Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111617 - 111617
Published: Sept. 13, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1158 - 1158
Published: Sept. 25, 2024
Hydrogen sulfide (H
Language: Английский
Citations
10
Balneo and PRM Research Journal, Journal Year: 2024, Volume and Issue: 15(Vol.15, no. 2), P. 702 - 702
Published: June 21, 2024
Balneotherapy, treating diseases by bathing in mineral-rich waters and mud, has a long historical application across various cultures. Despite its widespread use, comprehensive studies on biological impacts are scant, particularly quantifying effects at the cellular systemic levels. This study aims to rigorously investigate of therapeutic mud mineral waters, providing scientific basis for their clinical application. We focused elucidating mechanisms behind observed determining these natural resources' safety profiles. Employing dual approach, we conducted both vitro vivo studies. For experiments, human fibroblast cells were treated with different concentrations extracts assess cytotoxicity, proliferation, apoptosis pathways. assessments, Wistar rats exposed water treatments, subsequent evaluations biochemical markers blood urine indicative physiological changes. Our findings reveal that exert dose-dependent influence cell viability, low promoting proliferation while higher induce apoptosis. In treatments demonstrated significant modulation inflammatory oxidative stress parameters without evident toxicity. The demonstrate pronounced effects, enhancing health modulating responses adverse side effects. Keywords: Mud, Mineral Waters, Inflammatory Markers, Oxidative Stress
Language: Английский
Citations
5
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062
Published: Aug. 30, 2024
Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.
Language: Английский
Citations
5
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 344 - 344
Published: Feb. 27, 2025
Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2067 - 2079
Published: March 1, 2025
Neurodegenerative diseases are often linked to oxidative stress (OS), which worsen neuroinflammation and cause neuronal damage. Managing OS with gasotransmitters such as hydrogen sulphide (H2S) is a promising therapeutic approach protecting brain cells from AP39, mitochondria-targeted H2S donor, has shown neuroprotective potential by reducing improving mitochondrial function. However, its clinical application limited due poor stability rapid release, necessitating drug delivery system enhance efficacy. This study aimed develop novel AP39-loaded liposomal formulation provide controlled facilitate AP39 permeation across the blood-brain barrier (BBB), assess functional effects in mitigating preserving unilamellar liposomes were prepared via ethanol injection characterised for size, polydispersity, zeta potential. Entrapment efficiency was determined using HPLC, while cytotoxicity assessed human vein endothelial (HUVEC) neuroblastoma (SHSY5Y) cells. Liposomal permeability, release kinetics, cellular uptake evaluated microvasculature BBB model. Mitochondrial function under Seahorse XFe24 Analyzer. had an average size of 135.92 ± 10.05 nm, 17.35 3.40 mV, entrapment 84.48% 4.7. Cytotoxicity studies showed no adverse after 4 h. Cellular encapsulated significantly higher (7.13 0.28 µg) than free form (5.8 0.31 µg). The model demonstrated sustained (7.28 µg/mL vs 6.44 AP39). assays confirmed preserved antioxidant properties enhanced oxygen consumption. Our encapsulating improves stability, promotes enhances permeability effects. These findings indicate that suitable further investigate treatment neurodegenerative diseases.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 360 - 360
Published: March 19, 2025
Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and driver of neuronal damage. Hydrogen sulfide (H2S), versatile gasotransmitter, exhibits similarly “Janus-faced” nature, potent antioxidant cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles oxidative H2S normal cellular physiology focusing on disease progression. We highlight potential therapeutic opportunities for targeting redox sulfur-based systems diseases by elucidating intricate balance between these opposing forces.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3131 - 3131
Published: March 28, 2025
Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function neurotransmitter release neuronal circuits. By synthesizing findings from animal cellular models, we investigate impacts of enzymatic production exogenous on excitatory currents, long-term potentiation, intracellular calcium signaling. Data suggest that interacts directly with subunits, altering excitability. Simultaneously, promotes neurotransmitters such glutamate GABA, shaping dynamics plasticity. Furthermore, reports indicate disruptions metabolism contribute to cognitive impairments neurodegenerative disorders, underscoring potential therapeutic value targeting H2S-mediated Although precise mechanisms H2S-induced changes strength remain elusive, growing body positions significant regulator formation processes. calls for more rigorous exploration into underpinnings paving way novel pharmacological interventions dysfunction.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11272 - 11272
Published: Oct. 19, 2024
Recent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through microbiota–gut–brain axis, including Alzheimer’s disease (AD). This review aims to provide a comprehensive synthesis recent findings on involvement neuroinflammatory processes associated with AD, emphasizing novel insights therapeutic implications. reveals that dysbiosis AD patients’ is linked heightened peripheral central inflammatory responses. Specific bacterial taxa, such as Bacteroides Firmicutes gut, well Porphyromonas gingivalis cavity, are notably altered leading significant changes microglial activation cytokine production. Gut alterations increased intestinal permeability, facilitating translocation endotoxins like lipopolysaccharides (LPS) into bloodstream exacerbating by activating brain’s toll-like receptor 4 (TLR4) pathways. Furthermore, microbiota-derived metabolites, short-chain fatty acids (SCFAs) amyloid peptides, can cross blood-brain barrier modulate While microbial amyloids may contribute amyloid-beta aggregation brain, certain SCFAs butyrate exhibit anti-inflammatory properties, suggesting potential avenue mitigate neuroinflammation. not only highlights critical pathology but also offers ray hope modulating could represent strategy for reducing slowing progression.
Language: Английский
Citations
3
Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2670 - 2670
Published: Nov. 23, 2024
Microbiota-derived hydrogen sulfide (H2S) plays a crucial role in modulating the gut–brain axis, with significant implications for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. H2S is produced by sulfate-reducing bacteria gut acts critical signaling molecule influencing brain health via various pathways, including regulating inflammation, oxidative stress, immune responses. maintains barrier integrity at physiological levels prevents systemic which could impact neuroinflammation. However, has dual or Janus face, excessive production, often resulting from dysbiosis, can compromise intestinal exacerbate processes promoting neuroinflammation glial cell dysfunction. This imbalance linked to early pathogenesis of Parkinson’s diseases, where overproduction exacerbates beta-amyloid deposition, tau hyperphosphorylation, alpha-synuclein aggregation, driving neuroinflammatory responses neuronal damage. Targeting microbiota restore homeostasis through dietary interventions, probiotics, prebiotics, fecal transplantation presents promising therapeutic approach. By rebalancing microbiota-derived H2S, these strategies may mitigate neurodegeneration offer novel treatments underscoring axis maintaining central nervous system health.
Language: Английский
Citations
3