Relationship Between Novel Inflammatory Indices and the Incidence of Postoperative Pneumonia After Endovascular Embolization for Aneurysmal Subarachnoid Hemorrhage

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 667 - 679

Published: Jan. 1, 2025

Accurate identification of the risk postoperative pneumonia (POP) in aneurysmal subarachnoid hemorrhage (aSAH) is essential for implementation stratified treatment. This study evaluated relevance and utility Systemic Immuno-inflammatory Index (SII) Inflammatory Response (SIRI) predicting after aSAH. Two hundred forty patients undergoing aSAH intervention were included. Differences SII SIRI between patient groups analyzed by propensity score matching (PSM). Receiver Operating Characteristic curves (ROC) used to evaluate predictive validity determine their thresholds. The association these indices with POP was assessed multivariate logistic regression restricted cubic spline (RCS), subgroup analyses performed. overall prevalence 60%, 37.5% males 62.5% females. PSM showed statistically significant differences two (P=0.032) (P=0.02). They had a high accuracy POP, AUC values 0.643 0.644, respectively. positively associated risk, independent other confounders. Moreover, further sensitivity analysis RCS supported stability this finding. Subgroup that relationship stable across subgroups. reveals potential role aSAH, provides strong basis early stratification who are at

Language: Английский

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Oxidative Stress in Sepsis: A Focus on Cardiac Pathology

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2912 - 2912

Published: March 2, 2024

This study aims to analyze post-mortem human cardiac specimens, verify and evaluate the existence or extent of oxidative stress in subjects whose cause death has been traced sepsis, through immunohistological oxidative/nitrosative markers. Indeed, present study, i-NOS, NOX2, nitrotyrosine markers were higher expressed septic group when compared control group, associated with also a significant increase 8-OHdG, highlighting pivotal role etiopathogenesis. In particular, 70% cardiomyocyte nuclei from specimens showed positivity for 8-OHdG. Furthermore, intense massive NOX2-positive myocyte immunoreaction was noticed as immunostaining reaction found cells. These results demonstrated correlation between nitrosative imbalance pathophysiology dysfunction documented cases sepsis. Therefore, subsequent studies will focus on expression other organs tissues, well involvement intracellular pattern apoptosis, better clarify complex pathogenesis multi-organ failure, leading support rationale including therapies targeting redox abnormalities management patients.

Language: Английский

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Recent Advances in Pathogenesis and Anticoagulation Treatment of Sepsis-Induced Coagulopathy

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 737 - 750

Published: Jan. 1, 2025

Coagulopathy in sepsis is common and associated with high mortality. Although immunothrombosis necessary for infection control, excessive thrombus formation can trigger a systemic thrombo-inflammatory response. Immunothrombosis plays core role sepsis-induced coagulopathy, research has revealed complex interplay between inflammation coagulation. Different mechanisms underlying sepsis-related coagulopathy are discussed, including factors contributing to the imbalance of pro- anticoagulation relevant endothelial cells. The potential therapeutic implications anticoagulants on these discussed. This review contributes our understanding pathogenesis patients sepsis. Recent studies suggest that cells play an important immunoregulation hemostasis. Meanwhile, non-anticoagulation effects anticoagulants, especially heparin, which act septic patients, have been partially revealed. We believe further insights into will help physicians evaluate patient conditions effectively, leading advanced early recognition better decision-making treatment

Language: Английский

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Development and Validation of a Nosocomial Infection Nomogram Model in the NICU: A Novel and Nurse-Led Way to Prediction in Preterm Infants

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 589 - 599

Published: Jan. 1, 2025

Nosocomial infections (NI) are a leading cause of mortality in preterm infants the Neonatal Intensive Care Unit (NICU). The key to reducing risk NI is early detection and treatment time. Nurses close observers primary caregivers for neonates at bedside NICU, who best positioned capture signals NI. This study aims develop nurse-led prediction model NICU. was designed as retrospective study, NICU Renmin Hospital Wuhan University from January 2020 December 2023 were selected divided into group non-NI group. Clinical data collected then analyzed by univariate analysis, least absolute shrinkage selection operator (LASSO) regression multivariate logistic analysis. outcome constructed nomogram its predictive efficacy evaluated area under receiver operating characteristic curve (AUC), calibration curve, decision analysis (DCA). Bootstrap method used repeat 1,000 times internal validation. A total 892 finally included established, which six variables: skin color changes, respiratory related feeding deterioration, birth weight, number arterial venous blood draws, days nasogastric tube placement. model's AUC 0.953, indicating good discriminatory power. plot demonstrated Hosmer-Lemeshow test showed high consistency. DCA indicated that had clinical utility. Internal validation 0.952. model, mainly based on nurses' observations, shows ability. It offered more convenient option neonatologists nurses

Language: Английский

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Relationship between the geriatric nutritional risk index and sepsis in elderly critically ill patients: a retrospective cohort study

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 24, 2025

To investigate the relationship between geriatric nutritional risk index (GNRI) and sepsis in elderly critically ill patients. We extracted data from MIMIC-IV database for patients aged 65 older who were first-time admissions to Intensive Care Unit. The GNRI, derived serum albumin, height, weight, served as exposure variable. main outcome was occurrence of sepsis. utilized multivariable logistic regression evaluate association GNRI Additionally, we employed restricted cubic splines potential nonlinear incidence study included 3,535 patients, with 2,005 (56.7%) developing Septic had significantly lower values (median: 99 vs. 101, P = 0.021) a higher prevalence malnutrition (GNRI ≤ 98) (47.5% 43.5%, 0.018). analysis employing identified U-shaped (P non-linearity 0.004), an inflection point at 105.4. left this point, negatively associated (OR 0.987, 95% CI 0.978—0.996, 0.005), while right side showed positive correlation 1.011, 1.000—1.022, 0.044). reveals Both low high are increased risk, turning These findings highlight GNRI's utility screening tool identifying ICU

Language: Английский

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Multimodal monitoring of neutrophil activity during cardiac surgery

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Cardiac surgery and the associated ischemia-reperfusion injury trigger an inflammatory response, which, in turn, can contribute to organ damage, prolonged hospitalization, mortality. Therefore, present study performed comprehensive monitoring of neutrophil-related inflammation patients who underwent aortic valve surgery, including extracorporeal circulation. Neutrophil-related inflammation, as well alterations cellular physiology, phenotype, function, were analyzed by flow cytometry, ELISA, microscopy. Neutrophil activation occurred intraoperatively preceded upregulation conventional markers such C-reactive protein interleukin-6. Perioperatively, neutrophils maintained a stable response platelet-activating factor (PAF) with regard CD11b CD66b expression but showed decreased CD10. Postoperatively, exhibited marked PAF-induced depolarization, while reactive oxygen species generation phagocytic activity remained largely stable. Surprisingly, platelet-neutrophil complex formation was severely impaired returned normal levels postoperatively. Further studies are needed elucidate implications these intraoperative postoperative changes neutrophil platelet respect potential immune dysfunction that temporarily increases susceptibility infectious or hemostatic complications.

Language: Английский

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The prevalence and risk factors of gouty arthritis among fishermen in the Niger Delta region of Nigeria

Exploration of Musculoskeletal Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Aim: This study aimed to explore the prevalence and risk factors of gout among fishermen in Niger Delta. Methods: A total 300 fishermen, aged 25–65 years, were recruited through stratified sampling. Data on demographic characteristics, seafood alcohol consumption, physical activity, obesity, family history collected using structured questionnaires clinical assessments. Logistic regression analysis was applied identify significant predictors gout. Results: The found that 27%, with highest occurrence participants 46–55 years. Significant included high intake (OR = 3.2, P < 0.01), consumption 2.8, obesity 1.9, 0.03), inactivity 1.7, 0.04), (OR: 1.5, 0.05). Seafood identified as most predictor Conclusions: revealed a Delta, intake, major contributors. Targeted public health interventions, such dietary education programs, campaigns reduce initiatives promote regular screenings, are essential mitigate impact fishermen.

Language: Английский

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Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3259 - 3259

Published: April 1, 2025

This article explores systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses neonates, offering a comprehensive examination of their pathophysiology, diagnostic criteria, clinical implications. It identifies SIRS as an exaggerated to external stress, disrupting the balance between inflammation adaptive mechanisms, driven by cytokines such TNF-α IL-1. The fetal (FIRS), subset SIRS, is noted for its role adverse neonatal outcomes, including organ damage, inflammation, long-term developmental disorders. discusses extensive effects FIRS on critical systems, blood, lungs, central nervous system, kidneys. highlights challenges diagnosing managing focusing relationship hemostatic system. Additionally, paper points out recent advancements, convergent model coagulation emerging biomarkers like microRNAs early detection. Despite this progress, gaps remain understanding molecular mechanisms underlying these conditions developing effective therapeutic strategies. necessity targeted research mitigate morbidity mortality associated with neonates.

Language: Английский

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The Impact of Intraoperative Respiratory Patterns on Morbidity and Mortality in Patients with COPD Undergoing Elective Surgery

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2438 - 2438

Published: April 3, 2025

Background/Objectives: Surgical procedures in chronic obstructive pulmonary disease (COPD) patients carry a high risk of postoperative respiratory failure, often causing the need for mechanical ventilation and prolonged intensive care unit (ICU) stays. Accompanying COPD with heart failure further increases complications. This study aimed to identify predictors mortality, ICU hospital stays, ventilation, vasoactive drug usage moderate severe undergoing elective non-cardiac surgery. Methods: retrospective cohort analyzed eICU-CRD data, including adult admitted from operating room following Spearman's correlation analysis was performed assess associations between intraoperative parameters ICU/hospital length stay, laboratory parameters, their perioperative dynamics. Results: included 680 (21% COPD). Hospital mortality were 8.6% 4.4%, respectively. Median stays 1.9 6.6 days, Intraoperative tidal volume, expired minute positive end-expiratory pressure, mean airway peak inspiratory compliance had no statistically significant association its duration, or use vasopressors/inotropes. Tidal volume correlated positively changes monocyte count (R = 0.611; p 0.016), lymphocytes 0.327; 0.017), neutrophil 0.332; 0.02). Plateau pressure showed strong neutrophil-to-lymphocyte ratio 0.708; 0.001). Conclusions: modes appear have impact on outcomes markers, except possibly ratio, although elevation cause remains unclear.

Language: Английский

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Neutralization of IL‐17 and CXCR1 Protects Septic Arthritis by Regulating CXCL8‐CXCR1 Pathway Along With Functional Activities in Neutrophils

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(4)

Published: April 1, 2025

ABSTRACT Aim The main objective of this study is to elucidate the role CXCR1 Ab, IL‐17 and gentamicin in protecting septic arthritis by regulating neutrophil functional responses while evaluating contribution CXCL8‐CXCR1 pathway. Methods Eighty‐four experimental swiss albino mice were utilized arthritis. They divided into eight groups. After developing sepsis, respective groups treated with doses. Doses administered on days 1, 8, 13 schedule. At early, middle, late phases experiment i.e. at 3, 10, 15 DPI (Days Post Infection), sacrificed blood tissues collected for further evaluations. Different studies performed isolated neutrophils, spleen, synovial tissues. Histological evaluation, immunofluorescence study, sepsis profile, downstream signaling pathway analysis done obtain data. Results Infected group exhibited high inflammatory treatment helped mitigate them. neutralization lower bacterial burden, ROS activity, MPO ALP activity. However, combined greatly influenced PMN chemotactic activity lysozyme early phase experiment, neutralization's impact was more prominent, later, gained upper hand. Conclusions We can conclude that Ab combination potent modulating activities positively cure through CXCL8/CXCR1 pathway, regulates impacting different cascades.

Language: Английский

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