Changes in rat plasma proteomes during the first week after birth
Frontiers in Veterinary Science,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 25, 2025
Blood
plasma
is
the
most
informative
body
fluid,
containing
large
amounts
of
substances
that
are
released
by
active
secretion
or
leakage
from
tissues
and
cells.
Therefore,
changes
reflect
state.
To
explore
in
during
early
life
Wistar-rats,
proteomes
newborn
first-week
rats
were
investigated
using
liquid
chromatography-tandem
mass
spectrometry.
A
total
639
proteins
identified
at
both
developmental
stages
570
used
for
quantitative
analysis.
The
rats,
compared
to
label-free
quantification,
showed
levels
42
significantly
increased
while
those
17
decreased.
Plasma
proteomic
patterns
can
be
easily
separated
differential
protein
cluster
Using
Ingenuity
Pathway
analysis
tool,
some
pathways
including
LXR/RXR
Activation,
DHCR24
Signaling
Pathway,
Acute
Phase
Response
Signaling,
Detoxification
Reactive
Oxygen
Species
enhanced.
Over
10
categories
related
development
functions
enriched.
distinct
rats.
These
would
make
it
easier
survive.
This
first
study
spectrometry
investigate
rat
proteome
changes,
providing
a
basis
clues
studying
animal
development.
Language: Английский
Apolipoproteins in ischemic stroke progression and recovery: Key molecular mechanisms and therapeutic potential
Tamara Etuzé,
No information about this author
Hortense Triniac,
No information about this author
Ze Zheng
No information about this author
et al.
Neurobiology of Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106896 - 106896
Published: April 1, 2025
Ischemic
stroke,
responsible
for
80
%
of
all
strokes,
is
a
leading
cause
mortality
globally.
While
altered
lipids
profiles
are
recognized
as
modifiable
risk
factors,
their
direct
impact
on
stroke
outcomes
less
understood
due
to
the
brain's
distinct
lipid
metabolism
and
selective
permeability
blood-brain
barrier
lipoproteins.
As
key
components
lipoproteins,
apolipoproteins
essential
transport,
redistribution
in
both
central
nervous
system
peripheral
blood
circulation.
This
review
provides
an
updated
perspective
influence
brain-expressed
(such
ApoE,
ApoA-I,
ApoJ,
ApoD,
others)
those
that
cross
damaged
following
ischemic
stroke.
We
explore
hypotheses
regarding
involvement
molecular
pathways
related
metabolism,
inflammation,
oxidative
stress,
mitochondrial
function
integrity.
Through
this
synthesis,
we
aim
identify
potential
biomarkers
therapeutic
targets,
thereby
enhancing
our
understanding
progression
contributing
improved
clinical
outcomes.
Language: Английский
Apolipoproteins and Lipoproteins in Health and Disease 2.0
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6183 - 6183
Published: June 4, 2024
Cardiovascular
diseases
(CVDs)
remain
the
leading
cause
of
mortality
worldwide,
accounting
for
32%
global
deaths,
according
to
World
Health
Organization
(WHO)
[...]
Language: Английский
Bidirectional Mendelian randomization analysis of plasma lipidome and psychiatric disorders
Ling Yu,
No information about this author
Qing Long,
No information about this author
Yunqiao Zhang
No information about this author
et al.
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
Language: Английский
Role and Diagnostic Significance of Apolipoprotein D in Selected Neurodegenerative Disorders
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(24), P. 2814 - 2814
Published: Dec. 14, 2024
The
World
Health
Organization
in
2021
ranked
Alzheimer’s
disease
and
other
dementias
as
the
seventh
leading
cause
of
death
globally.
Neurodegenerative
disorders
are
progressive,
intractable,
often
fatal
diseases.
Early
diagnosis
may
allow
patients
to
enjoy
prolonged
survival
with
attenuated
symptomatology
because
early
intervention.
Hence,
further
research
on
finding
non-invasive
biomarkers
neurodegenerative
diseases
is
warranted.
Apolipoprotein
D
(ApoD)
a
glycoprotein
involved
lipid
metabolism,
oxidative
stress
regulation,
inflammation.
It
expressed
various
body
fluids
regions
central
nervous
system.
ApoD’s
roles
neuroprotection,
transport,
anti-inflammatory
processes
crucial
far
prevention
pathologies
concerned.
This
review
aims
summarize
background
knowledge
ApoD,
it
covers
studies
indexed
PubMed,
Scopus,
Web
Science
databases.
discusses
evidence
for
multifaceted
ApoD
mechanisms
pathogenesis
multiple
sclerosis,
disease,
Parkinson’s
disease.
be
specific,
sensitive,
easily
obtained,
cost-effective
biomarker
its
applications
diagnostic
practices,
treatment
strategies,
advancing
disorders’
management.
Language: Английский