Inflammation in atherosclerosis: pathophysiology and mechanisms

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 11, 2024

Abstract Atherosclerosis imposes a heavy burden on cardiovascular health due to its indispensable role in the pathogenesis of disease (CVD) such as coronary artery and heart failure. Ample clinical experimental evidence has corroborated vital inflammation pathophysiology atherosclerosis. Hence, demand for preclinical research into atherosclerotic is horizon. Indeed, acquisition an in-depth knowledge molecular cellular mechanisms atherosclerosis should allow us identify novel therapeutic targets with translational merits. In this review, we aimed critically discuss speculate recently identified Moreover, delineated various signaling cascades proinflammatory responses macrophages other leukocytes that promote plaque end, highlighted potential targets, pros cons current interventions, well anti-inflammatory atheroprotective mechanisms.

Language: Английский

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Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116545 - 116545

Published: April 10, 2024

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress cyclic stretch, occur in various pathological conditions, play significant roles development progression CVDs. Mitochondria regulate physiological processes cardiac vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux redox control while promote cell death electron transport complex (ETC) related cellular response. Mounting evidence reveal stress-induced mitochondrial dysfunction plays a vital role pathogenesis many CVDs heart failure atherosclerosis. This review summarized functions cardiovascular system under (graphical abstract). The study can further understanding underlying mechanisms, identify potential therapeutic targets, aid novel treatments

Language: Английский

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Melatonin improves adverse vascular remodelling and redox homeostasis in monocrotaline-induced pulmonary arterial hypertension

Archives of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 2, 2025

This study explored the effects of melatonin on cardiac and vascular function, redox homeostasis in model PAH. Male Wistar rats were divided into: control (CTR), monocrotaline [MCT (60 mg/kg, single dose i.p)], + sildenafil SIL (50 mg/kg/day)], MEL (10 mg/kg/day)]. protocol lasted 21 days. Echocardiographic, morphometric, histological, reactivity, oxidative/nitrosative stress analyses performed. The reduced diastolic function AT/ET ratio MCT group partially attenuated by treatment (

Language: Английский

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Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology

Trends in Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Sex-Specific Association between Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes: A Post-Hoc Analysis of the SPRINT Trial

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 18, 2025

Systolic blood pressure time in target range (SBP TTR) is a novel metric for control. Previous studies have demonstrated an inverse association between SBP TTR and risks of cardiovascular events, but sex differences never been reported. This study aims to investigate the sex-specific relationship using data from Blood Pressure Intervention Trial (SPRINT). post hoc analysis included 8822 SPRINT participants with at least three follow-up systolic (SBP) measurements within first months. was calculated Rosendaal method linear interpolation. The primary endpoint major adverse cerebrovascular events (MACCE). Cox proportional hazards models restricted cubic splines (RCS) were used assess events. Women accounted 35.3% mean age 68.6 ± 9.5 years, having higher body mass index (p = 0.007) lower compared men < 0.001). In overall population women, each standard deviation (SD) increase associated reduced risk MACCE (adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.82-0.97; p 0.007, adjusted HR 0.85; CI 0.74-0.99; 0.039, respectively) acute decompensated heart failure 0.86; 0.73-0.99; 0.047, 0.68; 0.51-0.92; 0.011, respectively), while this not observed men. RCS indicated similar trend only when exceeded 39%. Additional adjustments variability yielded outcomes. demonstrates that failure, men, higher, underscoring necessity considering personalized management strategies. NCT01206062, https://www.clinicaltrials.gov/expert-search?term=NCT01206062.

Language: Английский

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The Impact of Liraglutide, a GLP-1 Receptor Agonist, on High Glucose-Induced Inflammation, Apoptosis, Oxidative Stress, and NLRP3 Signaling

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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A Novel 3D‐Printed Microfluidic Bioreactor With Electrospun Scaffold Integration as a Platform for Cardiovascular Tissue Engineering

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Cardiovascular diseases are one of the leading causes global mortality. Treatment methods such as bypass graft operations, while often successful, can fail in cases systemic disease or compliance mismatch. Tissue engineered vascular grafts may offer a potential solution, by means an implantable cell‐seeded scaffold that integrate into site. Modifications to cell culture environment, through physical modification structure, culturing cells dynamic fluidic have been shown alter cellular behavior. Herein, we combine these two approaches incorporating electrospun polycaprolactone scaffolds consisting smooth and modified fiber surface topographies within series novel 3D printed microfluidic bioreactors. The bioreactors successfully maintained viability human umbilical vein endothelial over 24‐h period, with static dimpled under indicating highest viability. An increase stiffness hydrophilicity is also noted comparison fibers. These results indicate both bioreactor system capable inducing variations response, thus warranting further investigation for advancement tissue engineering.

Language: Английский

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Flexible and multi-functional three-dimensional scaffold based on enokitake-like Au nanowires for real-time monitoring of endothelial mechanotransduction

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116610 - 116610

Published: July 27, 2024

Language: Английский

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What is in common between preeclampsia, HPS70 and medieval headwear? Part II. Serum HSP70 in superimposed preeclampsia: original study

Reproductive health of woman, Journal Year: 2024, Volume and Issue: 1, P. 32 - 41

Published: March 1, 2024

The objective: to investigate serum heat shock protein 70 (HSP70) concentration in pregnant women with chronic hypertension and superimposed preeclampsia. To assess the prospects of using HSP70 as a preeclampsia predictor.Materials methods. original prospective cohort single-center observational study included 105 34 healthy control group. Serum was measured via enzyme-linked immunosorbent assay. first measurement point at 28 weeks gestation, second 36 case absence or 29-35 If signs appeared later than weeks, additional not performed. Statistical analysis conducted EZR 1.55 software.Results. In group (105 hypertension), after delivery 30 patients had (superimposed subgroup) 75 persons no (chronic subgroup). (34 women) 3 (preeclampsia another 31 (healthy subgroup).Serum levels, obtained (28 weeks) statistically significantly different between three subgroups: vs. (p<0.01), (p<0.0001), (p<0.0001).Serum concentrations (36 preeclampsia) also significant difference for each pair subgroups (p<0.001). Given small number subgroup (3 women), it calculations.No levels points found subgroup. without complications, increased compared (p<0.0001). Even bigger growth occurred joining (p<0.0001).Conclusions. data suggest an corresponding term. Thus, is possible assume that plays role pathogenesis.The hypertension, gestational age determined. Therefore, can be argued has influence on course during pregnancy.No dependance level found. increase increasing most likely due progression hypertensive disorders and/or related conditions. highest observed addition preeclampsia.The use only predictor effective, given its non-specificity, but this indicator combination other markers promising requires further study.

Language: Английский

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A bypass flow model to study endothelial cell mechanotransduction across diverse flow environments

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101121 - 101121

Published: June 13, 2024

Disturbed flow is one of the pathological initiators endothelial dysfunction in intimal hyperplasia (IH) which commonly seen vascular bypass grafts, and arteriovenous fistulas. Various vitro disease models have been designed to simulate hemodynamic conditions found vasculature. Nonetheless, prior investigations encountered challenges establishing a robust disturbed model, primarily attributed complex bifurcated geometries distinctive dynamics. In present study, we aim address this gap by introducing an model capable inducing other hemodynamics patterns through pulsatile same model. To assess model's validity, employed computational fluid dynamics (CFD) compared morphology functions human umbilical venous cells (HUVECs) under those physiological or stagnant conditions. CFD analysis revealed generation within pinpointing specific location channel where effects were observed. High-content screening, single-cell morphological profile assessment, demonstrated that HUVECs area exhibited random orientation, features significantly distinct condition after two days exposure. Furthermore, exposed underwent extensive remodeling adherens junctions expressed higher levels cell activation markers conclusion, our provides platform for investigating associations between pattern diseases.

Language: Английский

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