Exploring the microbiome-gut-testis axis in testicular germ cell tumors
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 9, 2025
The
microbiome-gut-testis
axis
has
emerged
as
a
significant
area
of
interest
in
understanding
testicular
cancer,
particularly
germ
cell
tumors
(TGCTs),
which
represent
the
most
common
malignancy
young
men.
interplay
between
gut
and
microbiomes
is
hypothesized
to
influence
tumorigenesis
reproductive
health,
underscoring
complex
role
microbial
ecosystems
disease
pathology.
encompasses
interactions
microbiome,
systemic
immune
modulation,
local
microenvironment
testis.
Dysbiosis
or
may
contribute
altered
responses,
inflammation,
hormonal
imbalances,
potentially
playing
pathogenesis
TGCTs.
Concurrently,
seminal
have
been
linked
variations
sperm
quality,
fertility
potential,
possibly
cancer
susceptibility,
need
for
further
evaluation.
This
review
explores
emerging
context
highlighting
its
implications
onset,
progression,
treatment
efficacy,
toxicity.
Identifying
potential
biomarkers,
followed
by
microbiota
modulation
restore
balanced
community,
might
offer
novel
supportive
strategy
improving
efficacy
refractory
TGCT
patients
while
reducing
chemotherapy-induced
We
suggest
better
association
dysregulated
environments
TGCTs
emphasizes
pathways
microbiome
cancer.
Language: Английский
The Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers?
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(2), P. 315 - 315
Published: Feb. 1, 2025
The
human
microbiome,
which
encompasses
microbial
communities
and
their
genetic
material,
significantly
influences
health
disease,
including
cancer.
urogenital
microbiota,
naturally
present
in
the
urinary
genital
tracts,
interact
with
factors
such
as
age,
lifestyle,
conditions
to
affect
homeostasis
carcinogenesis.
Studies
suggest
that
alterations
this
microbiota
contribute
development
progression
of
genitourinary
cancers,
emphasizing
concept
oncobiome,
refers
contributions
Similarly,
gut
can
influence
hormone
levels
systemic
inflammation,
impacting
cancers
cervical
prostate
Advanced
studies
indicate
have
distinct
profiles
may
serve
diagnostic
biomarkers
or
therapeutic
targets.
Dysbiosis
correlates
bladder
kidney
Additionally,
effectiveness
cancer
treatments.
However,
further
research
is
necessary
clarify
causality,
role
metabolites,
hormonal
regulation.
aim
review
understand
these
dynamics
opportunities
for
innovative
diagnostics
therapies,
highlighting
need
integration
microbiology,
oncology,
genomics
explore
cancers.
For
this,
a
comprehensive
search
relevant
databases
was
conducted,
applying
specific
inclusion
exclusion
criteria
identify
examining
association
between
Research
into
mechanisms
by
pave
way
new
approaches,
ultimately
improving
patient
outcomes.
Language: Английский
Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission
S Habibi,
No information about this author
Shabbou Bahramian,
No information about this author
Saeedeh Zare Jalise
No information about this author
et al.
Critical Reviews in Oncology/Hematology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104715 - 104715
Published: April 1, 2025
Language: Английский
Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer
Adviti Naik,
No information about this author
Boucif Lattab,
No information about this author
Hanan Qasem
No information about this author
et al.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
32(1), P. 200768 - 200768
Published: Jan. 26, 2024
Cancer
care
has
witnessed
remarkable
progress
in
recent
decades,
with
a
wide
array
of
targeted
therapies
and
immune-based
interventions
being
added
to
the
traditional
treatment
options
such
as
surgery,
chemotherapy,
radiotherapy.
However,
despite
these
advancements,
challenge
achieving
high
tumor
specificity
while
minimizing
adverse
side
effects
continues
dictate
benefit-risk
balance
cancer
therapy,
guiding
clinical
decision
making.
As
such,
targeting
testis
antigens
(CTAs)
offers
exciting
new
opportunities
for
therapeutic
intervention
since
they
display
highly
specific
expression
patterns,
natural
immunogenicity
play
pivotal
roles
various
biological
processes
that
are
critical
cellular
fitness.
In
this
review,
we
delve
deeper
into
how
CTAs
contribute
regulation
maintenance
genomic
integrity
cancer,
mechanisms
can
be
exploited
specifically
target
eradicate
cells.
We
review
current
trials
aforementioned
CTAs,
highlight
promising
pre-clinical
data
discuss
challenges
future
perspectives
development
CTA-based
strategies
exploit
instability.
Language: Английский