Nuclear Medicine and Biology, Journal Year: 2024, Volume and Issue: 138-139, P. 108967 - 108967
Published: Oct. 24, 2024
Language: Английский
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: Jan. 2, 2025
Background Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-protective effects in patients with DKD, independent their glucose-lowering effects. However, underlying mechanism remains unclear. This study hypothesized SGLT2i could alleviate diabetic injury by inhibiting ferroptosis and explored its potential mechanisms.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062
Published: Aug. 30, 2024
Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.
Language: Английский
Citations
5
The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 132, P. 109693 - 109693
Published: June 15, 2024
Language: Английский
Citations
4
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106836 - 106836
Published: Feb. 1, 2025
Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality disability rates. At present, the incidence of IS increasing annually, with notable trend towards younger affected individuals. Recent discoveries concerning "gut-brain axis" have established connection between gut brain. Numerous studies revealed intestinal microbes play crucial role in onset, progression, outcomes IS. They are involved entire pathophysiological process through mechanisms such as chronic inflammation, neural regulation, metabolic processes. Although numerous explored relationship microbiota, comprehensive analyses specific microbiota relatively scarce. Therefore, this paper provides an overview typical changes following investigates microorganisms context. Additionally, it presents analysis post-stroke microbiological therapy diet. The aim to identify potential microbial targets for therapeutic intervention, well highlight benefits therapies significance dietary management. Overall, seeks provide key strategies treatment management IS, advocating healthy diets health programs Meanwhile, may offer new perspective on future interdisciplinary development neurology, microbiology nutrition.
Language: Английский
Citations
0
Human Cell, Journal Year: 2025, Volume and Issue: 38(2)
Published: Feb. 20, 2025
Abstract High glucose leads to cellular damage and dysfunction in the retina. Dietary interventions, including use of ketogenic diets, have been explored for their potential reduce adverse effects hyperglycemia. β-Hydroxybutyrate (BHB), a ketone body, has immune anti-inflammatory properties. This study aims investigate whether BHB ameliorates harmful induced by high ARPE-19 cells, model retinal pigment epithelium. We investigated and/or on viability, migration, colony-forming ability, cell cycle progression cytokine production. Our data indicate that significantly reduces viability cells with no significant changes apoptosis or autophagy, while inducing cytostasis. On other hand, exerts protective effect under hyperglycemic conditions improving alleviating glucose-induced arrest. Additionally, treatment affects expression IL-8 IL-17α, as well MCP-1, modulating inflammatory response, migration wound healing. In conclusion, this highlights role against detrimental cells. These findings support bodies mitigating damage. Future research will be critical translate these clinical practice metabolic diseases.
Language: Английский
Citations
0
Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)
Published: Feb. 28, 2025
Abstract Tay-Sachs disease is a rare lysosomal storage disorder caused by β-Hexosaminidase A enzyme deficiency causing abnormal GM2 ganglioside accumulation in the central nervous system. triggers chronic neuroinflammation due to neurodegeneration-based astrogliosis and macrophage activity with increased expression level of Ccl2 cortex recently generated mouse model Hexa-/-Neu3-/- . Propagermanium blocks neuroinflammatory response induced Ccl2, which highly expressed astrocytes microglia. The ketogenic diet has broad potential usage neurological disorders, but knowledge impact on Tay-Sach limited. This study aimed display effect combining propagermanium treatment model. mice were placed into following groups: (i) standard diet, (ii) (iii) propagermanium, (iv) propagermanium. RT-PCR immunohistochemistry analyzed markers. Behavioral analyses also applied assess phenotypic improvement. Notably, levels neuroinflammation-related genes reduced 140-day-old compared deficient ( Hexa-/- ) after combined treatment. Immunohistochemical analysis displayed correlated results RT-PCR. Our data suggest implement reduce inflammation other diseases.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Alzheimer's disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood metabolome, less is known about their impact in brain. Here we investigated impacts aging brain metabolic profiles across lifespan, using human APOE-targeted replacement mice. Biocrates P180 targeted metabolomics platform used measure a broad range metabolites probing various processes. In all report changes acylcarnitines, biogenic amines, amino acids, phospholipids sphingomyelins during aging. The decreased ratio medium long-chain acylcarnitine suggests reduced level fatty acid β-oxidation thus possibility mitochondrial dysfunction as these animals age. Additionally, APOE2/2 mice had altered branch-chain acids (BCAA) profile increased downstream metabolite C5 acylcarnitine, indicating branched-chain utilization TCA cycle better energetic endowed this protective genotype. We results dorsolateral prefrontal cortex metabolomic data from Religious Orders Study/Memory Aging Project, found that carriers APOE2/3 lower markers impaired BCAA katabolism, including tiglyl carnitine, methylmalonate 3-methylglutaconate. summary, suggest potential involvement nominate humanized mouse models for further study AD, aging, energy. have previously shown plasma be associated incident dementia, higher levels AD pathology cognitive impairment. Those findings together our current could potentially explain AD-protective enabling energy decline β-oxidation.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1060 - 1060
Published: March 18, 2025
Background/Objectives: Epigenetic clocks have emerged as a tool to quantify biological age, providing more accurate estimate of an individual’s health status than chronological helping identify risk factors for accelerated aging and evaluating the reversibility therapeutic strategies. This study aimed evaluate potential association between epigenetic acceleration age obesity, well determine whether nutritional interventions body weight loss could slow down this acceleration. Methods: Biological was estimated using three (Horvath (Hv), Hannum (Hn), Levine (Lv)) based on leukocyte methylome analysis individuals with normal (n = 20), obesity 24), patients following VLCKD 10). We analyzed differences in estimates, relationship impact VLCKD. Correlations were assessed acceleration, BMI, various metabolic parameters. Results: Analysis revealed (Hv +3.4(2.5), Hn +5.7(3.2), Lv +3.9(2.7)) compared slight deceleration weight. correlated BMI (p < 0.0001). Interestingly, showed both ketosis −3.3(4.0), −6.3(5.3), −8.8(4.5)) at endpoint −1.1(4.3), −7.4(5.6), −8.2(5.3)). Relevantly, slowdown is associated 0.0001), ketonemia ≤ 0.001), parameters 0.05). Conclusions: Our findings highlight applicability monitor obesity-related precision medicine show efficacy slowing aging.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 19, 2025
The metabolites of the ketogenic diet (KD), specifically ketone bodies (KB), are closely linked to brain health. KD is widely used treat epilepsy. It's also getting more attention for treating neurodegenerative disorders like Alzheimer's and Parkinson's diseases, its effectiveness in these areas well - recognized. This study aims explore research hotspots field health from 2013 2024, providing references directions future research. utilized R software, VOSviewer, CiteSpace analyze 1,162 publications this 2024. A total were included study. From 2021, there was an upward trend number field, followed by a slight decline 2021 2023. United States has highest exhibits most extensive collaboration with other countries, positioning it as leading nation field. journal Nutrients publications, while Epilepsia cited journal. Key subject terms include KD, Brain, Beta-Hydroxybutyrate, KB, Metabolism, Oxidative Stress. primary focuses application such epilepsy, role mechanisms metabolism, effects physiological properties (e.g., KB) antioxidative stress neuroprotection on beneficial health, use garnered widespread recognition globally. provides comprehensive in-depth analysis literature offering valuable insights into investigation.
Language: Английский
Citations
0