Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 5, P. 100058 - 100058
Published: Dec. 17, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3562 - 3562
Published: March 21, 2024
Exosomes are extracellular vesicles of endosomal origin, ranging from 30 to 150 nm in diameter, that mediate intercellular transfer various biomolecules, such as proteins, lipids, nucleic acids, and metabolites. They modulate the functions recipient cells participate diverse physiological pathological processes, immune responses, cell-cell communication, carcinogenesis, viral infection. Stem (SCs) pluripotent or multipotent can differentiate into cell types. SCs also secrete exosomes, which exhibit remarkable therapeutic potential for diseases, especially field regenerative medicine. For example, exosomes derived mesenchymal stem (MSCs) contain miRNAs ameliorate endocrine disorders, diabetes cancer. (sc-exos) may offer similar advantages SCs, but with reduced risks challenges. Sc-exos have lower tumorigenicity, immunogenicity, infectivity. deliver drugs more efficiently penetrate deeper tissues. In this review, we provide an overview recent advances sc-exos their applications We elucidate how biological effects depend on molecular composition. address current challenges future directions using sc-exos.
Language: Английский
Citations
22
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 2, 2024
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing heavy economic burden on patients and society. B lymphocytes, group immune cells associated humoral immunity, have been shown to be involved in the pathogenesis PD. However, causal relationship potential pathogenic effects cell PD remain unclear. Based three core hypotheses Mendelian randomization (MR) study, we explored associations between 190 B-cell immunological traits 482,730 European individuals (Ncase = 33,674, Ncontrol 449,056) from genome wide association studies by means two-sample bidirectional MR method. The inverse‑variance weighted method was selected as main approach when conducting analysis. Finally, results were verified heterogeneity horizontal pleiotropy analyses. Five phenotypes nominally at significance threshold P < 0.05. Concretely, IgD + CD38− %lymphocyte (OR 1.052, 95% CI 1.001–1.106, 0.046), CD20 IgD− CD24− 1.060, 1.005–1.117, 0.032), CD38 IgD+ 1.113, 1.028–1.206, 0.009), BAFF-R CD20− 1.093, 1.010–1.184, 0.027) identified risk factors for Instead, Plasma Blast-Plasma Cell 0.894, 0.802–0.996, 0.043) proved protective. there no statistically significant correlation after Bonferroni correction. reverse negative, avoiding effects. Eventually, stable across several sensitivity Briefly, our study might demonstrate key factor Further are warranted clarify early identification immunotherapeutic development patients.
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116443 - 116443
Published: March 20, 2024
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway characterized by progressive respiratory difficulties. It has high incidence and disability rate worldwide. However, currently there still lack of highly effective treatment methods for COPD, only symptom relief possible. Therefore, an urgent need to explore new options. Almost all cells can secrete extracellular vesicles (EVs), which participate in many physiological activities transporting cargoes are associated with the pathogenesis various diseases. Recently, scholars have extensively studied relationship between COPD EVs, strongly demonstrated significant impact EVs from different sources on occurrence development COPD. good starting point opportunity diagnosis In this review, we mainly describe current mechanisms also diagnosis, prognosis, treatment. At same time, introduce some therapy based EVs. hoped that article provide ideas future research contribute precision medicine.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10401 - 10401
Published: Sept. 27, 2024
Extracellular vesicles (EVs) are natural carriers of biomolecules that play a crucial role in cell-to-cell communication and tissue homeostasis under normal pathological conditions, including inflammatory diseases cancer. Since the discovery pro-regenerative immune-modulating properties EVs, EV-based therapeutics have entered clinical trials for conditions such as myocardial infarction autoimmune diseases, among others. Due to their unique advantages—such superior bioavailability, substantial packaging capacity, ability traverse biological barriers—EVs regarded promising platform targeted drug delivery. However, achieving sufficient accumulation therapeutic agents at target site necessitates larger quantity EVs per dose compared using standalone drugs. This challenge can be addressed by administering doses increasing dosage administration, or enhancing selective cells. In this review, we will discuss methods improve isolation purification approaches enhance cargo packaging—including proteins, RNAs, small-molecule drugs—and technologies displaying targeting ligands on surface facilitate improved targeting. Ultimately, guide applied development novel classes overcoming existing technological challenges.
Language: Английский
Citations
4
Small Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Extracellular vesicles (EVs) are lipid bilayer nanoparticles naturally released from cells, playing a crucial role in intercellular communication. They modulate gene expression and regulate physiological pathological processes, including acute lung injury (ALI) respiratory distress syndrome (ARDS). Research has shown that EVs contain variety of active components, biocompatible small size, do not trigger immune rejection, making the infusion exogenous promising therapeutic tool. With further research, engineering strategies have been proposed to enhance clinical potential EVs. These involve modifying either donor cells secrete or themselves can be engineered circumvent limitations native In this review, an overview biological properties is provided current treating ALI/ARDS, along with latest research findings, summarized. The challenges opportunities for translation as novel tool also discussed, offering new insights into treatment ALI/ARDS using EV technology.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Cell membrane coating has emerged as a promising strategy for the surface modification of biomaterials with biological membranes, serving cloak that can carry more functions. The cloaked inherit diverse intrinsic biofunctions derived from different cell sources, including enhanced biocompatibility, immunity evasion, specific targeting capacity, and immune regulation regenerative microenvironment. characteristics biomimicry biointerfacing have demonstrated versatility technology on variety biomaterials, thus, furthering research into wide range biomedical applications clinical translation. Here, preparation coatings is emphasized, sizes coated nanoscale to macroscale well engineering strategies introduce additional are summarized. Subsequently, utilization biomimetic membrane-cloaked in discussed, drug delivery, imaging phototherapy, cancer immunotherapy, anti-infection detoxification, implant modification. In conclusion, latest advancements preclinical studies, along multiple benefits membrane-coated nanoparticles (NPs) systems, elucidated.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0
Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 5, P. 100058 - 100058
Published: Dec. 17, 2024
Language: Английский
Citations
0