Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105782 - 105782

Published: June 27, 2024

Cognitive challenges and brain structure variations are common in autism spectrum disorder (ASD) but rarely explored middle-to-old aged autistic adults. deficits that overlap between young individuals elderlies with dementia raise an important question: does compromised cognitive ability during early development drive adults to be more vulnerable pathological aging conditions, or it protect them from further decline? To answer this question, we have synthesized current theoretical models of ASD conducted a systematic literature review (Jan 1, 1980 - Feb 29, 2024) meta-analysis summarize empirical studies on deviations We findings support different theories addressed study limitations future directions. This sheds light the poorly understood consequences question raised by community pave way for identify sensitive reliable measures best predict onset, progression, prognosis ASD.

Language: Английский

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Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

ABSTRACT Aging in autism is an emerging and under‐explored area of research. This systematic review provides a comprehensive overview studies on cognitive both structural functional cerebral aging autism. A search PubMed APA PsycInfo was conducted up to including January 2024. Two researchers independently screened identified relevant English (i.e., processing speed, executive function, working memory, episodic memory) and/or aspects) Study quality assessed using the QualSyst quantitative scale minimize bias. Thirty‐six met inclusion criteria, with nine focusing mechanisms, 19 eight addressing both. We examined profiles within context three hypotheses: accelerated aging, parallel safeguard hypothesis. The synthesis does not reveal consistent pattern respect any hypotheses, as results varied across methodology types (cross‐sectional vs. longitudinal) studies, even similar measures or function. highlights ongoing lack consensus this area, which may be attributed various internal external factors (e.g., participants age, co‐occurring conditions, lifestyle, reserve). Despite divergent findings, suggests that cross‐sectional autistic predominantly align In contrast, few longitudinal are only ones capable directly informing process, more Further research crucial understand how impact symptomatology, enabling tailored support.

Language: Английский

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Can bumetanide be a miraculous medicine for autism spectrum disorder: Meta-analysis evidence from randomized controlled trials

Research in autism spectrum disorders, Journal Year: 2024, Volume and Issue: 114, P. 102363 - 102363

Published: March 9, 2024

Language: Английский

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Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms[Letter]

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1797 - 1798

Published: Sept. 1, 2024

Language: Английский

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Link Between Alzheimer’s Disease, Obsessive-Compulsive Disorder, and ApoE Gene Polymorphisms [Response to Letter]

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1877 - 1878

Published: Oct. 1, 2024

Language: Английский

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