Amygdalin as a Potential Anti-Cancer Agent: A Concise Review of Therapeutic Insights and Mechanisms DOI Creative Commons
Raghad F. Al-Ansari, Khalid Zainulabdeen,

Maryam Hamed Jabir

et al.

Baghdad Journal of Biochemistry and Applied Biological Sciences, Journal Year: 2024, Volume and Issue: 5(4), P. 255 - 265

Published: Dec. 30, 2024

Amygdalin, also known as laetrile, has generated significant controversy within the scientific medical community regarding its efficacy a cancer treatment. Extracted primarily from seeds of fruits like apricots and almonds, it been promoted by certain groups potential cure for despite criticism toxicity minimal therapeutic value. This review aims to analyze available literature on amygdalin, focusing chemical characteristics, proposed mechanisms action, role in prevention therapy. A comprehensive preclinical data clinical trials was conducted assess amygdalin's effects associated risks. The analysis existing studies provides insights into complexity biological activity, including interactions suggested pathways treatment, while highlighting need further research clarify safety. Ultimately, contributes ongoing discussion surrounding position oncology emphasizes necessity continued exploration develop effective treatment strategies.

Language: Английский

Evaluating the Therapeutic Potential of Amygdalin: Cytotoxic and Antimicrobial Properties DOI

Doaa R.I. Abdel-Gawad,

Marwa Ibrahim, Hossny A. El-Banna

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 89, P. 102443 - 102443

Published: June 12, 2024

Language: Английский

Citations

5
Anticancer Attributes and Multifaceted Pharmacological Implications of Laetrile and Amygdalin DOI Open Access
Katya Carbone, Oksana Sytar, Farukh Sharopov

et al.

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Laetrile, known as vitamin B17, is often used interchangeably with amygdalin. Laetrile a semi‐synthesis product of amygdalin, whereas amygdalin naturally occurring substance in many plants. Both compounds have nitrile functional group that, when activated by the intestinal enzyme β‐glucosidases, releases hydrogen cyanide. The two been considered for long time alternative therapy cancer treatment however, findings available literature are discordant on real efficacy laetrile/amygdalin cancer, highlighting negative benefit‐risk ratio. In this regard, study aimed to comprehensively analyze scientific data laetrile/amygdalin, special emphasis their pharmacokinetics, underlying pharmacological properties, mode action potent antitumor agent, and effect human health. results showed that there no clear evidence following administration, especially at clinical trial level. However, vitro studies biological activity these positive effects related antifibrotic, anti‐inflammatory, antiasthmatic, immunoregulatory processes. Laetrile's mechanism closely resembles affecting signaling pathways. due its cyanide toxicity, it was banned food drug administration (FDA) safety concerns. Despite not receiving permission from FDA, laetrile emerged an 1970s. Nonetheless, continuing research investigating safer methods activating targeted treatment. This opens interesting prospects using medical therapies, which, further needed.

Language: Английский

Citations

0
The active components and potential mechanisms of Li-Chong-Xiao-Zhen granules in the treatment of ovarian cancer: An integrated metabolomics, proteomics, network pharmacology and experimental validation DOI Creative Commons
Yiliu Chen, Rina Su, Guilin Hu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119474 - 119474

Published: Feb. 1, 2025

Language: Английский

Citations

0
Combined metabolomics and bioactivity assays kernelby-productsof two native Chinese cherry species: The sources of bioactive nutraceutical compounds DOI Creative Commons
Ziwei Wang,

Lin Li,

Jiaqi Han

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101625 - 101625

Published: July 5, 2024

Cherry kernels are a by-product of cherries that usually discarded, leading to waste and pollution. In this study, the chemical composition 21 batches cherry from two different species was analyzed using untargeted metabolomics. The in vitro antioxidant activity, cellular antiproliferative activity these kernel extracts were also determined, correlation analysis conducted between differential compounds biological activity. A total 49 screened.

Language: Английский

Citations

2
Survey of Physicians and Healers Using Amygdalin to Treat Cancer Patients DOI Open Access

Sascha D. Markowitsch,

Sali Binali,

Jochen Rutz

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2068 - 2068

Published: June 28, 2024

Amygdalin is purported to exhibit anti-cancer properties when hydrolyzed hydrogen cyanide (HCN). However, knowledge about amygdalin efficacy limited. A questionnaire evaluating the efficacy, treatment, and dosing protocols, reasons for use, HCN levels, toxicity was distributed physicians healers in Germany, providing as an drug. Physicians (20) (18) provided over 8 (average) years nearly 80 annually treated patients/providers. Information predominantly obtained from colleagues (55%). administered both intravenously (100%) orally (32%). Intravenous application considered maximally delay disease progression (90%) relieve symptoms Dosing based on recommendations (71%) or personal experience (47%). If limited success became apparent after initial 3g/infusion, infusions were increased 27g/infusion. Treatment response primarily monitored with established (26%) non-established tumor markers (19%). 90% did not monitor levels. Negative effects restricted a few dizzy spells nausea. Only 58% willing participate clinical trials contribute data analysis (34%). are commonly by side effects. The absence of standardized treatment calls guidelines. Since intravenous bypasses metabolization, re-evaluation its mode action required.

Language: Английский

Citations

1
Online identification of potential antioxidant components and evaluation of DNA oxidative damage protection ability in Prunus persica flowers DOI
Mimi Sun, Xinyu Lei, Xin Lan

et al.

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126702 - 126702

Published: Aug. 13, 2024

Language: Английский

Citations

1
Growth of Renal Cancer Cell Lines Is Strongly Inhibited by Synergistic Activity of Low-Dosed Amygdalin and Sulforaphane DOI Open Access

Sascha D. Markowitsch,

Thao Pham,

Jochen Rutz

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3750 - 3750

Published: Oct. 31, 2024

: Plant derived isolated compounds or extracts enjoy great popularity among cancer patients, although knowledge about their mode of action is unclear. The present study investigated whether the combination two herbal drugs, cyanogenic diglucoside amygdalin and isothiocyanate sulforaphane (SFN), influences growth proliferation renal cell carcinoma (RCC) lines.

Language: Английский

Citations

0
Quality attributes and antioxidant activity of stirred yoghurt fortified with some nano-fruit waste powders DOI Creative Commons
S. Taha, Fouad M. F. Elshaghabee, Mostafa A. Ameen

et al.

Discover Food, Journal Year: 2024, Volume and Issue: 4(1)

Published: Oct. 31, 2024

Abstract Agro-industrial wastes have emerged as a significant source of bioactive compounds. Therefore, this study was conducted to evaluate the feasibility using nano-powders some fruit wastes, namely; apricot ( Prunus sp.) and peach persica L. Batsch) kernels, watermelon Citrullus lanatus ) rind banana Musa spp.) peel functional ingredients (0.5%) in stirred yoghurt, well their effect on antioxidant activity, quality characteristics, viability yoghurt starter culture sensory attributes. Results revealed that fortification process significantly P < 0.05) elevated total solids, fat, protein ash contents, especially with kernels (AK PK), which distinctly increased fat by average values 3.46 3.40%, 3.70 3.68% during storage compared control (3.12 3.57%), respectively. The addition (WMR) titratable acidity (0.97%) viscosity (463.59 cP) reduction syneresis (16.38%), viable count culture, acetaldehyde diacetyl contents (167.10 18.82 mg/100 g) followed (BP). Stirred fortified BP nano-powder had highest phenolic content (20.96 mg gallic acid/g) DPPH scavenging activity (31.93%) other nano-fruit wastes. Sensory attributes were improved WMR periods, those AK PK. All studied constitute excellent raw materials for development novel yoghurt.

Language: Английский

Citations

0
Amygdalin as a Potential Anti-Cancer Agent: A Concise Review of Therapeutic Insights and Mechanisms DOI Creative Commons
Raghad F. Al-Ansari, Khalid Zainulabdeen,

Maryam Hamed Jabir

et al.

Baghdad Journal of Biochemistry and Applied Biological Sciences, Journal Year: 2024, Volume and Issue: 5(4), P. 255 - 265

Published: Dec. 30, 2024

Amygdalin, also known as laetrile, has generated significant controversy within the scientific medical community regarding its efficacy a cancer treatment. Extracted primarily from seeds of fruits like apricots and almonds, it been promoted by certain groups potential cure for despite criticism toxicity minimal therapeutic value. This review aims to analyze available literature on amygdalin, focusing chemical characteristics, proposed mechanisms action, role in prevention therapy. A comprehensive preclinical data clinical trials was conducted assess amygdalin's effects associated risks. The analysis existing studies provides insights into complexity biological activity, including interactions suggested pathways treatment, while highlighting need further research clarify safety. Ultimately, contributes ongoing discussion surrounding position oncology emphasizes necessity continued exploration develop effective treatment strategies.

Language: Английский

Citations

0