New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 29 - 29

Published: Dec. 29, 2024

Epidemiological studies have suggested that following long-term, low-dose daily aspirin (LTLDA) administration for more than 5 years at 75–100 mg/day, 20–30% of patients (50–80 old) had a lower risk developing colorectal cancer (CRC) and about the same proportion in iron deficiency anemia (IDA). In cases IDA, an increase excretion is suspected, which caused by chelating metabolites (ACMs): salicylic acid, salicyluric 2,5-dihydroxybenzoic 2,3-dihydroxybenzoic acid. The ACMs constitute 70% administered dose much longer half-lives blood tissues. mechanisms reduction LTLDA users likely due to ACM’s targeting involved free radical damage, iron-containing toxins, proteins, associated metabolic pathways such as ferroptosis. from non-absorbed (about 30%) may also mitigate toxicity heme nitroso-heme other toxins food, are responsible cause cancer. mode action antioxidant pro-drug ACMs, with continuous presence users, increases prospect prophylaxis diseases. It anticancer effects depend primarily on iron-chelating activity ACMs. role diseases incomplete without considering its rapid biotransformation half-life

Language: Английский

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A Case of Children <i>β</i>-Thalassemia Major Complicated with Liver Cirrhosis and Literature Review

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 325 - 330

Published: Jan. 1, 2024

Language: Английский

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Testosterone and Erythrocyte Lifespan

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract Context Endogenous and exogenous androgens increase circulating erythrocytes hemoglobin but their effects on erythrocyte lifespan is not known. Objective To investigate androgen immature mature in humans mice using novel nonradioactive minimally invasive methods. Design Human was estimated alveolar carbon monoxide concentration blood Levitt's formula hypogonadal or transgender men before up to 18 weeks after commencing testosterone (T) treatment. Erythrocyte receptor knockout wild-type T DHT treatment of intact females orchidectomized males vivo biotin labelling surface epitopes for reticulocytes (Ter119+CD71+) 2 markers (CD45–, Ter119+CD71–) monitoring disappearance rate by flow cytometry. Results Before treatment, had marked reduction compared with controls. increased at 6 returned pretreatment levels weeks, whereas serum were remaining elevated weeks. In mice, higher (but reticulocyte) neither orchidectomy nor inactivation significantly influenced reticulocyte lifespan. Conclusion We conclude that have reduced acute androgen-induced may contribute the well-known erythropoietic androgens, longer term require further investigation determine how much they increases hemoglobin.

Language: Английский

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L-cysteine capped MoS2 QDs for dual-channel imaging and superior Fe3+ ion sensing in biological systems

Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

MoS

Language: Английский

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Comprehensive review of perioperative factors influencing ferroptosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117375 - 117375

Published: Sept. 14, 2024

Language: Английский

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