Odorant receptor co-receptors affect expression of tuning receptors in Drosophila DOI Creative Commons
Long Teng, Pratyajit Mohapatra, Sydney Ballou

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 20, 2024

Insects detect odorants using two large families of heteromeric receptors, the Odorant Receptors (ORs) and Ionotropic (IRs). Most OR IR genes encode odorant-binding “tuning” subunits, whereas four ( Orco , Ir8a Ir25a Ir76b ) co-receptor subunits required for receptor function. Olfactory neurons are thought to degenerate in absence ants bees, limited data suggest this may happen some olfactory Drosophila fruit flies as well. Here, we thoroughly examined role co-receptors on neuron survival . Leveraging knowledge that classes defined by expression different tuning used antennal transcriptomes a proxy distinct classes. Consistent with degeneration, many OR-family receptors is decreased mutants relative controls, transcript loss progressive age. The effects highly receptor-dependent, transcripts nearly eliminated others unaffected. Surprisingly, further studies revealed reduced generally survive mutant flies. Furthermore, there little apoptosis or neuronal antenna these We went investigate family similar approaches found but not As mutants, Ir8a-dependent mostly endure despite near-absent associated receptors. Finally, differential analysis identify other whose changed mutants. Taken together, our indicate odorant necessary maintaining at mRNA level. Further, most persist suggesting impact vary across insect species.

Language: Английский

Functional Characterization of Peripheral Neurons and a Receptor Recognizing Sex Pheromones in Hyphantria cunea (Erebidae) DOI

Guiqiu Di,

Zicong Li,

Weichao Ma

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(33), P. 18353 - 18364

Published: Aug. 6, 2024

(Lepidoptera: Erebidae) is difficult and costly to control as a quarantine pest found globally. Sex pheromone trapping an effective measure for its population monitoring control; however, the peripheral neural mechanism of sex recognition in

Language: Английский

Citations

1
Odorant receptor co-receptors affect expression of tuning receptors in Drosophila DOI Creative Commons
Long Teng, Pratyajit Mohapatra, Sydney Ballou

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 20, 2024

Insects detect odorants using two large families of heteromeric receptors, the Odorant Receptors (ORs) and Ionotropic (IRs). Most OR IR genes encode odorant-binding “tuning” subunits, whereas four ( Orco , Ir8a Ir25a Ir76b ) co-receptor subunits required for receptor function. Olfactory neurons are thought to degenerate in absence ants bees, limited data suggest this may happen some olfactory Drosophila fruit flies as well. Here, we thoroughly examined role co-receptors on neuron survival . Leveraging knowledge that classes defined by expression different tuning used antennal transcriptomes a proxy distinct classes. Consistent with degeneration, many OR-family receptors is decreased mutants relative controls, transcript loss progressive age. The effects highly receptor-dependent, transcripts nearly eliminated others unaffected. Surprisingly, further studies revealed reduced generally survive mutant flies. Furthermore, there little apoptosis or neuronal antenna these We went investigate family similar approaches found but not As mutants, Ir8a-dependent mostly endure despite near-absent associated receptors. Finally, differential analysis identify other whose changed mutants. Taken together, our indicate odorant necessary maintaining at mRNA level. Further, most persist suggesting impact vary across insect species.

Language: Английский

Citations

0