Ferroptosis in health and disease

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

---

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

---

A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 11, 2025

Language: Английский

---

Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

---

miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation

Toxicology, Journal Year: 2024, Volume and Issue: 503, P. 153742 - 153742

Published: Feb. 6, 2024

Language: Английский

---

Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 7, 2024

Ferroptosis, an iron-dependent form of programmed cell death, introduces a novel perspective on cellular demise. This study investigates the regulatory network exosomal non-coding RNAs (ncRNAs), including miRNAs, circRNAs, and lncRNAs, in ferroptosis modulation. The primary goal is to examine pathological roles ferroptosis-related ncRNAs, particularly ischemic reperfusion injuries. research reveals intricate molecular interactions governing interplay between ncRNAs ferroptosis, elucidating their diverse different non-malignant contexts. Attention given impact diseases, cardiac, cerebral, liver, kidney injuries, as well lung, wound, neuronal Beyond theoretical exploration, provides insights into potential therapeutic applications, emphasizing significance mesenchymal stem cells (MSCs)-derived exosomes. Findings underscore pivotal role MSC-derived modulating responses related regulation, introducing cutting-edge dimension. recognition emphasizes importance exosomes crucial mediators with broad implications. Insights unveil promising avenues for targeted interventions, capitalizing providing comprehensive foundation future strategies.

Language: Английский

---

Novel insights and future perspectives on the nanomedicine-mediated synergistic anticancer effect of the combination of ferroptosis and photothermal therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156921 - 156921

Published: Oct. 1, 2024

Language: Английский

---

CircSCUBE3 promoted ferroptosis to inhibit lung adenocarcinoma progression

Cellular and Molecular Biology, Journal Year: 2024, Volume and Issue: 70(2), P. 161 - 168

Published: Feb. 29, 2024

---

Astragalus mongholicus bunge and panax notoginseng formula (A&P) improves renal fibrosis in UUO mice via inhibiting the long non-coding RNA A330074K22Rik and downregulating ferroptosis signaling

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 19, 2024

Abstract Background Chronic kidney disease (CKD) and its associated end-stage renal (ESRD) are significant health problems that pose a threat to human well-being. Renal fibrosis is common feature ultimate pathological outcome of various CKD leading ESRD. The Astragalus mongholicus Bunge Panax notoginseng formula (A&P) refined compound formulated by our research group, which has been clinically administered for over decade demonstrated the ability improve inflammatory state acute or chronic diseases. However, underlying mechanism A&P ameliorates remains unclear. Methods We established mouse model surgically ligating unilateral ureter induce injury in vivo. And we utilized situ electroporation plasmid with low LncRNA A33 expression establish ureteral obstruction(UUO)mouse model. In vitro, stimulated primary tubular epithelial cells(pTEC) using TGF-β1, siRNA-A33, pcDNA3.1-A33 plasmids were transfected into pTECs respectively knockdown overexpress A33, both vitro vivo models intervened A&P. Results results effectively alleviated mice. Subsequent findings indicated high kidneys UUO mice TGF-β1-induced cells. situ, reduced revealed inhibiting significantly improved Moreover, suppressed downregulation cells resulted numerous fibrotic markers, inhibition notable reduction downstream ferroptosis signaling. Cell experiments downregulating Conclusion Through subsequent signaling, showed potential as therapeutic approach improving mice, providing treatment avenue CKD.

Language: Английский

---

Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117152 - 117152

Published: Dec. 8, 2024

Language: Английский

---