Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1395 - 1395
Published: April 21, 2025
Conjugated
linoleic
acid
(CLA)
is
a
bioactive
compound
known
for
its
anti-inflammatory,
anti-carcinogenic,
and
metabolic
effects,
with
growing
interest
in
role
supporting
bone
health.
Preclinical
studies,
particularly
those
involving
the
t10c12
isomer,
have
shown
that
CLA
can
enhance
mineral
density
(BMD)
by
enhancing
formation
reducing
resorption,
indicating
potential
as
therapeutic
agent
to
improve
However,
clinical
trials
yielded
inconsistent
results,
underscoring
difficulty
translating
animal
model
successes
human
applications.
A
major
challenge
CLA’s
low
water
solubility,
poor
absorption,
limited
bioavailability,
which
restrict
effectiveness.
To
address
these
issues,
nanoparticle-based
delivery
systems
been
proposed
stability,
resistance
oxidative
damage,
thereby
bioactivity.
Recent
studies
also
suggest
electrical
stimulation
stimulate
regeneration
promoting
cell
proliferation,
differentiation,
adherence
scaffolds.
This
review
explores
combined
use
of
supplementation
novel
approach
improving
health,
osteoporosis
management.
By
integrating
biological
effects
regenerative
stimulation,
this
multimodal
strategy
offers
promising
method
restoration,
significant
implications
applications
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1431 - 1431
Published: Jan. 24, 2024
Sunlight,
despite
its
benefits,
can
pose
a
threat
to
the
skin,
which
is
natural
protective
barrier.
Phototoxicity
caused
by
overexposure,
especially
ultraviolet
radiation
(UVR),
results
in
burns,
accelerates
photoaging,
and
causes
skin
cancer
formation.
Natural
substances
of
plant
origin,
i.e.,
polyphenols,
flavonoids,
photosynthetic
pigments,
protect
against
effects
radiation,
acting
not
only
as
photoprotectors
like
filters
but
antioxidant
anti-inflammatory
remedies,
alleviating
photodamage
skin.
Plant-based
formulations
are
gaining
popularity
an
attractive
alternative
synthetic
filters.
Over
past
20
years,
large
number
studies
have
been
published
assess
photoprotective
products,
primarily
through
their
antioxidant,
antimutagenic,
anti-immunosuppressive
activities.
This
review
selects
most
important
data
on
efficacy
selected
carotenoid
representatives
from
vivo
animal
models
humans,
well
vitro
experiments
performed
fibroblast
keratinocyte
cell
lines.
Recent
research
carotenoids
associated
with
lipid
nanoparticles,
nanoemulsions,
liposomes,
micelles
reviewed.
The
focus
was
collecting
those
nanomaterials
that
serve
improve
bioavailability
stability
antioxidants
activity.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 27
Published: Jan. 9, 2025
Molecular
Dynamics
(MD)
simulations
are
now
widely
utilized
in
pharmaceutical
nanotechnology
to
gain
deeper
understanding
of
nanoscale
processes
imperative
drug
design.
This
review
has
also
detailed
how
MD
simulation
can
be
employed
the
study
drug-nanocarrier
interactions,
controlling
release
chemical
compounds
from
delivery
systems
and
increasing
solubility
bioavailability
nanocarriers.
Furthermore,
contributes
examining
systems,
measuring
toxic
effects,
determining
biocompatibility
nanomedical
systems.
With
incorporation
artificial
intelligence
use
hybrid
gone
a
step
ahead
model
other
niches
biology
that
make
tremendous
opening
develop
highly
selective
nanomedications.
Nevertheless,
with
well-known
issues
such
as
computational
constraints
discrepancy
between
silico
experiment
results,
remains
work
progress,
considerable
promise
for
replacing
or
supplementing
existing
approaches
development
precision
medicine
nanomedicine,
continued
progression
healthcare
hopeful.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 140 - 140
Published: Jan. 21, 2025
Background/Objectives:
The
present
study
focused
on
the
formulation
and
evaluation
of
novel
topical
systems
containing
Salvia
officinalis
(sage),
emphasizing
their
antioxidant
anti-inflammatory
properties.
Sage,
rich
in
carnosol,
offers
considerable
therapeutic
potential,
yet
its
low
water
solubility
limits
effectiveness
traditional
formulations.
aim
our
experimental
work
was
to
improve
thus
bioavailability
active
ingredient
by
developing
self-nano/microemulsifying
drug
delivery
(SN/MEDDSs)
with
help
Labrasol
Labrafil
M
as
nonionic
surfactants,
Transcutol
HP
co-surfactant,
isopropyl
myristate
oily
phase.
Methods:
formulations
were
characterized
for
droplet
size,
zeta
polydispersity
index
(PDI),
encapsulation
efficacy,
stability.
composition
exhibiting
most
favorable
characteristics,
particle
sizes
falling
within
nanoscale
range,
incorporated
into
a
cream
gel,
which
compared
textural
properties,
carnosol
penetration,
biocompatibility
efficacy.
Results:
Release
studies
conducted
using
Franz
diffusion
cells
demonstrated
that
SNEDDS-based
achieved
up
80%
release,
outperforming
gels.
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
test
enzyme-linked
immunosorbent
assays
(ELISA)
showed
strong
an
vivo
carrageenan-induced
rat
paw
edema
model
revealing
significantly
reduced
inflammation.
Conclusions:
These
findings
highlight
potential
SNEDDS-enhanced
improving
outcomes.
Further
research
is
warranted
confirm
long-term
safety
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 512 - 512
Published: Feb. 5, 2025
The
rapid
development
of
nanotechnology
provides
new
approaches
to
manufacturing
food-related
nanoparticles
in
various
food
industries,
including
formulation,
functional
foods,
packaging,
and
quality
control.
Once
ingested,
will
immediately
adsorb
proteins
the
biological
fluids,
forming
a
corona
around
them.
Protein
coronas
alter
properties
nanoparticles,
their
toxicity,
cellular
uptake,
targeting
characteristics,
by
altering
aggregation
state.
In
addition,
conformation
function
enzymes
are
also
influenced
formation
protein
coronas,
affecting
digestion
products.
Since
inevitable
application
industries
subsequent
digestion,
comprehensive
understanding
is
essential.
This
systematic
review
introduces
explains
with
interactions
between
nanoparticles.
Furthermore,
potential
origin
that
migrate
from
packaging
materials
fates
gastrointestinal
tract
has
been
reviewed.
Finally,
this
explores
possible
effects
on
bioactive
compounds,
probiotics
prebiotics.
Understanding
mechanisms
crucial,
as
it
enables
design
tailored
delivery
systems
optimize
bioavailability
compounds.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11638 - 11638
Published: Oct. 30, 2024
Neuroinflammation,
characterised
by
the
activation
of
immune
cells
in
central
nervous
system
(CNS),
plays
a
dual
role
both
protecting
against
and
contributing
to
progression
neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD)
multiple
sclerosis
(MS).
This
review
explores
phosphoinositide
3-kinase
(PI3K),
key
enzyme
involved
cellular
survival,
proliferation,
inflammatory
responses,
within
context
neuroinflammation.
Two
PI3K
isoforms
interest,
PI3Kγ
PI3Kδ,
are
specific
regulation
CNS
cells,
microglia,
astrocytes,
neurons,
oligodendrocytes,
influencing
pathways,
Akt,
mTOR,
NF-κB,
that
control
cytokine
production,
cell
activation,
neuroprotection.
The
dysregulation
signalling
is
implicated
chronic
neuroinflammation,
exacerbation
diseases.
Preclinical
studies
show
promise
targeting
neuronal
disorders
using
inhibitors,
AS605240
(PI3Kγ)
idelalisib
(PI3Kδ),
which
have
reduced
inflammation,
microglial
death
vivo
models
AD.
However,
clinical
translation
these
inhibitors
faces
challenges,
including
blood-brain
barrier
(BBB)
permeability,
isoform
specificity,
long-term
safety
concerns.
highlights
therapeutic
potential
modulation
neuroinflammatory
identifying
gaps
current
research,
particularly
need
for
brain-penetrating
isoform-specific
inhibitors.
These
findings
underscore
importance
future
research
develop
targeted
therapies
can
effectively
modulate
activity
provide
neuroprotection
disorders.
Children,
Journal Year:
2024,
Volume and Issue:
11(2), P. 250 - 250
Published: Feb. 15, 2024
Familial
hypercholesterolemia
is
a
genetically
determined
disease
characterized
by
elevated
plasma
total
and
LDL
cholesterol
levels
from
the
very
first
years
of
life,
leading
to
early
atherosclerosis.
Nutritional
intervention
first-line
treatment,
complemented
with
nutraceuticals
drug
therapy
when
necessary.
Nutraceuticals
lipid-lowering
effect
have
been
extensively
studied
in
past
few
decades,
recently
included
international
guidelines
as
complement
nutritional
pharmacological
treatment
subjects
dyslipidemia.
In
this
review,
we
explore
current
interventions
for
dyslipidemia
childhood,
specific
focus
on
main
treating
severe
pediatric
patients.
Additionally,
briefly
describe
their
primary
mechanisms
action
highlight
advantages
risks
associated
use
childhood.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 28, 2024
Ferulic
acid
(FA),
a
phenolic
compound
abundant
in
the
cell
walls
of
seeds,
leaves,
and
roots
various
fruits,
vegetables,
cereals,
grains,
is
renowned
for
its
wide
range
biological
activities,
including
antioxidant,
anti-inflammatory,
antimicrobial,
anticancer
properties.
Despite
therapeutic
potential,
clinical
application
FA
hindered
by
challenges
such
as
poor
water
solubility,
limited
bioavailability,
rapid
metabolism,
instability
under
physiological
conditions.
To
address
these
issues,
nanotechnology
has
emerged
transformative
approach,
enhancing
FA's
pharmacokinetic
profile.
Various
nanoparticle-based
systems,
polymer-based
lipid-based
nanoparticles,
have
been
developed
to
encapsulate
FA.
These
systems
demonstrated
significant
improvements
stability,
with
studies
showing
enhanced
antioxidant
activity
controlled
release
profiles.
Further,
surface
engineering
nanoparticles
provides
targeted
drug/phytochemical
delivery
potential.
The
drugs/phytochemicals
significantly
enhances
efficacy
minimizes
systemic
side
effects.
This
review
explores
potential
FA,
limitations
application,
advancements
that
are
paving
way
effective
use.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(1), P. 25 - 25
Published: Jan. 3, 2025
Meningitis
is
the
acute
or
chronic
inflammation
of
protective
membranes,
surrounding
brain
and
spinal
cord,
this
inflammatory
process
spreads
throughout
subarachnoid
space.
The
traditional
drug
delivery
methods
pose
a
disadvantage
in
limiting
capacity
crossing
blood–brain
barrier
(BBB)
to
reach
central
nervous
system
(CNS).
Hence,
it
imperative
develop
novel
approaches
that
can
overcome
these
constraints
offer
efficient
therapy
for
meningitis.
Nanoparticle
(NP)-based
therapeutic
have
potential
address
limitations
such
as
penetrating
BBB
achieving
targeted
release
specific
cells
tissues.
This
review
highlights
recent
advancements
nanotechnology-based
approaches,
functionalized
polymeric
nanoparticles,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers,
nanoemulsions,
liposomes,
transferosomes,
metallic
NPs
treatment
Recently,
bionics
has
emerged
next-generation
technology
development
ideas
from
biological
principles,
structures,
interactions
neurological
neuroinfectious
diseases.
Despite
their
potential,
more
studies
are
needed
ensure
safety
efficacy
NP-based
systems
focusing
on
critical
aspects
toxicity,
immunogenicity,
pharmacokinetics.
Therefore,
addresses
current
strategies
innovative
nanoparticle
discusses
future
directions
meningitis
therapies.
