The autonomous nervous system and the cholinergic anti-inflammatory reflex in postoperative neurocognitive disorders

Current Opinion in Anaesthesiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Purpose of review Postoperative delirium (POD) is a common and serious complication after surgery. It associated with postoperative neurocognitive disorder (PNCD). The vagal cholinergic anti-inflammatory pathway (CAP) has been hypothesized to play role in POD/PNCD may be target for interventions such as transcutaneous auricular stimulation (taVNS). We aim associations heart rate variability (HRV) an indicator function POD immune reaction well taVNS potential preventive intervention POD. Recent findings Autonomous nervous system (ANS) dysfunction was finding studies analysing HRV cognitive dysfunction, but results were heterogeneous. There no evidence from analysis that activity prevents overshooting activation, help identify patients at risk infections. Animal preliminary trials suggest used prevent POD/PNCD. Summary Our provides CAP suppression Future should consider high tone also mediate immunosuppression surgical patients, yielding increased Although promising approach POD/POCD, future take these concerns into account.

Language: Английский

Gelatin methacryloyl hydrogel encapsulating molybdenum-inspired macrophage-derived exosomes accelerates wound healing via immune regulation and angiogenesis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 291, P. 138947 - 138947

Published: Dec. 24, 2024

Language: Английский