Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28649 - e28649
Published: March 27, 2024
To evaluate the correlation between dry eye symptoms and coronavirus disease 2019 (COVID-19) infection to assess real-time reverse transcription-polymerase chain reaction (RT‒PCR) of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) from conjunctival swab. A prospective observational case series study was conducted all suspected confirmed COVID-19 patients Dr. Cipto Mangunkusumo Hospital (RSCM) Universitas Indonesia (RSUI). On first day visit (day 0), systemic clinical naso-oropharyngeal (NO) RT‒PCR results will classify subjects as non-, suspected, or (mild, moderate, severe) COVID-19. In patients, we determined based on Ocular Surface Disease Index (OSDI) followed up 7(day 7) 14 days 14) after visit. When it technically possible, also examined objective measurements: tear meniscus height (TMH), noninvasive Keratograph® break-up time (NIKBUT), ocular redness. Additionally, took swab samples for SARS-CoV-2 RT-PCR in patients. The OSDI scores 157 decreased across 0, 7, (median (interquartile range): 2.3 (0-8), 0 (0-3), (0-0), p value < 0.0001 (D0 vs D14). moderate-severe group had a higher score than other groups at median D0 (15.6 0-2.3), this pattern consistently seen follow-up D7 D14. However, complaints were not correlated with three measurements mild-moderate NO positive 32 (20.4%) namely, 13 19 mild respectively. Positive observed 7/157 (4.5%) 1 non-COVID-19 6 group. early phase infection, experience symptoms, which have no measurements. can be detected normal-to-mild COVID-19, shows risk transmission.
Language: Английский
Citations
3
Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1306 - 1306
Published: June 27, 2024
Dry eye is a complicated ocular surface disease that causes discomfort, visual disturbance, and frequently observed damage. Emerging hypotheses suggest probiotics may help relieve dry symptoms by modulating inflammation oxidative stress. This study aimed to investigate the therapeutic effects of
Language: Английский
Citations
3
Journal of Neuroimmunology, Journal Year: 2024, Volume and Issue: 395, P. 578433 - 578433
Published: Aug. 14, 2024
Language: Английский
Citations
3
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 30, 2024
Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact oral supplements, varying composition dosage, on symptoms DED. main components these supplements include fish oils (Omega-3 acids), vitamins, trace elements, phytochemical extracts. Beyond well-known nutrients, it necessary explore whether novel nutrients might contribute more management. This review provides comprehensive update therapeutic potential presents new perspectives combination treatment.
Language: Английский
Citations
2
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: July 29, 2024
Thyroid-associated ophthalmopathy (TAO) is an autoimmune-driven orbital inflammatory disease. Despite research efforts, its exact pathogenesis remains unclear. This study aimed to characterize the intestinal flora and metabolic changes in patients with TAO identify metabolites associated disease development.
Language: Английский
Citations
1
Clinical and Experimental Ophthalmology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Abstract Background Glaucoma is the most common cause of irreversible blindness, and gut microbiota (GM) associated with glaucoma. Whether this association represents a causal role remains unknown. This study aims to assess potential link between GM various forms glaucoma, emphasising need for cautious interpretation strength these associations. Methods Employing two‐sample bidirectional Mendelian randomisation (MR) framework false discovery rate correction sensitivity analyses, supplemented by genetic correlation analysis via linkage disequilibrium score regression (LDSC) colocalisation European summary‐level data MiBioGen consortium FinnGen Study, we sought explore relationship Results While certain microbial taxa showed associations glaucoma subtypes (e.g., Erysipelotrichaceae primary angle closure Senegalimassilia exfoliation glaucoma), overall findings suggest complex not definitively Notably, reverse MR did establish significant effect on composition, no consistent correlations were observed Conclusions our provides some evidence specific results underscore complexity relationships further research clarify links. The highlight importance interpreting gut‐eye axis caution that while may play in it unlikely be predominant factor.
Language: Английский
Citations
1
Bioengineering, Journal Year: 2024, Volume and Issue: 11(11), P. 1063 - 1063
Published: Oct. 24, 2024
The relationship between gut microbiota and glaucoma has garnered significant interest, with emerging evidence suggesting that dysbiosis, inflammation, immune mechanisms may contribute to pathogenesis. Understanding these interactions through the gut-retina axis offers new insights into disease progression potential therapeutic options. This study combines bibliometric analysis literature review evaluate research trends key areas related microbiota's role in glaucoma. Our data were collected from Web of Science Core Collection (WoSCC) included English original articles reviews published 1 January 2008, 6 August 2024. Visual statistical analyses conducted using VOSviewer CiteSpace. comprised 810 citations leading journals, representing contributions 23 countries/regions, 111 institutions, 40 321 authors. Among countries regions involved, USA China contributors, publishing most being major hubs.
Language: Английский
Citations
1
American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
1
Ocular Immunology and Inflammation, Journal Year: 2024, Volume and Issue: 32(9), P. 1973 - 1982
Published: Feb. 9, 2024
Purpose To evaluate the anti-inflammatory activity of a cell-free supernatant from Lactiplantibacillus plantarum CRL 759, in phosphate buffer modified according to Sorensen called POF-759.
Language: Английский
Citations
0
Russian Ophthalmological Journal, Journal Year: 2024, Volume and Issue: 17(2), P. 148 - 153
Published: July 2, 2024
Nowadays, glaucoma is viewed as a multifactorial neurodegenerative condition that involves many factors affecting different cell types in human body. As known, increased intraocular pressure (IOP) not the only threatening factor of ganglion apoptosis and glaucomatous optic neuropathy development; IOP can be associated with other factors, such vascular, metabolic, neurotrophic, immune, inflammatory, etc. However, treatment remains largely symptomatic, aimed almost exclusively at reducing IOP. Microbiotic dysbiosis newly developing research direction progress, showing this mechanism may turn out to an important development. There are reasons believe strategies microbiota damage correction contribute better efficiency management.
Language: Английский
Citations
0