DNA-methylation
clocks
inform
not
only
about
chronological
but
also
biological
age,
which
brings
a
high
resolution
and
precise
understanding
of
age-related
pathology
physiology.
Attempts
based
on
transcriptomic
epigenetic
approaches
arise
as
integrative
biomarkers
linking
the
quantification
stress
response
with
given
fitness
trait
may
help
to
identify
age
markers,
considered
welfare
indicators.
In
gilthead
sea
bream,
targeted
gene
expression
analyses
in
white
skeletal
muscle
proved
sirt1
reliable
marker
age-mediated
changes
energy
metabolism.
To
complete
list
auditing
biomarkers,
wide-analyses
one-
three-year
old
fish
were
combined.
After
discriminant
analysis,
668
differentially
expressed
transcripts
matched
those
containing
methylated
(DM)
regions
(14,366),
172
overlapping.
Through
enrichment
selection,
two
sets
genes
retained:
33
showing
an
opposite
trend
for
expression,
57
down-regulated
hypo-methylated.
The
first
set
displayed
apparently
more
reproducible
pattern
10
multifunctional
DM
CpG
regulatory
(sirt1,
smad1,
ramp1,
psmd2
–
up-regulated;
col5a1,
calcrl,
bmp1,
thrb,
spred2,
atp1a2
down-regulated)
deemed
candidate
markers
improved
bream.
Cells,
Journal Year:
2024,
Volume and Issue:
13(24), P. 2101 - 2101
Published: Dec. 18, 2024
The
aging
process
is
a
multifactorial
biological
phenomenon
starting
at
birth
and
persisting
throughout
life,
characterized
by
decline
in
physiological
functions
adaptability.
This
results
the
diminished
capacity
of
organisms
to
respond
environmental
changes
stressors,
leading
reduced
efficiency
metabolic,
immune,
hormonal
functions.
As
behavioral
flexibility
wanes,
older
individuals
face
longer
recovery
times
increased
vulnerability
diseases.
While
early
research
proposed
nine
core
hallmarks
mammalian
aging,
recent
studies
have
expanded
this
framework
twelve
key
characteristics:
epigenetic
changes,
genomic
instability,
telomere
shortening,
loss
proteostasis,
altered
metabolism,
mitochondrial
dysfunction,
cellular
senescence,
disrupted
intercellular
communication,
stem
cell
depletion,
immune
system
accumulation
toxic
metabolites,
dysbiosis.
Given
growing
interest
area,
we
propose
add
new
hallmark:
impaired
water
homeostasis.
potential
hallmark
could
play
critical
role
processes
might
open
directions
for
future
field.
review
enhances
our
understanding
aspects
dogs,
suggesting
clinical
intervention
strategies
prevent
control
issues
that
may
arise
from
pathological
degeneration
these
hallmarks.
Cells Tissues Organs,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: May 20, 2024
<b><i>Background:</i></b>
With
the
elderly
population
projected
to
double
by
2050,
there
is
an
urgent
need
address
increasing
prevalence
of
age-related
debilitating
diseases
and
ultimately
minimize
discrepancies
between
rising
lifespan
stagnant
health
span.
Cellular
reprogramming
overexpression
<i>Oct3</i>/<i>4</i>,
<i>Klf4</i>,
<i>Sox2</i>,
<i>cMyc</i>
(OKSM)
transcription
factors
gaining
attention
in
this
context
thanks
demonstrated
rejuvenating
effects
human
cell
cultures
live
mice,
many
which
can
be
uncoupled
from
dedifferentiation
loss
identity.
<b><i>Summary:</i></b>
Here,
we
review
current
evidence
impact
on
established
aging
hallmarks
underlying
mechanisms
that
mediate
these
effects.
We
also
provide
a
critical
assessment
challenges
translating
findings
and,
overall,
technologies
into
clinically
translatable
antiaging
interventions.
<b><i>Key
Messages:</i></b>
has
potential
reverse
at
least
partially
some
key
aging.
However,
further
research
necessary
determine
biological
significance
duration
such
changes
ensure
safety
as
rejuvenation
approach.
review,
hope
stimulate
new
directions
quest
extend
span
effectively.
DNA-methylation
clocks
inform
not
only
about
chronological
but
also
biological
age,
which
brings
a
high
resolution
and
precise
understanding
of
age-related
pathology
physiology.
Attempts
based
on
transcriptomic
epigenetic
approaches
arise
as
integrative
biomarkers
linking
the
quantification
stress
response
with
given
fitness
trait
may
help
to
identify
age
markers,
considered
welfare
indicators.
In
gilthead
sea
bream,
targeted
gene
expression
analyses
in
white
skeletal
muscle
proved
sirt1
reliable
marker
age-mediated
changes
energy
metabolism.
To
complete
list
auditing
biomarkers,
wide-analyses
one-
three-year
old
fish
were
combined.
After
discriminant
analysis,
668
differentially
expressed
transcripts
matched
those
containing
methylated
(DM)
regions
(14,366),
172
overlapping.
Through
enrichment
selection,
two
sets
genes
retained:
33
showing
an
opposite
trend
for
expression,
57
down-regulated
hypo-methylated.
The
first
set
displayed
apparently
more
reproducible
pattern
10
multifunctional
DM
CpG
regulatory
(sirt1,
smad1,
ramp1,
psmd2
–
up-regulated;
col5a1,
calcrl,
bmp1,
thrb,
spred2,
atp1a2
down-regulated)
deemed
candidate
markers
improved
bream.
