Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116306 - 116306
Published: May 22, 2024
Language: Английский
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1147 - 1160
Published: Feb. 1, 2024
Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature the form VK1 VK2.As its initial recognition originated from ability to promote blood coagulation, it is known as coagulation vitamin.However, based on extensive research, VK has shown potential for prevention treatment various diseases.Studies demonstrating beneficial effects immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, bone protection have drawn growing interest recent years.This review article focuses mechanism action preventive therapeutic infections (eg, asthma, COVID-19), inflammation type 2 diabetes mellitus, Alzheimer's disease, Parkinson's cancer, aging, atherosclerosis) autoimmune disorders inflammatory bowel 1 multiple sclerosis, rheumatoid arthritis).In addition, VK-dependent proteins (VKDPs) are another crucial by which exerts anti-inflammatory immunomodulatory effects.This explores role preventing combating neurological abnormalities, treating diseases such cancer diabetes.Although current research appoints tool practical clinical applications infections, inflammation, diseases, future necessary elucidate more detail overcome limitations.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 753 - 753
Published: Jan. 17, 2025
Type 2 diabetes mellitus (T2DM) is one of the most widespread chronic diseases globally, with its prevalence expected to rise significantly in years ahead. Previous studies on risk stratification for T2DM identify certain biomarkers, including glycated hemoglobin (HbA1c), oral glucose tolerance testing (OGTT), fructosamine, and albumin, as key indicators predicting onset progression T2DM. However, these traditional markers have been shown lack sensitivity specificity their results are difficult analyze due non-standardized interpretation criteria, posing significant challenges an accurate definitive diagnosis. The strict measures may not catch gradual increases blood sugar levels during early stages evolution, might still fall within acceptable glycemic parameters. Recent advancements research suggested novel micro ribonucleic acid (miRNA) circulatory molecules that can facilitate detection prediabetic conditions high-risk groups potentially enable prevention This capability makes them a very powerful tool improving population health, enhancing outcomes many patients, reducing overall burden These promising biomarkers small, noncoding RNA involved regulation cellular functions hand metabolic activities cells, making useful relevant biomarker explore diagnosis review analyzes current literature, outlining occurrence miRNAs diabetic individuals implications dysglycemic disorders.
Language: Английский
Citations
1
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 146, P. 107277 - 107277
Published: March 12, 2024
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 258, P. 128873 - 128873
Published: Dec. 21, 2023
Language: Английский
Citations
14
Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 14, 2024
Language: Английский
Citations
5
Journal of Biomolecular Structure and Dynamics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15
Published: March 14, 2025
Barnyard millet (Echinochloa frumentacea) is a nutritionally superior grain and rich source of dietary fiber, protein. It helps in managing health issues such as malnutrition, diabetes, obesity, celiac disease. Its low content slowly digestible carbohydrates promotes gradual release glucose, helping to maintain stable blood glucose levels. The present study aims identify screen phytochemicals the barnyard explore its anti-diabetic activity through an in-silico study. Gas chromatography-mass spectrometry (GC-MS) analyses seed extract revealed occurrence 73 bioactive compounds that are known possess variety pharmacological activities. Based on virtual screening analysis, interacted with five different diabetic targets, diosgenin demonstrating lowest binding affinity across four receptors. Specifically, showed -9.2 kcal/mol Insulin receptor (PDB ID: 1IR3), -8.7 Peroxisome proliferator-activated receptors 3G9E), -7.5 Tyrosine phosphatase 1-beta (2F70), -6.5 Glucagon 5EE7). For Aldose reductase 4XZH), Docosahexaenoic acid exhibited -9.9 kcal/mol. dynamic behavior 2F70-Diosgenin docked complexes throughout 500 ns trajectory run was investigated further. RMSD RMSF reveal complex remains structurally stable. free energies were computed using Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA) methodology. calculation results show predicted These suggest stable, highlighting potential for further wet lab validation.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: March 19, 2025
The gut microbiota is closely associated with the onset and development of type 2 diabetes mellitus (T2DM), characterized by insulin resistance (IR) chronic low-grade inflammation. However, despite widespread use first-line antidiabetic drugs, IR in its complications continue to rise. metabolic products may promote T2DM exacerbating IR. Therefore, regulating has become a promising therapeutic strategy, particular attention given probiotics, prebiotics, synbiotics, fecal transplantation. This review first examines relationship between T2DM, summarizing research progress microbiota-based therapies modulating We then delve into how microbiota-related contribute Finally, we summarize findings on role traditional Chinese medicine improve In conclusion, play crucial pathophysiological process IR, offering new insights potential strategies for T2DM.
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: March 27, 2025
Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos OA T2DM, mechanisms MSC-Exos, therapeutic strategies engineered exosomes. Although MSC-Exo therapy shows promising potential, further research is needed validate its safety feasibility.
Language: Английский
Citations
0
Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101895 - 101895
Published: Jan. 18, 2025
Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, satiety. We examine compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) managing type 2 diabetes (T2D), obesity, other The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated (MAPK), C (PKC). Expanding our understanding, investigates potential role cancers. Also, microribonucleic acid (RNA) (miRNAs), critical regulators gene expression, introduced modulators signaling. delve link between miRNAs T2D obesity explore specific miRNA examples influencing GLP-1R function. Finally, explores rationale seeking alternatives to highlights natural products modulatory effects.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0318134 - e0318134
Published: Jan. 27, 2025
Objectives This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within P2X7 gene on susceptibility type 2 diabetes mellitus (T2DM) and evaluate their association with diabetic complications. Methods is comprised 200 T2DM cases healthy controls. Seven candidate SNP loci were screened, TaqMan-MGB real-time PCR technology was used determine polymorphic variants P2X7. Different genotype allele frequencies compared by Pearson’s χ2 tests logistic regression analysis. Results Three SNPs found be associated risk. Specifically, rs7958311 GA (OR = 1.323, p 0.002), AA 1.508, 0.038), rs208294 CC 1.854, 0.042) showed a higher T2DM, whilst rs11065464 CA 0.614, 0.022) reduced Logistic analysis indicated that linked an increased risk for nephropathy 1.833, 0.022), but decreased peripheral artery disease 0.550, 0.042). Additionally, identified as factor neuropathy 2.101, 0.016). Conclusions We are significantly its complications, suggesting targeting may offer novel therapeutic strategy prevention personal treatment T2DM.
Language: Английский
Citations
0