Changes in the gut microbiota in autism in children: pathogenetic significance and ways of correction DOI Open Access
Galina I. Smirnova, Alena Valerievna Mulenkova, Polina S. Susloparova

et al.

Russian Pediatric Journal, Journal Year: 2023, Volume and Issue: 26(5), P. 360 - 367

Published: Oct. 31, 2023

A systematic review of data on the interrelationship between gut microbiota and autism spectrum disorder (ASD) in children is presented. The search was conducted Pubmed, Google Academic, Web Science databases for keywords: autism, disorder, microbiota. Articles published January 2000 August 2023 were reviewed, preference given to obtained recent years. It found that 40% ASD have various forms severity manifestations gastrointestinal dysfunction (constipation, diarrhea, chronic abdominal pain, etc.), which accompany psychopathological symptoms correlate with ASD. Disorders intestinal are detected more than 80% cases children. At same time, it representatives fila Firmicutes, Bacteroidetes Proteobacteria most common children, although their qualitative quantitative ratios differ. In patients ASD, a decrease content phylum Firmicutes relatively high prevalence producing short-chain fatty acids revealed, due this, they can influence central nervous system behaviour autism. Differences biodiversity determined by heterogeneity demographic geographical characteristics, differences diet, concomitant pathology, behavioural symptoms, different methods analysis treatment. Modification microbiome fecal transplantation potentially promising way improve

Language: Английский

Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder DOI

Cong-Ya Chen,

Yufei Wang, Lan Lei

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122815 - 122815

Published: June 11, 2024

Language: Английский

Citations

19
Regulatory role of S1P and its receptors in sepsis-induced liver injury DOI Creative Commons
Bin Wang, Xiaoyu Wu,

Cheng Jiang-feng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

As an immune and metabolic organ, the liver affects progression prognosis of sepsis. Despite severe adverse effects sepsis injury on body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) regulate downstream pathways involved in pathophysiological processes sepsis, including endothelial permeability, cytokine release, vascular tone. This review summarizes current research role S1P normal biology describes mechanisms by which changes S1P/S1PR affect development liver-related diseases. At same time, pathological underlying injury, as evidenced clinical manifestations during were comprehensively reviewed. paper focused mechanistic through its modulate immunity, bile acid metabolism, liver-intestinal circulation septic injury. Finally, relationships between with inflammation metabolism use related drugs for examined. By elucidating receptor pathogenesis this established molecular targeting framework, providing novel insights into drug development.

Language: Английский

Citations

0
Unraveling the Role of the Glycogen Synthase Kinase-3β, Bruton’s Tyrosine Kinase, and Sphingosine 1 Phosphate Pathways in Multiple Sclerosis DOI

Rupali Mohite,

Sankalp Gharat, Gaurav Doshi

et al.

Endocrine Metabolic & Immune Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 24(10), P. 1131 - 1145

Published: Feb. 2, 2024

: Inflammation, demyelination, and neurodegeneration are symptoms of the central nervous system (CNS) condition known as Multiple sclerosis (MS). Due to its crucial function in controlling immune cell activation inflammation, glycogen synthase kinase-3β (GSK- 3β), Bruton's tyrosine kinase (BTK), Sphingosine 1 phosphate (S1P) signaling pathway have become a viable target for therapy MS. The GSK-3β system, which controls several biological processes, including survival, proliferation, depends on enzyme. In MS animal models human studies, inhibition has been demonstrated lessen demyelination inflammation. Clinical research that BTK inhibitors decrease inflammation disease activity by preventing B subsequent release cytokines. investigations S1P modulators, such fingolimod, lower limiting migration cytokine production. /BTK/S1P is subject this paper's summary discussion prospective treatment targets.

Language: Английский

Citations

0
Beyond Metabolic Messengers: Bile Acids and TGR5 as Pharmacotherapeutic Intervention for Psychiatric Disorders DOI Creative Commons

Arief Gunawan Darmanto,

Ting‐Lin Yen, Jing‐Shiun Jan

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107564 - 107564

Published: Dec. 1, 2024

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed current treatments. This review explores emerging role of bile acids TGR5 receptor in pathophysiology psychiatric conditions, emphasizing their signaling within gut-brain axis. We detail synthesis systemic functions acids, transformation gut microbiota, impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety schizophrenia, autism spectrum bipolar disorder. The highlights how dysbiosis altered acid metabolism contribute to development exacerbation these through mechanisms involving inflammation, oxidative stress, neurotransmitter dysregulation. Importantly, we both pharmacological non-pharmacological interventions that modulate signaling, offering potential breakthroughs treatment strategies. These include dietary adjustments enhance beneficial production use specific agonists have shown promise preclinical clinical settings for regulatory effects on critical pathways such as cAMP-PKA, NRF2-mediated antioxidant responses, neuroinflammation. By integrating findings from dynamics metabolism, related events, this underscores cutting-edge therapeutic approaches poised revolutionize management disorders.

Language: Английский

Citations

0
Changes in the gut microbiota in autism in children: pathogenetic significance and ways of correction DOI Open Access
Galina I. Smirnova, Alena Valerievna Mulenkova, Polina S. Susloparova

et al.

Russian Pediatric Journal, Journal Year: 2023, Volume and Issue: 26(5), P. 360 - 367

Published: Oct. 31, 2023

A systematic review of data on the interrelationship between gut microbiota and autism spectrum disorder (ASD) in children is presented. The search was conducted Pubmed, Google Academic, Web Science databases for keywords: autism, disorder, microbiota. Articles published January 2000 August 2023 were reviewed, preference given to obtained recent years. It found that 40% ASD have various forms severity manifestations gastrointestinal dysfunction (constipation, diarrhea, chronic abdominal pain, etc.), which accompany psychopathological symptoms correlate with ASD. Disorders intestinal are detected more than 80% cases children. At same time, it representatives fila Firmicutes, Bacteroidetes Proteobacteria most common children, although their qualitative quantitative ratios differ. In patients ASD, a decrease content phylum Firmicutes relatively high prevalence producing short-chain fatty acids revealed, due this, they can influence central nervous system behaviour autism. Differences biodiversity determined by heterogeneity demographic geographical characteristics, differences diet, concomitant pathology, behavioural symptoms, different methods analysis treatment. Modification microbiome fecal transplantation potentially promising way improve

Language: Английский

Citations

1