Life, Journal Year: 2024, Volume and Issue: 14(5), P. 594 - 594
Published: May 7, 2024
Urodelean amphibians can regenerate the tail and spinal cord (SC) maintain this ability throughout their life. This clearly distinguishes these animals from mammals. The phenomenon of SC regeneration is based on capability cells involved in to dedifferentiate, enter cell cycle, change (or return pre-existing) phenotype during de novo organ formation. second critical aspect successful mutual molecular regulation by tissues, which apical wound epidermis are leaders. Molecular regulatory systems include signaling pathways components, inflammatory factors, ECM molecules, ROS, hormones, neurotransmitters, HSPs, transcriptional epigenetic etc. control, carried out networks feedback principle, recruits mechanisms used embryogenesis accompanies all stages regeneration, moment damage completion morphogenesis patterning its structures. late effects external factors them have been poorly studied. A new model for addressing issue herein proposed. data summarized review contribute understanding a wide range fundamentally important issues regenerative biology tissues organs vertebrates including humans.
Language: Английский