminuric, 29 (positive controls) individuals (negative controls). Platelets were by differential centrifugations high-resolution respirometry protocol was adapted assess dependent complex I (CI) II (CII). A significant reduction CI-supported active found normoalbuminuric further decreased microalbuminuric subgroup. Both CI CII-dependent coupled maximal uncoupled significantly reduced macroalbuminuric In conclusion, impairment evident stages DKD. Moreover, platelet more severely impaired those CKD. Further, extensive follow-up studies warranted determine whether could serve biomarker and/or prognostic tool

Language: Английский

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Mechanisms and Application of Gas-Based Anticancer Therapies

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1394 - 1394

Published: Oct. 2, 2023

Cancer is still one of the major factors threatening public health, with morbidity and mortality rates at forefront world. Clinical drawbacks, such as high toxicity side effects drug therapy, easy recurrence after surgery affect its therapeutic effect. Gas signaling molecules are essential in maintaining biological homeostasis physiological functions specific chemical substances for information transfer. In recent years, regulatory gas cancer process have been gradually revealed shown broad application prospects tumor therapy. this paper, standard therapies classified introduced. Taking H2, CO2, NO, CO, H2S, SO2 gases examples, research progress malignant tumors mainly introduced terms characteristics, anticancer mechanisms, treatment strategies. Finally, problems developing drugs outlined.

Language: Английский

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Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1444 - 1444

Published: June 28, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive fat accumulation in the liver. Intracellular oxidative stress induced lipid leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H

Language: Английский

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Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36401 - e36401

Published: Aug. 1, 2024

Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits. A randomized, placebo-controlled trial was conducted assess the potential blood uric acid-lowering effects HRW consumption with different doses (low high doses) duration (4 8 weeks) in patients hyperuricemia. The Placebo group consumed three bottles ordinary drinking (330 mL per bottle), Low-HRW two bottle, H2 ≥ 4.66 mg/L) a bottle water, High-HRW daily for weeks. primary outcome acid levels following time points compared baseline. total 100 participants completed entire (32 Placebo, 35 Low-HRW, 33 groups). high-dose more effective than low-dose controlling acid. Following an 8-week period, exhibited significant reduction baseline (488.2 ± 54.1 μmol/L 446.8 57.1 μmol/L, P < 0.05). As rather safe agent, prolonged may be feasible management chictr.org.cn, identifier ChiCTR2200066369.

Language: Английский

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The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis

International Journal of Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 22(3)

Published: Sept. 30, 2024

Metabolic disorders are a growing global concern, especially in developed countries, due to their increasing prevalence. Serum lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density (LDL), commonly used clinical biomarkers for monitoring the progression of these metabolic abnormalities. In recent decades, hydrogen-rich water (HRW) has gained attention as safe effective treatment, with regulatory effects on peroxidation inflammatory responses trials. This systematic review meta-analysis aim evaluate effectiveness HRW therapy blood profiles randomized controlled trials (RCTs) disorders. Following PRISMA guidelines, search RCT studies was conducted PubMed, Web Science, Embase, Google Scholar databases up January 2024. Eight that met all eligibility criteria, RCTs involving dysfunctions evaluations were included further analysis. Data extraction followed by quality evaluation using Jadad scoring system. Meta-analysis STATA software. The eight selected 357 patients various All showed either no or low risk bias. overall levels TG [95% CI: -0.27 (-0.47, -0.07)], TC -0.07 (-0.32, -0.18)], LDL -0.06 (-0.28, 0.15)] demonstrated slight decreases across studies. However, there some heterogeneity HDL -0.11 (-0.37, 0.14)] among (I² = 37.32%). Meta-regression analysis indicated positive association between outcomes duration intervention moderating factor. Hydrogen-rich modest lipid-lowering observed variations, long-term larger populations needed clarify inconsistencies.

Language: Английский

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Mitochondria as a key target of molecular hydrogen

PULMONOLOGIYA, Journal Year: 2024, Volume and Issue: 34(1), P. 59 - 64

Published: Jan. 13, 2024

The aim of the work was to systematize data on biologically significant effects molecular hydrogen uncover mechanisms its effect human body. paper analyzes literature administered in form inhalation and hydrogenenriched water body, laboratory mammals (rats, mice), model cell systems vitro . As a result, mechanism has been proposed according which, addition already known neutralizing highly reactive oxygen species, there is at least one other group molecules that are target These porphyrins, which part hemoproteins, particularly cytochromes mitochondrial respiratory chain. In presence high concentrations carbon dioxide, formed tricarboxylic acid cycle matrix, damages some hemes as result covalent binding CO them. At low doses hydrogen, this causes moderate decrease potential stimulates adaptive response including activation transcription factor Nrf2, expression heme oxygenase antioxidant defense enzymes, mitophagy, renewal population cell. Conclusion. Molecular an adaptogen hormesis – strengthening body’s bioenergetic systems.

Language: Английский

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Analysis of the improved mechanism of Rhodobacter sphaeroides VK-2-3 coenzyme Q10 by reverse metabolic engineering

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Coenzyme Q10 (CoQ10) is an essential medicinal ingredient. In this study, we obtained a high-yielding mutant strain of CoQ10, VK-2-3, by subjecting R. sphaeroides V-0 (V-0) to 12 C 6+ heavy ion beam and high-voltage prick electric field treatment. To investigate the mutation mechanism, complete genomes VK-2-3 were sequenced. Collinearity analysis revealed that nicotinamide adenine dinucleotide-dependent dehydrogenase (NAD) gene underwent rearrangement in genome. The NAD was overexpressed silenced V-0, construct named RS.NAD RS.ΔNAD. results showed titers CoQ10 RS.ΔNAD increased decreased 16.00 33.92%, respectively, compared those these differences significant. Our mechanism which yield increases through reverse metabolic engineering, providing insights for genetic breeding mechanistic analysis.

Language: Английский

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