Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer DOI Creative Commons
Adviti Naik, Boucif Lattab,

Hanan Qasem

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 32(1), P. 200768 - 200768

Published: Jan. 26, 2024

Cancer care has witnessed remarkable progress in recent decades, with a wide array of targeted therapies and immune-based interventions being added to the traditional treatment options such as surgery, chemotherapy, radiotherapy. However, despite these advancements, challenge achieving high tumor specificity while minimizing adverse side effects continues dictate benefit-risk balance cancer therapy, guiding clinical decision making. As such, targeting testis antigens (CTAs) offers exciting new opportunities for therapeutic intervention since they display highly specific expression patterns, natural immunogenicity play pivotal roles various biological processes that are critical cellular fitness. In this review, we delve deeper into how CTAs contribute regulation maintenance genomic integrity cancer, mechanisms can be exploited specifically target eradicate cells. We review current trials aforementioned CTAs, highlight promising pre-clinical data discuss challenges future perspectives development CTA-based strategies exploit instability.

Language: Английский

Exploring the microbiome-gut-testis axis in testicular germ cell tumors DOI Creative Commons
Sona Ciernikova, Aneta Sevcikova, Michal Mego

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 9, 2025

The microbiome-gut-testis axis has emerged as a significant area of interest in understanding testicular cancer, particularly germ cell tumors (TGCTs), which represent the most common malignancy young men. interplay between gut and microbiomes is hypothesized to influence tumorigenesis reproductive health, underscoring complex role microbial ecosystems disease pathology. encompasses interactions microbiome, systemic immune modulation, local microenvironment testis. Dysbiosis or may contribute altered responses, inflammation, hormonal imbalances, potentially playing pathogenesis TGCTs. Concurrently, seminal have been linked variations sperm quality, fertility potential, possibly cancer susceptibility, need for further evaluation. This review explores emerging context highlighting its implications onset, progression, treatment efficacy, toxicity. Identifying potential biomarkers, followed by microbiota modulation restore balanced community, might offer novel supportive strategy improving efficacy refractory TGCT patients while reducing chemotherapy-induced We suggest better association dysregulated environments TGCTs emphasizes pathways microbiome cancer.

Language: Английский

Citations

1
The Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers? DOI Creative Commons
Gülfem Ece, Ahmet Aktaş, Ayşe Caner

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 315 - 315

Published: Feb. 1, 2025

The human microbiome, which encompasses microbial communities and their genetic material, significantly influences health disease, including cancer. urogenital microbiota, naturally present in the urinary genital tracts, interact with factors such as age, lifestyle, conditions to affect homeostasis carcinogenesis. Studies suggest that alterations this microbiota contribute development progression of genitourinary cancers, emphasizing concept oncobiome, refers contributions Similarly, gut can influence hormone levels systemic inflammation, impacting cancers cervical prostate Advanced studies indicate have distinct profiles may serve diagnostic biomarkers or therapeutic targets. Dysbiosis correlates bladder kidney Additionally, effectiveness cancer treatments. However, further research is necessary clarify causality, role metabolites, hormonal regulation. aim review understand these dynamics opportunities for innovative diagnostics therapies, highlighting need integration microbiology, oncology, genomics explore cancers. For this, a comprehensive search relevant databases was conducted, applying specific inclusion exclusion criteria identify examining association between Research into mechanisms by pave way new approaches, ultimately improving patient outcomes.

Language: Английский

Citations

0
Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission DOI

S Habibi,

Shabbou Bahramian,

Saeedeh Zare Jalise

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104715 - 104715

Published: April 1, 2025

Language: Английский

Citations

0
Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer DOI Creative Commons
Adviti Naik, Boucif Lattab,

Hanan Qasem

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 32(1), P. 200768 - 200768

Published: Jan. 26, 2024

Cancer care has witnessed remarkable progress in recent decades, with a wide array of targeted therapies and immune-based interventions being added to the traditional treatment options such as surgery, chemotherapy, radiotherapy. However, despite these advancements, challenge achieving high tumor specificity while minimizing adverse side effects continues dictate benefit-risk balance cancer therapy, guiding clinical decision making. As such, targeting testis antigens (CTAs) offers exciting new opportunities for therapeutic intervention since they display highly specific expression patterns, natural immunogenicity play pivotal roles various biological processes that are critical cellular fitness. In this review, we delve deeper into how CTAs contribute regulation maintenance genomic integrity cancer, mechanisms can be exploited specifically target eradicate cells. We review current trials aforementioned CTAs, highlight promising pre-clinical data discuss challenges future perspectives development CTA-based strategies exploit instability.

Language: Английский

Citations

3