Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Dec. 26, 2024
Abstract
Background
Osteosarcoma
(OS),
the
most
prevalent
primary
malignant
bone
tumor
in
children
and
adolescents,
arises
from
bone-forming
mesenchymal
cells.
Despite
advancements
surgical
resection
neoadjuvant
chemotherapy
(cisplatin,
doxorubicin,
methotrexate),
resistance
remains
a
significant
challenge,
leading
to
poor
survival
rates
patients
with
metastatic
or
recurrent
OS.
Methods
In
this
study,
we
focused
on
role
of
OTULIN,
key
linear
deubiquitinating
enzyme,
OS
chemoresistance.
addition,
mechanistic
investigations
were
carried
out
identify
potential
downstream
targets
OTULIN
involved
cisplatin
resistance.
Results
Our
results
demonstrated
that
expression
was
significantly
upregulated
tissues
cell
lines
following
treatment
but
not
response
doxorubicin
methotrexate.
High
associated
reduced
sarcoma
patients.
Furthermore,
immunohistochemical
analysis
prechemotherapy
postchemotherapy
revealed
increased
samples.
vitro
plays
critical
mediating
Mechanistically,
GPX4
could
be
target
conferring
by
blocking
mitochondrial
apoptotic
pathway
ferroptosis.
Specifically,
prevents
proteasomal
degradation
reducing
its
ubiquitin
level,
thereby
Conclusion
This
study
highlights
importance
chemoresistance
provides
promising
approach
for
targeting
OTULIN-GPX4
axis
improve
prognosis
findings
offer
new
insights
into
molecular
mechanisms
underlying
suggest
therapeutic
future
clinical
interventions.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116023 - 116023
Published: Jan. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
11, P. 100400 - 100400
Published: Feb. 24, 2024
Cisplatin
is
a
platinum-based
chemotherapeutic
drug
utilized
in
the
treatment
of
many
solid-tissue
cancers;
it
associated
with
several
organ
toxicities.
For
ages,
Phoenix
Dactylifera,
known
as
"
large
jujube
or
dà
zǎo,"
Chinese
traditional
medicine,
has
been
employed
for
medicinal
applications.
The
present
study
assesses
role
Date
Fruit
Polysaccharides
(DFP)
cisplatin-induced
liver
injury
Rats
were
intraperitoneally
treated
single
therapeutic
dose
cisplatin
(5
mg/kg
body
weight)
and
then
orally
daily
without
50/100
weight
DFP
7
successive
days.
salvaging
effects
assessed
on
Cisplatin-induced
hepatic
damage,
by
investigating
function
markers,
oxidative
stress,
pro-inflammatory
biomarkers,
histopathological
assessment
morphology
hematoxylin/eosin
stain.
To
elucidate
contents,
functional
groups,
antioxidative
potentials
DFP,
chromatographic,
spectroscopic,
vitro
assays
analysed.
Exposure
to
led
considerable
escalation
tested
biomarkers
(ALP
ALT),
an
upsurge
levels/activities
malondialdehyde,
cytokines,
myeloperoxidase
significant
drop
level
GSH
(P
<
0.05)
compared
control.
Moreover,
there
also
obvious
decline
antioxidant
enzymes
(catalase,
SOD
GPx)
activities.
Contrarily,
post-treatment
significantly
inhibited
heightened
lipid
peroxidation,
inflammation,
stress
dose-dependently.
Analysis
chemical
constituents,
activities
demonstrated
important
monosaccharides
properties
DFP.
This
shows
ability
serve
probable
agent
damage
treatment.
Journal of Applied Oral Science,
Journal Year:
2025,
Volume and Issue:
33
Published: Jan. 1, 2025
Abstract
Inflammation,
oxidative
damage,
and
adenosine
triphosphate
(ATP)
depletion
play
a
role
in
the
pathogenesis
of
cisplatin
(CIS)-induced
oral
mucositis.
Objective:
The
purpose
this
research
is
to
examine
impact
ATP
against
potential
mucositis
development
cisplatin-treated
rats.
Methodology
All
rats
were
randomly
assigned
four
groups,
namely
healthy
control
group
(HG),
(ATPG),
Cisplatin
(CISG),
+
(ATCS).
Firstly,
4
mg/kg
was
administered
via
intraperitoneal
injection
(IP)
both
ATPG
ATCS
groups.
same
volume
normal
saline
injected
into
HG
CISG
After
1
h,
5
IP
drugs
taken
1x1
for
7
d.
Later,
tongue
tissues
collected
from
all
Biochemical,
macroscopic,
histopathological
examinations
performed
on
tissues.
Results:
inhibited
cisplatin-induced
damage
pro-inflammatory
cytokines
levels
tissue.
In
CIS
group,
significant
number
distinct
sulcus
formations
found
apex
corpus,
as
well
few
ulcer
foci
papilla
loss,
bleeding.
Meanwhile,
similar
appearance
tissue
observed.
Histopathologically,
it
determined
that
cisplatin-aggravated
filiform
papillae
decreased
when
administered,
arrangement
structures
epithelium,
blood
capillaries,
muscle
adipose
cell
groups
normal.
Conclusions:
Oral
caused
by
alleviated
ATP.
These
findings
may
be
useful
developing
new
therapeutic
approaches
prevent
or
treat
mucositis,
side
effect
so
severe
can
lead
treatment
discontinuation.
Sağlık Bilimleri Dergisi,
Journal Year:
2025,
Volume and Issue:
34(1), P. 1 - 7
Published: April 7, 2025
Cisplatin
is
an
anticancer
agent
that
frequently
used
in
the
treatment
of
solid
tumors.
However,
widespread
organ
toxicity
most
important
factor
limiting
its
use.
Lung
has
also
become
increasing
concern
recent
years.
This
study
aimed
to
evaluate
protective
roles
myricetin,
a
natural
antioxidant
found
plants,
cisplatin-induced
lung
injury.
For
this
purpose,
twenty-eight
male
Wistar
rats
were
randomly
assigned
four
equal
groups
(n=7):
control,
cisplatin,
and
myricetin+cisplatin.
The
control
group
received
physiological
saline;
myricetin
was
given
(10
mg/kg)
intraperitoneally
for
seven
consecutive
days.
cisplatin
single
dose
(7.5
on
seventh
day.
myricetin+cisplatin
treated
with
days,
at
end
day,
administered.
One
day
later,
sacrificed,
their
lungs
removed.
sections
obtained
from
stained
hematoxylin
&
eosin,
histopathological
damage
evaluated.
Biochemical
analyses
performed
using
total
oxidant
status,
hypoxia-inducible
factor-1α.
In
results,
significant
inflammatory
cell
infiltration,
cellular
deterioration,
loss
tissue
integrity
observed
group.
contrast,
group,
structure
alveolar
order
largely
preserved,
infiltration
minimal.
Pretreatment
reduced
status
factor-1α
while
levels.
Taken
together,
indicates
pretreatment
could
serve
therapeutic
purposes
