Evolving Strategies in Cervical Cancer Therapy: A Comprehensive Review Navigating From Molecular Insights to Regulatory Challenges DOI

A Thejas,

T Shailesh,

Hemanth Kumar S

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106568 - 106568

Published: Dec. 1, 2024

Language: Английский

The Evolving Landscape of Cervical Cancer: Breakthroughs in Screening and Therapy Through Integrating Biotechnology and Artificial Intelligence DOI
Raghu Aswathy, Sundaravadivelu Sumathi

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Language: Английский

Citations

4
Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment DOI

Raffaella Villa,

Ya‐Ping Shiau,

Sohaib Mahri

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: May 7, 2025

Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles shown promise enhancing drug delivery improving activation, with for numerous modifications tailor them specific environments or targets. Integrating nanoplatforms offers a promising avenue overcome these hurdles, treatment outcomes reducing adverse effects. By delivery, targeting, modulation, can unlock full of cancer immunotherapy. This review explores role addressing immunotherapy outcomes, examining various types nanoplatforms. Understanding mechanisms immunomodulation through nanoplatform deliveries is crucial. We discuss how interact tumor microenvironment, modulate tumor-associated macrophages regulatory T cells, activate cells directly, enhance antigen presentation, promote immunological memory. Further benefits include combination approaches integrating chemotherapy, radiotherapy, phototherapy. Immunotherapy relatively new approach, but clinical studies already utilize nanoplatform-based results. aims provide insights into pave way more effective personalized strategies.

Language: Английский

Citations

0
Advanced Smart Nanomaterial-Based System for Treatment of Cervical Cancer: A Systematic Review DOI
Bedanta Bhattacharjee,

Sandhanam Kuppusamy,

Nayan Ranjan Ghose Bishwas

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106327 - 106327

Published: Oct. 1, 2024

Language: Английский

Citations

1
Construction of BSA-ZnO&Quercetin based multifunctional bionic self-assembly system and their antibacterial mechanism study DOI

Shuxian Hou,

Ye Hong,

Jihua Shang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114288 - 114288

Published: Oct. 5, 2024

Language: Английский

Citations

0
Preparation and characterization of fetal rat renal cell peptides for their antitumor activity DOI Creative Commons
Zhe Zhang, Yuan Cao,

Jing Du

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Background The therapeutic efficacy of traditional chemotherapies and advanced targeted therapies is unsatisfactory due to systemic adverse effects. Bioactive peptides are attractive reagents because their high antitumor activity safety profiles. Currently, bioactive can be derived from various organisms. This study aimed prepare characterize fetal rat renal cell (RCPs) for activities in vitro. Methods kidneys were dissected SD rats digested with collagenase obtain cells, which further trypsin, alkaline protease, papain, protamex, respectively. Following filtration 3 10-K filters, the enzyme-digested products measured protein concentrations tested cytotoxicity against MCF-7 cells. individual enzyme predicted using http://distilldeep.ucd.ie/PeptideRanker. top synthesized different types tumor cells vitro by CCK-8 assays. Finally, IC50 values calculated accuracy was estimated ROC curve. Results Digestion resulted epithelial morphology digestion or protease led percentages a molecular weight < 3k, 3-10k, > 10k. Preliminary screening revealed that treatment but not protease-digested 3k reduced viability dose-dependent manner. Functionally, many ten (RCPs 1–10) synthesized. Interestingly, RCP1, 5, 6 displayed preferable human cancer MCF-7, A549, HCT-116, Hela, HepG2, SGC-7901 time- dose-dependent. Conclusion RCPs prepared embryonic potent preferably These may valuable malignant tumors.

Language: Английский

Citations

0
Evolving Strategies in Cervical Cancer Therapy: A Comprehensive Review Navigating From Molecular Insights to Regulatory Challenges DOI

A Thejas,

T Shailesh,

Hemanth Kumar S

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106568 - 106568

Published: Dec. 1, 2024

Language: Английский

Citations

0