Creation, Control, and Modeling of NV Centers in Nanodiamonds DOI Creative Commons
Pietro Aprà,

Nour Hanne Amine,

Adam Britel

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Sensing based on Nitrogen-Vacancy (NV) centers in nanodiamonds (NDs) offers significant potential across various applications. However, optimizing their quantum-optical properties remains challenging. This study focuses enhancing and controlling the optical of NV NDs through surface chemistry tuning proton beam irradiation. Systematic thermal oxidations were performed to investigate evolution chemical groups using IR spectroscopy influence photoluminescence PL decay measurements. Proton irradiation was explored over a wide range fluences (10^14 10^17 cm^-2) precisely control center concentration, identifying conditions that maximize creation emission intensity. Furthermore, charge state achieved by analyzing NV-/NV0 ratio with varying terminations concentrations. A novel predictive mathematical model developed evaluate efficiencies forming NV- NV0. Although tested specifically proton-irradiated NDs, this has broad applicability, representing advancement predicting outcomes ion-beam-based color generation diamond.

Language: Английский

Optimizing Polyethylene Glycol Coating for Stealth Nanodiamonds DOI Creative Commons
Edoardo Donadoni, Paulo Siani,

Simone Gambari

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Nanodiamonds (NDs) have emerged as potential candidates for versatile platforms in nanomedicine, offering unique properties that enhance their utility drug delivery, imaging, and therapeutic applications. To improve biocompatibility nanomedical applicability, NDs are coated with organic polymer chains, such poly(ethylene glycol) (PEG), which well known to prolong blood-circulating lifetime by reducing the surface adsorption of serum proteins. Theoretical simulations useful tools define, at atomic level, optimal parameters guide presentation coating chains biological environment interaction In this work, we perform atomistic molecular dynamics (MD) several PEGylated spherical ND models immersed a realistic physiological medium. particular, evaluate effect chain's terminal group, length, grafting density, core dimension on both structural PEG nanoconjugates aqueous phase. Moreover, investigate role played chemical nature material through comparative analysis titanium dioxide (TiO2) nanoparticle (NP). Among all evaluated, find chain NP key factors determining dynamic behavior nanosystems solution, whereas group only play marginal role. These can be strategically adjusted identify conditions enhanced clinical performance. Finally, prove prevents aggregation two particles. We believe computational study will provide valuable insights experimental community, supporting rational design polymer-coated inorganic NPs more efficient

Language: Английский

Citations

0
Designing functionalized nanodiamonds with hyaluronic acid–phospholipid conjugates for enhanced cancer cell targeting and fluorescence imaging capabilities DOI Creative Commons
Sofia Sturari, Ilaria Andreana, Pietro Aprà

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(24), P. 11610 - 11622

Published: Jan. 1, 2024

Nanomedicine aims to develop smart approaches for treating cancer and other diseases improve patient survival quality of life. Novel nanoparticles as nanodiamonds (NDs) represent promising candidates overcome current limitations. In this study, NDs were functionalized with a 200 kDa hyaluronic acid-phospholipid conjugate (HA/DMPE), enhancing the stability in water-based solutions selectivity cells overexpressing specific HA cluster determinant 44 (CD44) receptors. These characterized by diffuse reflectance Fourier-transform infrared spectroscopy, Raman photoluminescence confirming efficacy functionalization process. Scanning electron microscopy was employed evaluate size distribution dry particles, while dynamic light scattering zeta potential measurements utilized ND behavior medium. Furthermore, biocompatibility uptake mediated CD44 receptors three different models human adenocarcinoma assessed performing cytofluorimetric assay confocal microscopy. HA-functionalized demonstrated advantage active targeting presence expressing on surface, suggesting higher drug delivery tumors over non-tumor tissues. Even CD44-poorly cancers could be targeted NDs, thanks their good passive diffusion within cells.

Language: Английский

Citations

3
Effects of Thermal Oxidation and Proton Irradiation on Optically Detected Magnetic Resonance Sensitivity in Sub-100 nm Nanodiamonds DOI Creative Commons
Pietro Aprà,

G. Zanelli,

Elena Losero

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

In recent decades, nanodiamonds (NDs) have emerged as innovative nanotools for weak magnetic fields and small temperature variation sensing, especially in biological systems. At the basis of use NDs quantum sensors are nitrogen-vacancy center lattice defects, whose electronic structures influenced by surrounding environment can be probed optically detected resonance technique. Ideally, limiting NDs' size much possible is important to ensure higher biocompatibility provide spatial resolution. However, reduction typically worsens sensing properties. This study endeavors obtain sub-100 nm suitable used sensors. Thermal processing surface oxidations were performed purify control their chemistry size. Ion irradiation techniques also employed increase concentration centers. The impact these processes was explored terms (diffuse reflectance infrared Fourier transform spectroscopy), structural optical properties (Raman photoluminescence dimension (atomic force microscopy measurements), sensitivity. Our results demonstrate how optimization defect density enhancement reduce detrimental reduction, opening possibility minimally invasive high-performance physical quantities environments with nanoscale

Language: Английский

Citations

0
Performance and mechanism of the structure formation and physical-mechanical properties of concrete by modification with nanodiamonds DOI
Alexey N. Beskopylny, Sergey A. Stel’makh, Evgenii M. Shcherban’

et al.

Construction and Building Materials, Journal Year: 2024, Volume and Issue: 452, P. 138994 - 138994

Published: Nov. 1, 2024

Language: Английский

Citations

2
Universality of hydroxyl radical generation in irradiated nanoenhancer suspensions: Vital role of concentration DOI Creative Commons
Changfeng Yang,

Bowen Zhang,

Xiaoqian Lin

et al.

AIP Advances, Journal Year: 2024, Volume and Issue: 14(5)

Published: May 1, 2024

Concentration plays an essential role in generating hydroxyl radicals irradiated nanoenhancer suspensions. In this paper, we used coumarin-3-carboxylic acid as a radical-specific probe to investigate the radical production of different concentration nanodiamonds (NDs) and CeO2 NPs phosphate-buffered saline under x-ray irradiation. NDs significantly enhanced production, maximum enhancement was observed at 10 µg/ml, with factor 1.398 ± 0.262. can increase scavenge ranges, lowest highest factors 0.623 0.069 1.738 0.264, respectively. We tested hydrodynamic diameter various concentrations explore effect further. found that increasing concentration, there might be factors, such recombination nanoparticle agglomeration, lead changes factor. Based on data from previous present studies, experimental results indicate is for generation suspensions ionizing radiation. also provide possible mechanisms enhancing by nanoenhancers water radiation decrease high nanoenhancers.

Language: Английский

Citations

1
Creation, Control, and Modeling of NV Centers in Nanodiamonds DOI Creative Commons
Pietro Aprà,

Nour Hanne Amine,

Adam Britel

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Sensing based on Nitrogen-Vacancy (NV) centers in nanodiamonds (NDs) offers significant potential across various applications. However, optimizing their quantum-optical properties remains challenging. This study focuses enhancing and controlling the optical of NV NDs through surface chemistry tuning proton beam irradiation. Systematic thermal oxidations were performed to investigate evolution chemical groups using IR spectroscopy influence photoluminescence PL decay measurements. Proton irradiation was explored over a wide range fluences (10^14 10^17 cm^-2) precisely control center concentration, identifying conditions that maximize creation emission intensity. Furthermore, charge state achieved by analyzing NV-/NV0 ratio with varying terminations concentrations. A novel predictive mathematical model developed evaluate efficiencies forming NV- NV0. Although tested specifically proton-irradiated NDs, this has broad applicability, representing advancement predicting outcomes ion-beam-based color generation diamond.

Language: Английский

Citations

1