Identifying the quality markers and optimizing the processing of Gastrodiae rhizoma to treat brain diseases DOI Creative Commons

Yan Fu,

Qingqing Xu,

Jinqiang Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Background Gastrodiae rhizoma (GR) refers to the dried tuber of Gastrodia elata Bl. and has been used for many centuries treat brain diseases, such as Alzheimer’s disease, major depressive disorder, cerebral ischemia. However, processing GR is complex varied, resulting in unstable clinical treatment effects. The protocols significantly affect active ingredients curative effects GR. We can optimize by identifying quality markers diseases. Methods Fresh tubers G. were processed under eight different protocols, their contents potentially bioactive compounds compared using liquid chromatography mass spectrometry screen potential through stoichiometric analysis. targeting ischemia identified network pharmacology, neuroprotective these components validated simulated docking likely protein targets. Finally, a fit degree analysis was carried out composition ratios proportions disease component value, therapeutic methods on outlined clearly. Results 32 screened 13 GR, which five (galactinol, glucosyringic acid, parishins C E, S-(4-hydroxybenzyl)-glutathione) showed efficacy against all three Furthermore, steaming microwave-drying during treating Conclusion Processing may also impact its effectiveness Accordingly, optimizing correspond purposes improve

Language: Английский

Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review DOI Creative Commons

Radhakrishna Reddi Sree,

Manjunath Kalyan,

Nikhilesh Anand

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5148 - 5171

Published: Feb. 3, 2025

Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative affecting mostly the elderly population. The main pathological features of AD are extracellular Aβ plaques generated by APP cleavage through amyloidogenic pathway, intracellular neurofibrillary tangles (NFT) resulting from hyperphosphorylated tau proteins, and cholinergic neurodegeneration. However, actual causes unknown, but several studies suggest hereditary mutations in PSEN1 -2, APOE4, APP, TAU genes major perpetrators. In order to understand etiology pathogenesis AD, various hypotheses proposed. These include following hypotheses: amyloid accumulation, tauopathy, inflammation, oxidative stress, mitochondrial dysfunction, glutamate/excitotoxicity, deficiency, gut dysbiosis. Currently approved therapeutic interventions donepezil, galantamine, rivastigmine, which cholinesterase inhibitors (ChEIs), memantine, N-methyl-d-aspartate (NMDA) antagonist. treatment strategies focus on only symptomatic management attenuating symptoms not regeneration neurons or clearance Tau. This review focuses pathophysiology, novel targets, disease-altering treatments such as α-secretase modulators, active immunotherapy, passive natural antioxidant products, nanomaterials, antiamyloid therapy, aggregation inhibitors, transplantation fecal microbiota stem cells, microtubule stabilizers that clinical trials still under investigation.

Language: Английский

Citations

1
Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review DOI Creative Commons
Ana Isabel Beltrán-Velasco

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 128 - 128

Published: Feb. 13, 2025

Background: Brain glycogen is imperative for neuronal health, as it supports energy demands and metabolic processes. This review examines the pathways involved in storage utilization central nervous system, emphasizing their role both physiology pathology. It explores how alterations metabolism contribute to neurological disorders, including neurodegenerative diseases, epilepsy, conditions while highlighting bidirectional interaction between neurons glia maintaining brain homeostasis. Methods: A comprehensive search of articles published 2015 2025 was conducted using following databases: ScienceDirect, Scopus, Wiley, Web Science, Medline, PubMed. The selection relevant studies based on focus its conditions, with that did not meet inclusion criteria being excluded. Results: processes are subject rigorous regulation by astrocyte-neuron interactions, thereby ensuring homeostasis availability. dysregulation mobilization has been implicated development synaptic dysfunction, excitotoxicity, neurodegeneration a variety disorders. For instance, aberrant accumulation diseases such Lafora disease associated severe neurodegeneration, impaired shown exacerbate deficits Alzheimer's epilepsy. Conclusions: Targeting represents promising approach therapeutic intervention However, translation these strategies human models remains challenging, particularly regard long-term safety specificity glycogen-targeted therapies.

Language: Английский

Citations

0
The Potential of Metabolomics to Find Proper Biomarkers for Addressing the Neuroprotective Efficacy of Drugs Aimed at Delaying Parkinson’s and Alzheimer’s Disease Progression DOI Creative Commons
Rafael Franco, Claudia Garrigós, Jaume Lillo

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1288 - 1288

Published: July 31, 2024

The first objective is to highlight the lack of tools measure whether a given intervention affords neuroprotection in patients with Alzheimer’s or Parkinson’s diseases. A second aim present primary outcome measures used clinical trials cohorts neurodegenerative final discuss metabolomics using body fluids may lead discovery biomarkers neuroprotection. Information on related and disease registered since 2018 was collected. We analysed type selected assess efficacy, not terms since, as stated aims, there yet any marker Proteomic approaches plasma CSF have been proposed. PET could estimate extent lesions, but progression does necessarily correlate change tracer uptake. propose some alternatives based considering metabolome. new opportunity opens because impressive technological advances that allow detection, among others, metabolites mitochondrial function structure serum and/or cerebrospinal fluid; differentially concentrated can become reliable

Language: Английский

Citations

2
4,4′-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer’s disease DOI Creative Commons

Xingzhi Yu,

Jie Tao,

Tian Xiao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 30, 2024

is a widely used medicinal and edible herb with rich chemical composition. Moreover, prescriptions containing

Language: Английский

Citations

1
Genetic diversity and construction of a core collection in Chinese Gastrodia elata germplasm resources DOI
Mei Yang, Lan Yang,

Jingmin Hai

et al.

Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 337, P. 113595 - 113595

Published: Aug. 29, 2024

Language: Английский

Citations

1
Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics DOI Creative Commons
Lei Shi, Chao Guo, Min Fang

et al.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Plant microRNAs (miRNAs) are small non-coding RNA molecules that usually negatively regulate gene expression at the post-transcriptional level. Recent data reveal plant miRNAs not limited to individual plants but can transfer across different species, allowing for communication with plant, animal, and microbial worlds in a cross-kingdom approach. This review discusses differences miRNA biosynthesis between animals summarizes current research on cross-species regulatory effects of nearby plants, pathogenic fungi, insects, which be applied crop disease pest resistance. In particular, this highlights latest findings regarding function transboundary regulation human expression, may greatly expand clinical applicability as intriguing tools natural plant-based medicinal products future.

Language: Английский

Citations

1
Pan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers DOI Creative Commons
Leying Guan,

Rong Zeng,

Yi Chen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Polyomavirus enhancer activator 3 (PEA3), an ETS transcription factor, has been documented to regulate the development and metastasis of human cancers. Nonetheless, a thorough analysis examining relationship between PEA3 subfamily members tumour development, prognosis, microenvironment (TME) across various cancer types not yet conducted. The expression profiles prognostic significance were evaluated using data from GEO, TCGA, PrognoScan databases, in conjunction with COX regression analyses Kaplan-Meier Plotter. Furthermore, relationships expression, stemness scores, tumor microenvironments, immune subtypes, drug susceptibility multiple explored. We found that ETV1, ETV4 ETV5 are highly expressed cancer, their biological functions synergistic. In Cancer Genome Atlas, genes be associated prognosis cancers such as Lung adenocarcinoma (LUAD), Liver hepatocellular carcinoma (LIHC), etc., marked worse at different endpoints. addition, it was significantly correlated stromal scores pan-cancer, also RNA score DNA pan-cancer. Expression levels correlate subtypes LIHC, LUAD, squamous cell carcinoma. variety drugs positive negative associations ETV5. These findings elucidate role gene biomarker for carcinogenesis progression, offering valuable insights future research into potential therapeutic target types.

Language: Английский

Citations

1
Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer DOI

Haihong Hu,

Hongxia Zhu,

Wendi Zhan

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(6), P. 1047 - 1068

Published: April 15, 2024

Language: Английский

Citations

0
Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases DOI
Vibha Pandey, Debasis Chakrabarty

Published: Jan. 1, 2024

Language: Английский

Citations

0
A New Frontier in Phytotherapy: Harnessing the Therapeutic Power of Medicinal Herb-derived miRNAs DOI
Ya‐Long Feng

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(38), P. 3009 - 3017

Published: Aug. 20, 2024

: Medicinal herbs have been utilized in the treatment of various pathologic conditions, including neoplasms, organ fibrosis, and diabetes mellitus. However, precise pharmacological actions plant miRNAs animals remain to be fully elucidated, particularly terms their therapeutic efficacy mechanism action. In this review, some important from foods medicinal are presented. Plant exhibit a range properties, such as anti-cancer, anti-fibrosis, anti-viral, anti-inflammatory effects, neuromodulation, among others. These results not only demonstrated cross-species regulatory effect, but also suggested that bioactive components. This shows promising prospect for used drugs. Here, properties underlying mechanisms highlighted, which can provide new insights clarifying suggest way developing

Language: Английский

Citations

0