Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance DOI Creative Commons
Lorenzo Del Moro, Elenamaria Pirovano, Eugenia Rota

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Brain insulin resistance has recently been described as a metabolic abnormality of brain glucose homeostasis that proven to downregulate receptors, both in astrocytes and neurons, triggering reduction uptake glycogen synthesis. This condition may generate mismatch between brain's energy reserve expenditure, mainly during high demand, which could be involved the chronification migraine and, long run, at least certain subsets patients, prodromic phase Alzheimer's disease, along putative physiopathological continuum. Indeed, persistent disruption supply neurons eventually impair protein folding, an energy-requiring process, promoting pathological changes such amyloid-β deposition tau hyperphosphorylation. Hopefully, "neuroenergetic hypothesis" presented herein will provide further insight on there being conceivable bridge chronic elucidating novel potential targets for prophylactic treatment diseases.

Language: Английский

Oxidative stress–mediated neuroinflammation in Alzheimer’s disease DOI

Sayed Mohammed Firdous,

Sahabaj Ali Khan, Amritangshu Maity

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Language: Английский

Citations

14
A new frontier in neuropharmacology: Recent progress in natural products research for blood–brain barrier crossing DOI Creative Commons

Ureña-Vacas Isabel,

Aznar de la Riera M. Belén,

Serrano Dolores R

et al.

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 8, P. 100235 - 100235

Published: Jan. 1, 2024

Neuropharmacology faces challenges due to the intricate nervous system, diverse neurological disorders, and existence of blood–brain barrier (BBB), which hinder development effective treatments. Although primary function BBB is expel toxins pathogens, this structure also prevents optimal drug delivery. Natural products, with their chemical diversity sustainability, have long been recognized as potential neuroprotective compounds, making permeability studies mandatory. Over last ten years, biotechnological advances in two-dimensional vitro models (monoculture co-culture), vivo imaging techniques, pharmacokinetic modeling contributed expanding our current knowledge. In study, we reviewed crossing natural products such different terpenoids, polyphenolic alkaloids. The findings, obtained through vitro, vivo, silico methods, revealed moderate high for many these products. However, other compounds showed not be able reach brain. To better understand behavior humans improve ability pass across blood-brainier, new three-dimensional dynamic BBB, nanosystems complexes encapsulation or in-depth transport mechanism are future lines research.

Language: Английский

Citations

8
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis) DOI
Nahuel Ezequiel Wanionok,

Gustavo R Morel,

Juan Manuel Fernández

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102408 - 102408

Published: July 3, 2024

Language: Английский

Citations

5
α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke DOI Creative Commons
José Marco‐Contelles

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 440 - 440

Published: April 7, 2024

The recent advances in research on the use of antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for therapy stroke have been reviewed. protective effect PBN transient occlusion middle cerebral artery (MCAO) has demonstrated, although there significant differences neuronal salvaging between PBN-treated untreated animals, each set data having quite large inter-experimental variation. In forebrain ischemia model gerbil, reduces mortality after damage hippocampal cornu ammonis 1 (CA1) area hippocumpus caused by ischemia. However, fails to prevent postischemic CA1 rat. As focal ischemia, significantly infarction decreases neurological deficit using a rat persistent MCAO rats. Similarly, capacity number PBN-derived nitrones prepared author’s laboratory also summarized here, showing their high potential therapeutic power treat stroke.

Language: Английский

Citations

4
Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis DOI

Nelson Arroyo-Pacheco,

Shayuri Sarmiento-Blanco,

Guillermo Vergara-Cadavid

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102620 - 102620

Published: Dec. 1, 2024

Language: Английский

Citations

4
Targeting Lkb1-Ampk-Sirt1-Induced Autophagy and Mitophagy Pathways Improve Cerebrovascular Homeostasis in App/Ps1 Mice DOI
Yawen Li, Yifan Wu, Tongxing Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effects of a Loosening Meditation Practice on Older Adults With Mild Cognitive Impairment: A Pilot Study DOI Open Access
Yoshinori Kajimoto, Shinobu Tamura,

Kosuke KAWAMURA

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Background Holistic medical practices, including meditation and mindfulness, are increasingly recognized for their benefits in mental health stress reduction, with applications clinical settings. However, effects on older adults mild cognitive impairment (MCI) remain underexplored. This study aimed to evaluate the impact of loosening meditation, a brief accessible practice we developed, this population. Methods Nine MCI, defined by Mini-Mental State Examination (MMSE) scores 21-28 during screening period, participated pilot study. The sessions our were conducted weekly over four weeks. Cognitive function was assessed using MMSE Revised Hasegawa's Dementia Scale (HDS-R), while psychological well-being evaluated 30-item General Health Questionnaire (GHQ-30) Japanese version University Wales Institute Science Technology Mood Adjective Checklist (JUMACL). Serum levels representative biomarkers measured before after first session. Results Participants had mean age 78.1 years (± 4.8 years) score 25.1 points 2.5). These participants could complete all safely. No significant differences observed MMSE, HDS-R, GHQ-30, or JUMACL (tension arousal) intervention. (emotion significantly improved fourth session (pre-first, 25.3 ± 6.2; post-fourth, 28.7 7.3; p = 0.004). Among these biomarkers, serum cortisol decreased following (before versus after, 10.8 5.8 7.4 2.3 μg/dl; 0.04). Additionally, although not statistically significant, there trend towards lower level adrenaline 0.057 0.026 0.050 0.027 ng/ml; 0.06). Conclusions Our feasible, acceptable, safe, might enhance mood reduce even MCI. preliminary findings suggest its potential as supportive intervention

Language: Английский

Citations

0
Expression of Neuronal Nicotinic Acetylcholine Receptor and Early Oxidative DNA Damage in Aging Rat Brain—The Effects of Memantine DOI Open Access
Małgorzata Lewandowska, Agata Różycka, Teresa Grzelak

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1634 - 1634

Published: Feb. 14, 2025

Aging and age-related neurodegenerative disorders are characterized by the dysfunction or loss of brain nicotinic acetylcholine receptors (nAChRs), these changes may be related to other senescence markers, such as oxidative stress DNA repair dysfunction. However, mechanism nAChR in aging modification this process drugs (e.g., memantine, Mem) not yet fully understood. To study whether differences expression rat occur due modulated Mem, we analyzed subunits (at RNA protein levels) biomarkers real-time quantitative polymerase chain reaction (RQ-PCR) Western blot validation. Twenty-one female Wistar rats were divided into four groups, depending on age, oldest group received injections Mem water with use intragastric catheters. We studied cerebral grey matter (CGM), subcortical white (SCWM), cerebellum (Ce). Results showed an decrease α7 mRNA level SCWM. The was accompanied reduced 8-oxoguanine glycosylase 1 (OGG1) increased tumor necrosis factor alpha (TNFα) level. In group, observed a higher SCWM Ce. Biomarker levels changed, but different extent area. Importantly, antioxidative status stopped even regressed under treatment. After two weeks treatment, increase TP53 8-oxo-2'deoxyguanosine (8-oxo-2'dG) observed. conclude that administration protective against mechanisms.

Language: Английский

Citations

0
Promising Natural Remedies for Alzheimer’s Disease Therapy DOI Creative Commons

Amin Mahmood Thawabteh,

Aseel Wasel Ghanem, Sara AbuMadi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 922 - 922

Published: Feb. 17, 2025

This study examines the intricacies of Alzheimer's disease (AD), its origins, and potential advantages various herbal extracts natural compounds for enhancing memory cognitive performance. Future studies into AD treatments are encouraged by review's demonstration effectiveness phytoconstituents that were extracted from a number plants. In addition to having many beneficial effects, such as improved cholinergic function, medicines also much less harmful, more readily available, easier use than other treatments. They pass without difficulty through blood-brain barrier (BBB). focused on substances their effects using academic databases identify peer-reviewed published between 2015 2024. According literature review, 66 isolated 21 distinct plants have shown efficacy, which could be encouraging future research therapies. Since most clinical trials produce contradictory results, suggests larger-scale with longer treatment durations necessary validate or refute therapeutic efficacy

Language: Английский

Citations

0
Sequential Proteomic Analysis Reveals the Key APOE4‐Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice DOI Creative Commons

Pengju Wei,

Kaihua Lin,

Xuhui Chen

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

Alzheimer's disease (AD) involves a prolonged presymptomatic or preclinical stage with subtle pathological changes. Apolipoprotein E4 (APOE4) is significant genetic risk factor for AD, yet its specific role at the not fully understood. This study aimed to elucidate cellular and molecular effects of APOE4 compared APOE3 on AD progression during stage. We generated 5xFAD mice carrying human their non-AD controls. Behavioral tests, immunostaining, quantitative proteomics phosphoproteomics, Golgi staining, Western blotting were conducted 3 10 months age, respectively. Cell culture experiments performed assess APOE4's direct impact neuronal mitochondrial function. significantly increased β-amyloid (Aβ) deposition microglial activation in stage, without aggravating blood-brain barrier disruption. Proteomic biochemical analysis revealed strong features synaptic degeneration dysfunction associated APOE4. Notably, promoted fusion mitophagy while inhibiting fission, leading impaired energy supply reactive oxygen species. Our findings indicate that accelerates pathologies by exacerbating Aβ deposition, neuroinflammation, degeneration. The highlights as critical mediator APOE4-induced progression, providing potential targets early intervention.

Language: Английский

Citations

0