Urban Science,
Journal Year:
2024,
Volume and Issue:
8(4), P. 230 - 230
Published: Nov. 28, 2024
This
study
assessed
PM2.5
concentrations
and
heavy
metal
composition
in
blacksmith
workshops
located
Mekarmaju
village,
Bandung
Regency,
Indonesia.
The
levels
measured
across
seven
showed
significantly
elevated
concentrations,
ranging
from
166.88
µg/m3
to
513.80
µg/m3,
greatly
exceeding
the
indoor
air
quality
recommended
by
World
Health
Organization
(WHO).
Chemical
analysis
revealed
toxic
metals
within
PM2.5,
including
iron
(Fe),
chromium
(Cr),
nickel
(Ni),
manganese
(Mn),
zinc
(Zn),
lead
(Pb),
with
total
varying
between
workshops.
highest
concentration
was
recorded
workshop
B
(61.8
µg/m3),
while
lowest
F
(6.1
µg/m3).
These
are
associated
severe
health
risks
such
as
respiratory
cardiovascular
diseases,
neurotoxicity,
increased
cancer
risk
prolonged
exposure.
Strong
correlations
Fe,
Cr,
Mn
indicate
that
emissions
metalworking
processes
primary
sources
of
pollution.
Although
this
pilot
provides
crucial
baseline
data,
limitations
a
short
sampling
duration
small
sample
size
suggest
need
for
further
research.
Future
studies
should
include
long-term,
continuous
monitoring
detailed
chemical
speciation
enhance
our
understanding
occupational
risks.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(3), P. 512 - 512
Published: Jan. 24, 2024
Iron
(Fe)
and
copper
(Cu),
essential
transition
metals,
play
pivotal
roles
in
various
cellular
processes
critical
to
cancer
biology,
including
cell
proliferation,
mitochondrial
respiration,
distant
metastases,
oxidative
stress.
The
emergence
of
ferroptosis
cuproptosis
as
distinct
forms
non-apoptotic
death
has
heightened
their
significance,
particularly
connection
with
these
metal
ions.
While
initially
studied
separately,
recent
evidence
underscores
the
interdependence
cuproptosis.
Studies
reveal
a
link
between
accumulation
induction.
This
interconnected
relationship
presents
promising
strategy,
especially
for
addressing
refractory
cancers
marked
by
drug
tolerance.
Harnessing
toxicity
iron
clinical
settings
becomes
crucial.
Simultaneous
targeting
cuproptosis,
exemplified
combination
sorafenib
elesclomol-Cu,
represents
an
intriguing
approach.
Strategies
mitochondria
further
enhance
precision
approaches,
providing
hope
improving
treatment
outcomes
drug-resistant
cancers.
Moreover,
chelators
copper-lowering
agents
established
therapeutic
modalities
exhibits
synergy
that
holds
promise
augmentation
anti-tumor
efficacy
malignancies.
review
elaborates
on
complex
interplay
underlying
mechanisms,
explores
potential
druggable
targets
both
research
settings.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4654 - 4654
Published: April 25, 2024
The
supply
and
control
of
iron
is
essential
for
all
cells
vital
many
physiological
processes.
All
functions
activities
are
expressed
in
conjunction
with
iron-binding
molecules.
For
example,
natural
chelators
such
as
transferrin
chelator–iron
complexes
haem
play
major
roles
metabolism
human
physiology.
Similarly,
the
mainstay
treatments
most
common
diseases
metabolism,
namely
deficiency
anaemia
overload,
involve
iron–chelator
iron-chelating
drugs
deferiprone
(L1),
deferoxamine
(DF)
deferasirox.
Endogenous
citric
acid
glutathione
exogenous
ascorbic
also
important
homeostasis.
Recent
advances
treatment
effective
ferric
tri-maltol
complex
(feraccru
or
accrufer)
transfusional
overload
using
L1
L1/DF
combinations
have
decreased
associated
mortality
morbidity
improved
quality
life
millions
patients.
Many
other
chelating
ciclopirox,
dexrazoxane
EDTA
used
daily
by
patients
diseases.
their
metabolites
iron-chelation
capacity
hydroxyurea,
tetracyclines,
anthracyclines
aspirin,
well
dietary
molecules
gallic
acid,
caffeic
quercetin,
ellagic
maltol
phytochelators,
known
to
interact
affect
related
Different
interactions
observed
presence
essential,
xenobiotic,
diagnostic
theranostic
metal
ions
competing
iron.
Clinical
trials
Parkinson’s,
Alzheimer’s
neurodegenerative
diseases,
HIV
infections,
cancer,
diabetic
nephropathy
inflammation,
highlight
importance
chelation
therapy
clinical
conditions.
proposed
use
modulating
ferroptosis
signifies
a
new
era
design
therapeutic
strategies
introduction
artificial
intelligence
guidance
optimal
outcomes
personalised
medicine
expected
increase
further
impact
medicine,
survival
metabolic
disorders
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1879(4), P. 189124 - 189124
Published: May 25, 2024
Apoptosis
has
traditionally
been
regarded
as
the
desired
cell
death
pathway
activated
by
chemotherapeutic
drugs
due
to
its
controlled
and
non-inflammatory
nature.
However,
recent
discoveries
of
alternative
pathways
have
paved
way
for
immune-stimulatory
treatment
approaches
in
cancer.
Ferroptosis
(dependent
on
iron)
cuproptosis
copper)
hold
promise
selective
cancer
targeting
overcoming
drug
resistance.
Copper
ionophores
iron-bearing
nano-drugs
show
potential
clinical
therapy
single
agents
adjuvant
treatments.
Here
we
review
up-to-date
evidence
involvement
metal
ion-dependent
cytotoxicity
classical
(alkylating
agents,
topoisomerase
inhibitors,
antimetabolites,
mitotic
spindle
inhibitors)
their
combinations
with
ferroptosis
inducers,
indicating
prospects,
advantages,
obstacles
use.
Current Research in Toxicology,
Journal Year:
2024,
Volume and Issue:
7, P. 100181 - 100181
Published: Jan. 1, 2024
Sickle
cell
disease
(SCD)
is
an
inherited
hemoglobin
disorder
marked
by
red
blood
sickling,
resulting
in
severe
anemia,
painful
episodes,
extensive
organ
damage,
and
shortened
life
expectancy.
In
SCD,
increased
iron
levels
can
trigger
ferroptosis,
a
specific
type
of
death
characterized
reactive
oxygen
species
(ROS)
lipid
peroxide
accumulation,
leading
to
damage
impairments.
The
intricate
interplay
between
iron,
inflammation,
oxidative
stress
SCD
underscores
the
necessity
thoroughly
understanding
these
processes
for
development
innovative
therapeutic
strategies.
This
review
highlights
importance
balancing
complex
interactions
among
various
factors
exploitation
knowledge
developing
novel
therapeutics
this
devastating
disease.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(3), P. 392 - 392
Published: Jan. 24, 2025
Hepatocellular
carcinoma
(HCC),
the
most
common
form
of
primary
liver
cancer,
is
rising
in
global
incidence
and
mortality.
Metabolic
dysfunction-associated
steatotic
disease
(MASLD),
one
leading
causes
chronic
disease,
strongly
linked
to
metabolic
conditions
that
can
progress
cirrhosis
HCC.
Iron
overload
(IO),
whether
inherited
or
acquired,
results
abnormal
iron
hepatic
deposition,
significantly
impacting
MASLD
development
progression
While
pathophysiological
connections
between
IO,
MASLD,
HCC
are
not
fully
understood,
dysregulation
glucose
lipid
metabolism
IO-induced
oxidative
stress
being
investigated
as
drivers.
Genomic
analyses
IO
reveal
inconsistencies
association
certain
mutations
with
malignancies.
Moreover,
also
associated
hepcidin
activation
ferroptosis,
representing
promising
targets
for
risk
assessment
therapeutic
intervention.
Understanding
relationship
essential
advancing
clinical
strategies
against
progression,
particularly
recent
IO-targeted
therapies
showing
potential
at
improving
biochemistry
insulin
sensitivity.
In
this
review,
we
summarize
current
evidence
on
HCC,
underscoring
importance
early
diagnosis,
stratification,
targeted
treatment
these
interconnected
conditions.
