Tumor-associated senescent macrophages, their markers and their role in the tumor microenvironment (review) DOI
Tamara V. Pukhalskaia,

T. R. Yrakova,

Daria A. Bogdanova

et al.

Биохимия, Journal Year: 2024, Volume and Issue: 89(5), P. 818 - 832

Published: Nov. 14, 2024

Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and most abundant population immune cells infiltrating a tumor. TAMs can largely determine direction anti-tumor response. promote it or, conversely, contribute to formation immunosuppressive TME that allows tumors evade control. Through interactions with or other in microenvironment, as result action anti-cancer therapy, enter senescence. In this review, we have attempted summarize information available literature on role senescent tumors. With recent development senolytic therapeutic strategies aimed at removing from organism. It seems discuss functions potential drugs reprogramming enhance response improve efficacy cancer treatment.

Language: Английский

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy DOI Open Access

Maya V. Voronina,

Anastasia S. Frolova, Ekaterina Kolesova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4087 - 4087

Published: April 6, 2024

Cellular survival hinges on a delicate balance between accumulating damages and repair mechanisms. In this intricate equilibrium, oxidants, currently considered physiological molecules, can compromise vital cellular components, ultimately triggering cell death. On the other hand, cells possess countermeasures, such as autophagy, which degrades recycles damaged molecules organelles, restoring homeostasis. Lysosomes their enzymatic arsenal, including cathepsins, play critical roles in balance, influencing cell’s fate toward either apoptosis mechanisms of regulated death or autophagy. However, interplay reactive oxygen species (ROS) cathepsins these life-or-death pathways transcends simple cause-and-effect relationship. These elements directly indirectly influence each other’s activities, creating complex web interactions. This review delves into inner workings highlighting pivotal role ROS interplay.

Language: Английский

Citations

13
Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory parameters DOI Creative Commons
Nina Kemala Sari,

Stepvia Stepvia,

Muhana Fawwazy Ilyas

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Introduction The aging process is frequently associated with a decline in functional capacity, endurance, muscle quality, and overall quality of life. Examining aging-related biomarkers often requires significant time financial resources, underscoring the need for straightforward practical indicator. This study aims to investigate association between handgrip strength laboratory parameters elderly population Indonesia. Methods A cross-sectional was conducted involving 109 participants aged 60–82 years. Handgrip measured using Jamar hydraulic hand dynamometer PLUS+ digital dynamometer. Aging-related were defined as those indicating physiological processes. Results revealed several parameters, including leukocyte count, absolute neutrophil lymphocyte neutrophil/lymphocyte ratio, erythrocyte sedimentation rate. Discussion These findings suggest that could serve cost-effective, non-invasive predictor health status older adults. Its utility highlights its potential guiding interventions targeting population.

Language: Английский

Citations

1
Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment DOI
Tamara V. Pukhalskaia,

Taisiya R. Yurakova,

Daria A. Bogdanova

et al.

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(5), P. 839 - 852

Published: May 1, 2024

Language: Английский

Citations

4
The diversity of natural killer cell functional and phenotypic states in cancer DOI

Kumar Rishabh,

Sandro Matosevic

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Advancing Single-Cell Detection of Senescent Cells: Laboratory Methods and Clinical Applications DOI Open Access

Stefan Hardy Lung,

Thomas Lung

OBM Geriatrics, Journal Year: 2025, Volume and Issue: 09(02), P. 1 - 32

Published: April 14, 2025

Cellular senescence (aging) is a physiological process that plays role in tissue remodeling, wound healing, and embryogenesis. Prolonged of cells can have detrimental effects trigger secretory phenotype (SASP, senescence-associated phenotype), degenerative disorders, cancer, age-related diseases. Suitable biomarkers range different laboratory methods are used to investigate these complex relationships vitro vivo. Since universal biomarker for cell has not yet been identified, numerous identify senescent cell. The detection quantification their SASP provide the basis targeted treatment patient. In parallel, single-cell analysis also required quantitative assessment therapy result. Depending on facilities performing analysis, wide available. this review, we general overview accessible techniques such as immunohistochemistry using microscopy automated flow cytometry introduce new possibilities by modern like mass spectrometry or genetic method single cells. focus here use routine laboratories. classical with enzyme immunoassays, measurement products (IL-6, IL-8), part work. This review discusses ideas visualisation clinical patient data gerontology. An outlook potential future optimization improve rejuvenate status patients cellular organ-specific level discussed.

Language: Английский

Citations

0
sc-MULTI-omics approach in nano-rare diseases: understanding the pathophysiological mechanism of Mulvihill-Smith Syndrome DOI Creative Commons

Angelika Rieß,

Cristiana Roggia,

Antje Schulze Selting

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 9, 2025

Language: Английский

Citations

0
Decoding T cell senescence in cancer: is revisiting required? DOI

Sophia Magkouta,

Efrosyni Markaki,

Konstantinos Evangelou

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Cellular Senescence and Anti-Aging Strategies in Aesthetic Medicine: A Bibliometric Analysis and Brief Review DOI Creative Commons

Huilan Zheng,

Jingping Wu,

Jinhong Feng

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2243 - 2259

Published: Oct. 1, 2024

Background: Skin aging is the most obvious feature of human aging, and delaying has become a hot difficult research topic in aesthetic medicine. The accumulation dysfunctional senescent cells one important mechanisms skin based on which series anti-aging strategies have been generated. In this paper, from perspective cellular senescence, we utilize bibliometrics review to explore hotspots trends field, with view providing references for health Methods: We obtained literature related field Web Science Core Collection database 1994 2024. Bibliometrix packages R, CiteSpace, VOSviewer, Origin, Scimago Graphica were utilized data mining visualization. Results: A total 2,796 documents included analysis. overall trend publications showed continuous rapid increase 2016– 2023, but citations improved poorly over time. Journal Cosmetic Dermatology, Investigative Experimental Gerontology are core journals. Kim J, Lee JH, S, Rattan SIS, Chung JH authors field. Seoul National University first terms publications. Korea country publications, USA citations. Top 10 keywords include: gene-expression, skin, cell, oxidative stress, antioxidants, vitro, fibroblasts, mechanism, cancer. Current focused neurodegeneration, rejuvenation, molecular docking, fibrosis, wound healing, SASP, barrier, antioxidants. reflect topics such as major pathways process, relationship tumors. Conclusion: This rapidly rising recent years. Relevant focus senescence-associated secretory phenotype. Anti-aging targeting senescence hold great promise, including removal or attenuation SASP factors, corresponding senolytics senomorphics therapies, respectively. Keywords: medicine, senolytic,

Language: Английский

Citations

1
PD-1+ T lymphocyte proportions and hospitalized exacerbation of COPD: a prospective cohort study DOI Creative Commons
Hong Xue, Xiuyan Lan, Ting Xue

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: May 24, 2024

To evaluate the predictive value of PD-1 expression in T lymphocytes for rehospitalization due to acute exacerbations COPD (AECOPD) discharged patients. 115 participants hospitalized with (average age 71.8 ± 6.0 years) were recruited at Fujian Provincial Hospital. PD1+T proportions (PD1+T%), baseline demographics and clinical data recorded hospital discharge. AECOPD re-admission collected 1-year follow-up. Kaplan-Meier analysis compared time readmissions among groups stratified by PD1+T%. Multivariable Cox proportional hazards regression determined correlation between PD1+T%, potential confounders, re-admission. ROC DCA evaluated PD1+T% enhancing values models, BODE CODEX. 68 (59.1%) readmitted, those readmission exhibited significantly elevated PD-1+CD4+T/CD4+T% PD-1+CD8 + T/CD8 T% non-readmitted counterparts. PD1+ lymphocyte levels statistically correlated CODEX indices. demonstrated that Higher had reduced (logRank p < 0.05). identified high PD1+CD4+T PD1+CD8+T ratios as risk factors readmission, hazard 1.384(95%CI [1.043-1.725]) 1.401(95%CI [1.013-1.789]), respectively. Notably, patients aged 70 years fewer than twice episodes previous year, counts increased readmission(p The model, incorporating superior discrimination index index, AUC 0.763(95%CI [0.633-0.893]) 0.734(95%CI [0.570-0.899]) (DeLong's test 0.05).The illustrates integrating into models enhances utility aiding decision-making. Evaluation offer a novel perspective identifying high-risk patients, potentially providing insights management. Chinese Clinical Trial Registry (ChiCTR, URL: www.chictr.org.cn/ ), Registration number: ChiCTR2200055611 Date Registration: 2022-01-14.

Language: Английский

Citations

0
Consideration of T-Cell Profile in the Examination of Statin Efficacy in Inflammatory Diseases, Neurodegeneration, and Neurocognitive Performance DOI Creative Commons
Matthew A Hintermayer,

Daniel Mendelson,

Jae Hyun Byun

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(8)

Published: July 4, 2024

Statins are a cornerstone in the medical management of cardiovascular disease, yet their efficacy varies greatly between individuals. In this commentary, we outline evidence for role CD4+CD28null T-cell expansion as critical moderator effects statins preventing events via reduction pathological inflammation. Given relationship, argue that profiles should be considered patient characteristic clinical and preclinical studies examining statin other age- inflammation-related pathologies. We discuss implications may have use numerous disease processes-notably, dementia neurocognitive dysfunction-and potential to used prognosticator rheumatoid arthritis, Alzheimer's multiple sclerosis.

Language: Английский

Citations

0