Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1395 - 1395
Published: April 21, 2025
Conjugated
linoleic
acid
(CLA)
is
a
bioactive
compound
known
for
its
anti-inflammatory,
anti-carcinogenic,
and
metabolic
effects,
with
growing
interest
in
role
supporting
bone
health.
Preclinical
studies,
particularly
those
involving
the
t10c12
isomer,
have
shown
that
CLA
can
enhance
mineral
density
(BMD)
by
enhancing
formation
reducing
resorption,
indicating
potential
as
therapeutic
agent
to
improve
However,
clinical
trials
yielded
inconsistent
results,
underscoring
difficulty
translating
animal
model
successes
human
applications.
A
major
challenge
CLA’s
low
water
solubility,
poor
absorption,
limited
bioavailability,
which
restrict
effectiveness.
To
address
these
issues,
nanoparticle-based
delivery
systems
been
proposed
stability,
resistance
oxidative
damage,
thereby
bioactivity.
Recent
studies
also
suggest
electrical
stimulation
stimulate
regeneration
promoting
cell
proliferation,
differentiation,
adherence
scaffolds.
This
review
explores
combined
use
of
supplementation
novel
approach
improving
health,
osteoporosis
management.
By
integrating
biological
effects
regenerative
stimulation,
this
multimodal
strategy
offers
promising
method
restoration,
significant
implications
applications
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(4), P. 464 - 464
Published: April 2, 2025
Natural
substances,
especially
those
derived
from
plants,
exhibit
a
diverse
range
of
therapeutic
benefits,
such
as
antioxidant,
anti-inflammatory,
anticancer,
and
antimicrobial
effects.
Nevertheless,
their
use
in
clinical
settings
is
frequently
impeded
by
inadequate
solubility,
limited
bioavailability,
instability.
Nanovesicular
carriers,
liposomes,
niosomes,
ethosomes,
transferosomes,
transethosomes,
cubosomes,
have
emerged
innovative
phytochemical
delivery
systems
to
address
these
limitations.
This
review
highlights
recent
developments
vesicular
nanocarriers
for
delivery,
emphasizing
preparation
techniques,
composition,
applications,
the
future
potential
systems.
Phytosomes,
along
with
key
advantages
various
are
extensively
described.
Various
vitro
vivo
characterization
techniques
utilized
evaluating
nanovesicular
carriers
summarized.
Completed
trials
patents
granted
nanovesicles
encapsulating
phytochemicals
designed
systemic
tabulated.
Phytochemical
via
faces
challenges
low
stability,
active
loading,
scalability
issues,
high
production
costs.
Additionally,
immune
clearance
regulatory
hurdles
hinder
application,
requiring
improved
carrier
design
formulation
techniques.
INDIAN DRUGS,
Journal Year:
2025,
Volume and Issue:
62(03), P. 26 - 37
Published: March 28, 2025
Hydrochlorothiazide,
a
poorly
soluble
and
also
permeable
drug
of
BCS
class
IV,
was
formulated
into
solid
lipid
nanoparticles
(SLNs)
using
the
microemulsion
method.
Precirol®
ATO
5,
Tween®
80
Kolliphor®
P
188
were
employed
as
lipid,
surfactant
co-surfactant,
respectively.
Optimization
23
factorial
design
explored
concentration
(A),
(B)
stirring
time
(C)
independent
variables,
particle
size
(Y1),
%
entrapment
efficiency
(Y2),
release
(Y3)
responses.
FTIR
DSC
demonstrated
drug-excipient
compatibility.
The
optimized
SLNs
showed
12-fold
water
solubility
increase,
94.75±0.0026
content,
91.23±0.29
efficiency,
35.06±0.0019
loading
sustained
zero
order
release.
A
permeation
study
revealed
enhanced
flux
(166.14±0.013µg
cm-2h)
permeability
coefficient
(83.07±0.031
cm
h-1)
compared
to
pure
drug.
SEM
uniform,
smooth
particles,
while
XRD
confirmed
SLN’s
amorphous
nature.
These
results
show
potential
significantly
enhance
hydrochlorothiazide’s
permeability.
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 489 - 489
Published: April 18, 2025
Nanoparticles
(NPs)
have
revolutionized
biomedical
and
pharmaceutical
applications
due
to
their
unique
physicochemical
properties.
However,
widespread
use
has
raised
concerns
regarding
potential
toxicity,
particularly
mediated
by
oxidative
stress
mechanisms.
This
redox
imbalance,
primarily
driven
the
overproduction
of
reactive
oxygen
species
(ROS),
plays
a
central
role
in
NP-induced
leading
cellular
dysfunction,
inflammation,
apoptosis,
genotoxicity.
Zebrafish
(Danio
rerio)
emerged
as
powerful
vivo
model
for
nanotoxicology,
offering
advantages
such
genetic
similarity
humans,
rapid
development,
optical
transparency,
allowing
real-time
monitoring
damage.
review
synthesizes
current
findings
on
zebrafish,
highlighting
key
toxicity
mechanisms
case
studies
involving
metallic
(gold,
silver,
copper),
metal
oxide
(zinc
oxide,
titanium
dioxide,
iron
oxide),
polymeric,
lipid-based
NPs.
The
influence
NP
properties,
size,
surface
charge,
functionalization,
responses
is
explored.
Additionally,
experimental
approaches
used
assess
ROS
generation,
antioxidant
enzyme
activity,
damage
biomarkers
zebrafish
models
are
examined.
In
addition
concerns,
antioxidant-modified
NPs
evaluated,
drug
delivery,
neuroprotection,
disease
therapeutics.
Notably,
show
that
curcumin-
quercetin-loaded
nanoparticles
enhance
defense
reduce
neurotoxicity
models,
demonstrating
promise
neuroprotective
therapies.
Furthermore,
cerium
nanoparticles,
which
mimic
catalase
SOD
enzymatic
shown
significant
efficacy
reducing
protecting
against
Challenges
zebrafish-based
need
standardized
methodologies,
future
directions
optimizing
design
minimize
stress-related
risks
also
discussed.
By
integrating
insights
from
mechanisms,
studies,
strategies,
this
supports
development
safer
more
effective
nanoparticle-based
therapies
while
addressing
challenges
toxicity.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1395 - 1395
Published: April 21, 2025
Conjugated
linoleic
acid
(CLA)
is
a
bioactive
compound
known
for
its
anti-inflammatory,
anti-carcinogenic,
and
metabolic
effects,
with
growing
interest
in
role
supporting
bone
health.
Preclinical
studies,
particularly
those
involving
the
t10c12
isomer,
have
shown
that
CLA
can
enhance
mineral
density
(BMD)
by
enhancing
formation
reducing
resorption,
indicating
potential
as
therapeutic
agent
to
improve
However,
clinical
trials
yielded
inconsistent
results,
underscoring
difficulty
translating
animal
model
successes
human
applications.
A
major
challenge
CLA’s
low
water
solubility,
poor
absorption,
limited
bioavailability,
which
restrict
effectiveness.
To
address
these
issues,
nanoparticle-based
delivery
systems
been
proposed
stability,
resistance
oxidative
damage,
thereby
bioactivity.
Recent
studies
also
suggest
electrical
stimulation
stimulate
regeneration
promoting
cell
proliferation,
differentiation,
adherence
scaffolds.
This
review
explores
combined
use
of
supplementation
novel
approach
improving
health,
osteoporosis
management.
By
integrating
biological
effects
regenerative
stimulation,
this
multimodal
strategy
offers
promising
method
restoration,
significant
implications
applications
